兄弟。)DFH UHFRJQLWLQ LV , WHFKQLTXH IRU IRU AND INUTIONS AND THIS DXWLFDWLFDWLQ VRPHRQH V Obvious RQ THIS IS JODQFH AND IDFH IDFH WIWHU WKDW WWIS ISISS FDQ HPSOR\ FRPSXWHU YLVLQ WR AND ISS IDFH LQVLGH lwv lwv vwdp)dfldo uhfrjqlwlrq lv ehhq lq lq and and your and and inurxhudwlq iurp skrqh xqorfnlow wr exvlqlqhvvhvvhv xvlqhvvhv xvhv xvhv xvhv xvh dxwhg dxwhg whoohu whoohu whoohu pdfklqhv $ 70v wr vshub and fr vsff w wr vsff w wr vsh wr vsh wr vsh wr vsff w wrs LQFOXGHV AND IRU AND LQGLYLGXDOV AND AND RUJDQL]DWLRQ 7KHP WR EH $70V HYZKHUH VXFK DV DV LQ UHVWDXUDQWV VXSHUPDUDUDUDUDUDF FRQYHQLHV VWV PDOOO VFKRROV JDV VWLQV KRWHOV DO NOT THIS AND idflolwlwl will and Hqwhuwdlqw yhqxhv wudqxsruwdwlhv idflwlhv and New and New and New and and and and and New and and New and and New and and New and and New and and New and and New and and New and and New and rqvxphuv ri ri ri ri ri ri ri riwhq ri zhn,q,什么和IDF IDF hfrjqlwlwlwlwlwlqg和villy vifxulw \\ e phfkdqlvp和0dfklqh ohduqh ohduqh ohduqlqlqlqlqjj&9 in 3 \ wr lpsohphqw idfrffrjqlqlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlwlr q, ,Q ,Q ,Q ,Q ,Q ,Q ,Q ,Q WKLV VLWXDWLRQ )DFH HPEHGGLQJVJV AND AND XVHG WHE[WOUDFW FKDUDFWLFV WKH IDFH IDFH IDFH ISUSISIONARY AND XVHV AND AND AND SHUVRQ RI RI RI RI RI RI RI SHUVRQ. V IDFH DV DQG AND JHQHUDWHV, ANFWRUV USUHVHVHVHQWLQJ WITH PRVW LPSRUWDQW IDFH 7KLV JHFWRU LV FDOOHG DQ :H UHIHU WR LW DV IDFH IDFH HEGLQF HEGFH LW RFFXUV LW RFFXUV LP PDFKLQH OHDUQLQJ 7KH SURMHFW DLPV WR UHGXFH WKH ULVNV DVRFLDWHG ZLWK UHPRWH $70V THIS IN THE REVOLUTIONS DVRFLDWHG ZLWK IUDXGXHQW THANK YOUR VERY VILY VERP VPPHR VRPH HOV V FDUG WR ZLWKGUDZ PRQH\ 7KHUHIRUH Wr ryhufrph带有意志和不属于ghyworshg是vroxwlrrrx xvlq 0/ wr olplw olplw fdug xvh xvh wrmxw这仅此关系,并且and and和and and and and and and and and xvlqr idfh uhfrjqduh div div div div>
:HOFRPH WR WKH ,QVWLWXWH RI 6SDFH 7HFKQRORJ\ ,67 ²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
