l咨询/酬金:Roche/genentech,Abbvie,Amgen,Apobiologix,Astra Zeneca,Acerta,Acerta,Celgene,Kite/Giete/Gilead,Incyte,Incyte,Janssen,Karyopharmarm,Lundbeck,Merck,Merck,Merck,Morphosys,Morphosys,Morphosys,Seagen,Teva,Teva,Teva,Takeda,Takeda,Takemem
contramyl XR是经批准的扩展释放(ER)哌醋甲酯,可用于治疗儿童和青少年(6-17岁),成人(18-65岁)符合DSM-IV或DSM-IV或DSM-V标准ADHD。与ER渗透释放的口服系统(Oros)哌醋甲酯相比,Contramyl XR使用多单位颗粒系统(MUP),因为经过修改的,受控的释放系统已被证明可以叠加相同的双相释放的甲基苯甲酯。多单位颗粒系统是两个最广泛使用的输送系统之一,用于连续和受控的哌醋甲酯,另一个是OROS。其他一些ER的ER口服递送系统包括球形口服药物吸收系统(例如,sodas,例如Ritalinla®),修改后的释放颗粒(例如medikinetMr®),Oros(例如Concerta®,Neucon®,Mefedenil®,UnicornMPH®),亲水基质释放系统(例如radd®)和ER膜涂层片(例如Acerta®)。
AFH: Consulting or advisory roles (Bristol-Myers Squibb, Seattle Genetics, Merck, Genentech, Inc./ F. Hoffmann-La Roche Ltd, AstraZeneca/Medimmune, ADC Therapeutics, Takeda, AstraZeneca/Medimmune, Karyopharm, ADC, Regeneron, Genmab, Tubulis GmbH, Pfizer, Adicet Bio,Caribou Biosciences,Abbvie);旅行,住宿,费用(Bristol-Myers Squibb);研究资金(Bristol-Myers Squibb,Merck,Genentech,Inc./f。Hoffmann-La Roche AG,风筝,Gilead Company,Astrazeneca,Seattle Genetics,Gilead Sciences,ADC); ST:就业(Genentech,Inc。);领导力(F. Hoffmann-La Roche); LHS: Consulting or advisory role (Celgene, AbbVie, Seattle Genetics, TG Therapeutics, Janssen, Amgen, F. Hoffmann-La Roche/Genentech, Inc., Gilead Sciences, Lundbeck, Amgen, Apobiologix, Karyopharm Therapeutics, Kite, a Gilead Company, Merck, Takeda, Teva, TG Therapeutics,阿斯利康(Astrazeneca),Acerta Pharma,Morphosys,Incyte,Debiopharm群,Sandoz-Novartis,Genmab,Verastem); Honoraria(Amgen,Apobiologix,Abbvie,Celgene,Gilead Sciences,Janssen-Ortho,Karyopharm Therapeutics,Lundbeck,Merck,F。Hoffmann-La Roche La Roche Ltd/Genentech Ltd/Genentech Ltd/Genentech,Inc. Debiopharm群,Sandoz-Novartis,Verastem,Genmab);研究资金(F. Hoffmann- La Roche Ltd/Genentech,Inc。,Teva); FJ:咨询或咨询角色(F. Hoffmann-La Roche Ltd); Honoraria(F. Hoffmann-La Roche Ltd,Celgene,Janssen,Abbvie/Genentech,Inc。); GL:咨询或咨询角色(Genentech,Inc./f。Hoffmann-La Roche Ltd, Janssen-Cilag, Bristol-Myers Squibb, Novartis, MorphoSys, AstraZeneca, Gilead Sciences, Genmab/Seattle Genetics, Incyte, ADC Therapeutics, AbbVie, Genase, Immagene, Hexal, Lilly, Sobi, PentixaPharm, Miltenyi Biomedicine, Karyopharm Therapeutics);旅行,住宿,费用(Janssen-Cilag,Genentech,Inc./f。Hoffmann-La Roche Ltd,Abbvie,Gilead Sciences);专家证词(F. Hoffmann-La Roche Ltd); Honoraria(Janssen-Cilag,F。Hoffmann-La Roche Ltd/Genentech,Inc。),Astrazeneca,Bristol-Myers-Myers Squibb,Gilead Sciences,Novartis,Abbvie,Genmab/Genmab/Seattle Genetics,Constellation Genetics,Constellation Pharmaceuticals,adc Therapeuticals,adc Therapeutics,Incyte,Incyte,Sobi),Sobi);研究资金(Janssen-Cilag,F。Hoffmann-La Roche Ltd/Genentech,Inc。,Astrazeneca,Aquinox,Aquinox,Aquinox,Bayer,Gilead Sciences,Morphosys,Morphosys,Verastem,Verastem,Agios); MT:咨询或咨询角色(Takeda,Bristol-Myers Squibb,Incyte,Abbvie,Amgn,F。Hoffmann-La Roche Ltd,Gilead Sciences,Janssen,Morphosys,Morphosys,Novartis);旅行,住宿,费用(Gilead Sciences,Takeda,Bristol-Myers Squibb,F。Hoffmann-La Roche Ltd,Janssen,Abbvie); Honoraria(Janssen,Gilead Sciences,Takeda,Bristol-Myers Squibb,Amgen,Abbvie,F。Hoffmann-La Roche Ltd,Morphosys,Morphosys,Novartis); GS:咨询或咨询角色
