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现代奴隶制报告-2023- ...
• Annual review of the terms of the Code of Business Conduct with updates communicated to team members • Annual compliance certification for the Code of Business Conduct by salaried team members • Annual review of the terms of the Supplier Code of Conduct • Annual Supplier Code of Conduct compliance certification process with approximately 450 suppliers • Linking our commercial activities with suppliers to our Supplier Code of Conduct • Ongoing values training for salaried team members • Rolling out “The Way We Work” to frontline team members •执行旨在防止强迫劳动和童工的长期政策和流程，包括验证就业年龄，ID验证，劳动时间的加班跟踪和工作场所的尊重，以及强大的健康健康和安全政策和安全政策和程序和程序和程序•促进各种社交报告•促进我们的机构求职者•促进我们的机构求职•我们的机构求职•我们的合格范围•我们的范围•我们的范围•我们的范围求职•我们的范围•我们的范围求职•我们的范围求职•我们的范围•我们的合格范围•我们的机密性范围•我们的范围使我们的范围合格•我们的大部分劳动力
Novel Variant and Known Mutation in 23S rRNA Gene of Mycoplasma pneumoniae, Northern Vietnam, 2023
ycoplasma pneumoniae is a common etiologic agent of community-acquired pneumonia (CAP) among children. Although M. pneumoniae infection often causes a mild and self-limiting dis- ease, pneumonia develops in ≈ 10%–20% of pediatric patients ( 1 ). First-line therapies for M. pneumoniae infection are based on macrolides, a group of anti- microbial drugs widely used in outpatient settings because of their high oral bioavailability. However, overuse and indiscriminate use of macrolides have contributed to the emergence of macrolide-resistant M. pneumoniae (MRMP). Point mutations in the V region of the M. pneumoniae 23S rRNA gene have been associated with macrolide resistance ( 2 ). In recent years, prevalence of MRMP has increased and is very high in Asia (13.6%–100%) ( 2 – 4 ). Dur- ing spring/summer 2023, hundreds of children with CAP were admitted daily to each of the major hospi- tals in Hanoi, Vietnam. M. pneumoniae has emerged as the major pathogen detected in approximately one third of patients with CAP (5). We analyzed the mutations in the 23S rRNA gene of M. pneumoniae isolated from nasopharyngeal samples of pediatric CAP patients during the 2023 outbreak in Vinmec Times City Hospital, Hanoi.
低收入国家和中等收入国家的COVID-19疫苗推出
COVID-19疫苗LMIC推出的关键战略决策正在专门用于采购Covid-19-19疫苗对LMICS的采购（尽管迄今为止采购的剂量仍然不足以覆盖LMIC种群），但在计划和实施集团内推销方面投入了很多资金。Covax最近的报告表明，在国内疫苗推出的费用约为每剂1.5美元，以便提供疫苗以覆盖人口的前20％，而不包括医疗保健劳动力的成本。Of this, COVAX has estimated that approximately $1 per dose would need to come from sources other than COVAX (for example, domestic, bilateral, or multilateral sources) at an estimated total of $1.3 billion.⁸ COVAX already expects to provide more than 20 percent population coverage by the end of 2021, and many LMICs have sourced additional doses through regional and bilateral deals, so the total rollout funding requirement仅在2021年就可能要大得多。尽管从理论上讲，世界银行的120亿美元贷款计划可以用于疫苗交付活动，但尚不清楚各国是否会选择使用这种融资机制。
使用计算机使用Web应用的糖尿病预测...
糖尿病变得越来越普遍，并且普遍存在。目前，大约有3.82亿个人生活在全球疾病中，到2035年，这一数字将翻了一番以上，达到5.92亿。The rise couldbe attributed to suburbanization, the progressive adoption ofpoor lifestyle choices, and the ageing of the populationwithout adequate preparation for prevention and treatment, posing various problems for diabetes care, which seems tohave become a major health problem in the majority ofnations around the world.Diabetes affects approximately 200 million peopleworldwide, with a yearly prevalence of 7%.在更长的时间里，人们患有多种疾病，在某些情况下可能已经避免了，但是由于患者缺乏症状的速度差异，这可能会产生灾难性的影响。最近已经对疾病预测的主题进行了几项研究，以至于一些医生现在采用机器学习模型来预测某些疾病。因此，创建既简单又精确且具有成本效益的Adiabetes分类器至关重要。研究方法提供了一种对与人类相关的应用领域有用的种类，例如临床诊断，这是一种程序，在该程序中，疗程学家必须为了诊断糖尿病而分析大量因素，从而使医生的工作变得困难且时间累。深度学习和数据收集结果已被证明是对各种医疗疾病的自动诊断技术非常有用的[1]。
Sihuan Pharmaceutical Holdings Group Ltd.
•该集团的收入主要来自其业务集中的治疗领域。，神经系统领域的收入约为19.69亿元人民币，占总收入的29.8％，比2022年减少了约13.1％。肿瘤学领域的收入约为15.76亿元人民币，占总收入的23.9％，比2022年增加了约10.2％。自身免疫领域的收入约为14.15亿元人民币，占总收入的21.4％，比2022年增加了约10.5％。其他领域的收入约为16.48亿元人民币，占总收入的24.9％，比2022年增加了约22.3％。
My Pathway Her2篮子研究：Pertuzumab + Trastuzumab ...