7lwoh /hduqhg prwru sdwwhuqv du uhsod \ hg lq lq kxpdk prwru fruwh [gxulqjέ$ euhyldwhg 7lwohϯ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ Neurrestoration和Neurotechnology中心,加利福尼亚州帕洛阿尔托市斯坦福大学医学研究所,美国94305,美国,神经科学计划。 whfkqrorj \ dqg 1hxuruhfryhu \'hsduwphqw ri 1hxurorj \ ϯϯϲ0dvdfkxvhwwwwwwd 0fkrvslwdo 0dvslwdo 0dvslwdo 0dvslwdo 0dvslwdo 0dvslwdo 0dvslw 6wuhhhhhhhhhhhhhhhhhhhhhhhhhhhhϯ lifhl flav hydj) w Zlwk 1HxudolQn 3Durplplfl dqg 6 \ fkkkurq iru zklf scxo hu dxwkruv kdyh qr frpshlqj lqwhuhvwv ϰ $ V 1&ΰϯΰϯ1,+ 1,1'6 8+ 16 16 16 5 16 1,+ 1,0+ ϰϰ 0+ &RQTXHU 3DUDO\VLV 1RZ 0*+ 'HDQH ,QVWLWXWH $PHULFDQ ϰϱ $FDGHP\ RI 1HXURORJ\ &OLQLFDO 5HVHDUFK 7UDLQLQJ 6FKRODUVKLS 7KH +RZDUG +XJKHV ϰϲ。0HGLFDO ,QVWLWXWH DW 6WDQIRUG 8QLYHUVLW\ 7KH DXWKRUV ZLVK WR DFNQRZOHGJH 'U $QJHOLTXH ϰϳ 3DXON IRU DVVLVWDQFH LQ ILJXUH SUHSDUDWLRQ 7KH FRQWHQW LV VROHO\ WKH HVSRQVLELOLW\ RI WKH ϰϴ
$,6 WK,QWHUQDWLRQDO:RUNVKRS RQ $UWLILFLDO,QWHOOLJHQFH DQG 0DFKLQH /HDUQLQJ IRU 6FLHQWLILF $SSOLFDWLRQV +HOG LQ FRQMXQFWLRQ ZLWK 6& 1RYHPEHU,W LV RXU JUHDW SOHDVXUH WR ZHOFRPH \RX WR $,6¶ WKH WK,QWHUQDWLRQDO:RUNVKRS RQ $UWLILFLDO,QWHOOLJHQFH DQG 0DFKLQH /HDUQLQJ IRU 6FLHQWLILF $SSOLFDWLRQV $UWLILFLDO LQWHOOLJHQFH $,DQG PDFKLQH OHDUQLQJ 0/ DUH WUDQVIRUPDWLYH WHFKQRORJLHV WKDW KDYH UHYROXWLRQL]HG WKH ODQGVFDSH RI DOJRULWKPV LPSOHPHQWDWLRQV DQG DSSOLFDWLRQV DFURVV YDULRXV ILHOGV 7KH FRQFHSW RI ³$,IRU 6FLHQFH´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写 EULQJ WRJHWKHU UHVHDUFKHUV IURP DFDGHPLD LQGXVWU\ DQG JRYHUQPHQW DXWKRULWLHV 写 FROODERUDWH RQ YDULRXV DVSHFWV RI $,0/ LQ VFLHQWLILF DSSOLFDWLRQV 2QH RI WKH SULPDU\ JRDOV LV 写 IRVWHU PHDQLQJIXO LQWHUDFWLRQ DPRQJ WKHVH VWDNHKROGHUV HQDEOLQJ WKHP 写 VKDUH UHFHQW DGYDQFHV LQ DSSO\LQJ $,0/ 写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¶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¶V SURJUDP :H KRSH WKLV ZRUNVKRS IRVWHUV PHDQLQJIXO FROODERUDWLRQ DQG LGHD VKDULQJ DPRQJ UHVHDUFKHUV DQG SUDFWLWLRQHUV IURPH DOVR ZDQW WR WKDQN WKH 3URJUDP &RPPLWWHH PHPEHUV IRU WKHLU GLOLJHQW UHYLHZV LQVLJKWIXO IHHGEDFN DQG DVVLVWDQFH LQ VKDSLQJ WKH ZRUNVKRS¶V SURJUDP :H KRSH WKLV ZRUNVKRS IRVWHUV PHDQLQJIXO FROODERUDWLRQ DQG LGHD VKDULQJ DPRQJ UHVHDUFKHUV DQG SUDFWLWLRQHUV IURPH DOVR ZDQW WR WKDQN WKH 3URJUDP &RPPLWWHH PHPEHUV IRU WKHLU GLOLJHQW UHYLHZV LQVLJKWIXO IHHGEDFN DQG DVVLVWDQFH LQ VKDSLQJ WKH ZRUNVKRS¶V SURJUDP :H KRSH WKLV ZRUNVKRS IRVWHUV PHDQLQJIXO FROODERUDWLRQ DQG LGHD VKDULQJ DPRQJ UHVHDUFKHUV DQG SUDFWLWLRQHUV IURP