作者要感谢参与的患者及其家人、临床医生和 BT5528-100 研究的研究人员。医学写作由 Avalere Health Global Limited 的 Becky Bradley 博士和 Rebecca L. Crepeau 博士提供支持,并由 BicycleTx Ltd. 资助。EF 披露了以下关系:就业 - HCA/Sarah Cannon。咨询或顾问角色 - Astellas;辉瑞。研究资金(机构) - Acerta;ADC;安进;Arcus;Array;Artios;Astellas;Astex;阿斯利康;Basilea;拜耳;百济神州;Bicycle;BioNTech SE;Blueprint;勃林格殷格翰;Calithera;Carrick;Casi;Clovis Oncology;Crescendo;CytomX;第一三共;Deciphera;礼来;Ellipses;Exelixis;F. Hoffman-La Roche;Fore;G1;基因泰克;葛兰素史克; H3生物医学;哈金森医药制药公司;伊格尼塔/罗氏;免疫核心;免疫医学;因塞特;注入生物; IOVANCE;詹森;江苏恒瑞医药;克罗诺斯生物;羽扇豆有限公司;宏观遗传学;梅纳里尼;默克公司;梅雷奥;梅鲁斯;千年;默沙东;内维亚诺;努里克斯;肿瘤学;牛津 Vacmedix;辉瑞;普莱克斯康; PMV制药公司;量子电子学;中继;修复;丝带;罗氏;智慧;希根;施维雅;茎线;合成通;大凤;特萨罗;转折点;武田.专利、特许权使用费、其他知识产权 - 专利号:1716712.3 正在申请中。演讲者费用:CARIS 生命科学。旅行、住宿、费用 - 自行车; CARIS 生命科学;修复;智慧; Seagen。其他关系 - 欧洲癌症研究与治疗组织 (EORTC);美国医院公司 (HCA) 国际。
利益宣言C.J.W.获得:药房的资金支持;持有:Biontech,Inc; G.G.是创始人,顾问,并持有Scorpion Therapeutics中的私人股权,从以下方面获得了资金支持:IBM和Pharmacyclics,是有关专利申请的发明者,该专利申请与:突变,Mustute,Mutsig,msmutect,msmutect,msmutsig,msmutsig,msmutsig,msidetect,msidetect,polysolver,polysolver,tensorqtl; R.G.获得:Abbvie,Janssen,Gilead,Astrazeneca和Roche的资金支持; N.J. receives research funding from: Pharmacyclics, AbbVie, Genentech, AstraZeneca, BMS, Pfizer, Servier, ADC Therapeutics, Cellectis, Precision BioSciences, Adaptive Biotechnologies, Incyte, Aprea Therapeutics, Fate Therapeutics, Mingsight, Takeda, Medisix, Loxo Oncology, Novalgen and serves on Advisory Board /Honoraria:药房,Janssen,Abbvie,Genentech,Astrazeneca,BMS,适应性生物技术,精密生物科学,服务者,贝吉尼,Cellectis,TG Terapeutics,ADC Therapeicts,ADC Therapeutics,Mei Pharma; W.G.W.报告资金来自GSK/Novartis,Abbvie,Genentech,Pharmacyclics LLC,Astrazeneca/Acerta Pharma,Gilead Sciences,Juno Therapeutics,Kite Pharma,Sunesis,Sunesis,Miragen,Miragen,Oncternal Therapeutics,incternal Therapeutics,Inc.,Cyclacel,Loxo Oncology Oncology oncology,colical,Inc. inc. janssen,jansesen,jansen,jansen,jansen,jensen,xencor。B.A.K,C.J.W和G.G. 是专利的发明者:“表征慢性淋巴细胞性白血病的组成,面板和方法”(PCT/US21/45144); S.A.S. 报告了Bristol-Myers Squibb的非财务支持,以及Agenus Inc.,Agios Pharmaceuticals,Breakbio Corp.,Bristol-Myers Myers Squibb和Lumos Pharma中的股权。 N.P. 目前是Bristol Myers Squibb的雇员。 K.J.L. C.J.W. M.D.,J.D.K。B.A.K,C.J.W和G.G.是专利的发明者:“表征慢性淋巴细胞性白血病的组成,面板和方法”(PCT/US21/45144); S.A.S.报告了Bristol-Myers Squibb的非财务支持,以及Agenus Inc.,Agios Pharmaceuticals,Breakbio Corp.,Bristol-Myers Myers Squibb和Lumos Pharma中的股权。N.P. 目前是Bristol Myers Squibb的雇员。 K.J.L. C.J.W. M.D.,J.D.K。N.P.目前是Bristol Myers Squibb的雇员。K.J.L. C.J.W. M.D.,J.D.K。K.J.L.C.J.W. M.D.,J.D.K。C.J.W.M.D.,J.D.K。M.D.,J.D.K。持有标准Biotools Inc.(以前为FlusIdigm Corporation)的权益。和E.M.P是美国公用事业申请号的发明者US-2022– 0298580-A1于2012年10月10日提交,国际申请号WO/2021/041669于9/15/2022提交,“免疫签名可预测Richter转换中对PD-1封锁的反应。”。和B.T.没有相关的COI。C.T. 报告了Beigene,Janssen,Abbvie,Az和Loxo的酬金,以及Beigene,Janssen和Abbvie的研究资金。C.T.报告了Beigene,Janssen,Abbvie,Az和Loxo的酬金,以及Beigene,Janssen和Abbvie的研究资金。