截至2020年12月，flatiron Health and Foundation Medicine诊所基因组数据库（CGDB）的患者来自患有HER2扩大实体瘤的患者。The retrospective longitudinal clinical data were derived from electronic health record (EHR) data from approximately 280 US cancer clinics (~800 sites of care), comprising de-identified patient-level structured and unstructured data, curated via technology-enabled abstraction, and were linked to genomic data derived from FMI comprehensive genomic profiling tests in the Flatiron Health-FMI CGDB by取消确定的确定性匹配。1-3的乳房，胃和胃食管癌被此处显示的数据省略，与HER2扩增/过表达肿瘤的患者的MyPathway分析中排除了肿瘤类型。b“其他”包括皮肤/软组织，食管，其他胃肠道来源，内分泌，其他妇科，中枢神经系统，未知主要的癌症（包括模棱两可的诊断），头部和颈部，肝细胞，其他生殖器，其他生殖器和神经内分泌。c百分比总计高至> 100％，因此由于四舍五入。1。ma X等，Medrxiv 2020.03.16.20037143; 2。Birnbaum B等人，Arxiv 2001.09765 [Cs.cy]; 3。Singal G等人，JAMA 2019; 321：1391–9。CGDB，临床基因组数据库； FMI，基金会医学。
My Pathway Her2篮子研究：pertuzumab +曲妥珠单抗治疗
截至2020年12月，flatiron Health and Foundation Medicine诊所基因组数据库（CGDB）的患者来自患有HER2扩大实体瘤的患者。The retrospective longitudinal clinical data were derived from electronic health record (EHR) data from approximately 280 US cancer clinics (~800 sites of care), comprising de-identified patient-level structured and unstructured data, curated via technology-enabled abstraction, and were linked to genomic data derived from FMI comprehensive genomic profiling tests in the Flatiron Health-FMI CGDB by取消确定的确定性匹配。1-3的乳房，胃和胃食管癌被此处显示的数据省略，与HER2扩增/过表达肿瘤的患者的MyPathway分析中排除了肿瘤类型。b“其他”包括皮肤/软组织，食管，其他胃肠道来源，内分泌，其他妇科，中枢神经系统，未知主要的癌症（包括模棱两可的诊断），头部和颈部，肝细胞，其他生殖器，其他生殖器和神经内分泌。c百分比总计高至> 100％，因此由于四舍五入。1。ma X等，Medrxiv 2020.03.16.20037143; 2。Birnbaum B等人，Arxiv 2001.09765 [Cs.cy]; 3。Singal G等人，JAMA 2019; 321：1391–9。CGDB，临床基因组数据库； FMI，基金会医学。
利物浦心脏和胸部医院NHS基金会信托
利物浦心脏和胸部医院（LHCH）为北威尔士默西塞德郡的人们，曼岛以及兰开夏郡和柴郡的部分地区提供医学和外科手术心理服务。该集水区的人口为280万。医院提供了一系列侵入性和非侵入性诊断性心肺设施。有两个专用的心脏MRI扫描仪和心脏CT扫描仪，心脏诊断中的大型心脏成像部门将所有超声心动图模式。有七个用于诊断程序的心脏导管实验室，PCI，结构性心脏病，电生理学和消融以及起搏。We have a hybrid pacing theatre used approximately 40% of the time for cardiac devices (the remaining sessions are for aneurysm surgery/aortic stenting/TAVI) During the last year, over >5000 MRI scans, >1000 pacing procedures, >1700 catheters, >2900 PCI procedures (800 PPCIs) and >1300 EP procedures were performed and more than 400 complex pacing/device程序。该中心是NHS基金会信托基金，在过去的几年中，该基金会的发展已经发生了很大的发展。由于主要资本投资，中心能够提供：
Steiner II染色套件
试剂小瓶以标有载体的条形码提供，以插入仪器的试剂托盘中。Each kit contains sufficient reagent for 40 tests: One 19 mL vial of Steiner II Oxidizer contains 1.0 % zinc chloride, approximately 4% formaldehyde One 15 mL vial of Steiner II Silver A contains 0.25% silver nitrate One 15 mL vial of Steiner II Diffuser contains 50% reagent alcohol One 15 mL vial of Steiner II Enhancer contains 5% gum mastic and absolute ethanol* One 27 mL vial of Steiner II Clean A contains 95% reagent alcohol* One 19 mL vial of Steiner II Reducer contains 0.8% hydroquinone One 19 mL vial of Steiner II Silver B contains 0.20 % silver nitrate One 27 mL vial of Steiner II Clean B contains 95% reagent alcohol** Seven vial inserts with sipping straws Cotton swabs * Steiner II Clean A vial Steiner II增强剂小瓶必须在试剂托盘中彼此相邻。** Steiner II Clean B没有条形码标签，并且不打算将其插入试剂托盘中。
研究用微生物定植的微塑料的冰成核活性
微塑料（MPS）是一种新兴的污染物，具有许多未知的健康和环境后果。MPS进入环境后，它们会暴露于自然风化中，这可以改变其润湿性并增加其裸露的表面积。表面积的增加为微生物提供了底物，进而改变了MPS的表面特征。此外，在沉积之前，可以轻松地将MPS雾化和长距离进行。当MP在大气中，它们不仅与其他污染物相互作用，而且还可以充当冰核颗粒（INP），为云形成和影响降水提供了基础。实际上，最近的一项研究发现云中存在的MP。To evaluate the hypothesis that MPs may act as INPs, polystyrene microplastics varying in size (1 µ m to 100 µ m) and surface roughness were subjected to a freezing droplet assay from 0 ◦ C to approximately -14 ◦ C. A subset of these MPs were then added to the culture of a known bacterial ice nucleator, Pseudomonas syringae , which has been shown to play a role in水周期。这些用丁香假单胞菌培养的MP也暴露于相同的冷冻液滴测定中，并将结果与单独的MPS进行比较。我们的结果表明，MPS上生物膜的大小，粗糙度和存在会影响其作为INP的能力。这些结果对在整个环境中建模MPS及其对云和气候的影响有影响。