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原创研究转铁蛋白修饰的蛋白质-脂质混合纳米颗粒可有效递送顺铂和多西他赛用于靶向肺肿瘤
目的：非小细胞肺癌（NSCLC）治疗面临包括耐药性在内的障碍。设计了一种转铁蛋白功能化的蛋白质-脂质混合纳米颗粒（PLHN），其中同时装载顺铂（CIS）和多西他赛（DTX），用于肺癌治疗。方法：将CIS和DTX装入混合纳米颗粒中，然后用转铁蛋白（Tf）修饰。通过确定释放行为、体外细胞毒性和体内抗癌效率来研究Tf功能化的蛋白质-脂质混合纳米颗粒（Tf-CIS/DTX-PLHN）。结果：Tf-CIS/DTX-PLHN的纳米尺寸为189.5±5.9纳米，表面测试为-16.9±2.1 mV。 Tf-CIS/DTX-PLHN体外和体内抗肿瘤能力明显优于不含Tf的CIS和DTX共载脂质纳米粒（CIS/DTX-LN）、单一载药纳米粒和游离药物。结论：由于Tf的增效作用和药物的协同作用，Tf-CIS/DTX-PLHN可以抑制肺癌肿瘤生长，有助于肺癌的治疗。关键词：肺癌，混合纳米粒，纳米结构脂质纳米粒，蛋白质纳米粒，转铁蛋白
NVIDIA HGX H100数据表
HGX H100系统中使用的NVIDIA H100 GPU具有变压器引擎，具有FP8 Precision，可为大型语言模型（例如GPT-3 175B）提供高达4倍的训练。The combination of fourth-generation NVLink, which offers 900GB/s of GPU-to-GPU interconnect, NVLink Switch System, which accelerates collective communication by every GPU across nodes, PCIe Gen5, and NVIDIA Magnum IO ™ software delivers efficient scalability, from small enterprises to massive, unified GPU clusters.这些基础架构与NVIDIA AI Enterprise Software Suite合作，使NVIDIA HGX H100成为最强大的端到端AI和HPC数据中心平台。
世界是量子碎片的堆吗？
抽象的片段主义最初是作为新的时间理论引入的。它得到了进一步的修订和讨论，并提出了原始见解的不同发展。In a celebrated paper, Jonathan Simon contends that frag- mentalism delivers a new realist account of the quantum state—which he calls conservative realism —according to which: (i) the quantum state is a complete description of a physical system, (ii) the quantum (superposition) state is grounded in its terms, and (iii) the superposition terms are themselves grounded in local goings-on about the system in question.我们将争辩说，碎片主义至少沿西蒙提出的线条并没有提供对量子状态的新的，令人满意的现实描述。这就提出了一个问题，即是否还有其他一些可行的量子碎片主义形式。
Bausch Health Saters on Selections ofXifaxan®（...
We look forward to engaging in open and transparent conversations with CMS, where we will share information on the value that XIFAXAN® delivers for the healthcare system in addition to sharing recommendations from The American Association for the Study of Liver Diseases (AASLD) and the European Association for the Study of the Liver (EASL) who gave XIFAXAN® the highest possible recommendation (Grade I, A,1) via their practice guidelines.我们将继续受到对患者的承诺，倡导支持患者获得关键药物的医疗保健环境，并鼓励未来的创新。关于xifaxan指示xifaxan®（利法西明蛋白）550毫克片剂用于降低成人成人明显的肝性脑病（HE）复发的风险，并治疗成人腹泻（IBS-D）的肠易激综合症。重要的安全信息
红色的阳光电池和债券库-Redstaregg.com
红色移动热电池的最高用途是节省浪费的夜间能源，并从可再生能源（RE）和核电站以2.5美分至3美分的价格购买，夜间以12美分/千瓦时的价格购买。As first mobile thermal battery that carries enough to run small city or refinery of 360 MWh on truck, rail or ship, it charges at night at wind, hydro, geothermal, biomass or industrial waste heat and delivers in the day to create the first mobile “ Energy Arbitrage” system that is insured by Lloyd's Syndicate, and therefore able to be monitized and can be turned into an utility bond and insurance- backed security that is A- rated并且可以在二级市场的几分钟或几个小时内出售。此外，通过将红色的阳光添加到您的能源，运输或炼油厂项目中，通过这种保险支持的包装和/或债券融资对信贷客户的财务可行；独立的电力工具，最低售价为0.12美元/千瓦时，及其初步的DOE服务合同。因此，15年至25年的电力公司合同
ECE Senior Design
Abstract The need for accessible, cost-effective, and immediate communication tools for the deaf and hard-of-hearing community is a critical issue. Current available technologies are costly, complex, and unable to be seamlessly integrated into daily life. Our solution is to introduce a revolutionary wearable device: glasses that provide real-time speech-to-text transcription. By integrating advanced technology into a discrete, everyday accessory, we will be reducing communication barriers faced by individuals who are deaf or hard of hearing. The final deliverable is a proof of concept equipped with an OLED display that will display transcribed text into the user's field of vision, an ESP32-C3 for wireless communication, and two microphones for audio capture. Additionally, we will develop an iOS-compatible mobile application that enables the user to reference past conversations and customize the displayed text based on their preferences. Our technical approach leverages continuously improvable open-source speech recognition software, a practical optical design, and an efficient microcontroller. Our end product delivers a new way for deaf and hard-of-hearing individuals to communicate, cultivating a more inclusive world where every voice and word can be heard and understood.
用于住宅和
India ---------------------------------------------------------------------***--------------------------------------------------------------------- Abstract - An Uninterruptible Power Supply (UPS) is an essential technology that delivers instantaneous backup power to electronic devices during a power failure.作为对行业，住宅和企业中电子设备的依赖，保证不间断的电源已成为优先事项。本文详细介绍了UPS系统的设计和构建，该系统将AC与DC和DC集成到AC转换，并使用电池来确保链接设备的操作连续性。该系统由一个1通道继电器模块支配，该模块在电源中断时巧妙地在主电源和辅助电池之间进行交替。研究集中于开发可靠的可靠系统，该系统可以避免数据丢失和设备危害。该方法涵盖了在许多负载情况下对UPS的全面实验框架，模拟和经验评估。结果表明效率升高和快速切换时间，确保了连锁负载的不间断电源。该系统是确保在中断期间连续电源的可靠选择，并在医院，数据中心和工业控制系统等基本设置中进行了可能的应用。
NELC Children in Care and Care Leavers sufficiency strategy
good outcomes, we will always reflect whether our focus should be on investing in additional support with birth families. • The Council's own foster carers and residential settings provide the majority of the required placement capacity within the local area, with the necessary complimentary provision commissioned in a planned and coordinated way from the private and third sectors. Collectively this will ensure that the Council has access to a variety of placement options that is able to meet the changing needs of children in care and care leavers during the lifetime of this strategy. • The Council has an adaptable post 16 accommodation and support offer for older children- in-care and care leavers, enabling skills to be enhanced, with local networks and connections being strengthened, removing barriers in accessing and sustaining accommodation, as well as accessing employment and training opportunities that will enable independent living to be achieved. • The Council develops and delivers a flexible accommodation offer for Care Leavers to access post 18 years old, in addition to ongoing support enable young people to access a variety of housing and support options within their community.
Qualcomm®应用程序处理器选择器指南
•Spectra 480图像信号处理器旨在提供高级相机体验，可以通过高性能捕获200兆像素的照片，8k视频录制和4K HDR视频捕获•Adreno 650视觉处理子系统的高质量捕获，可用于使用较大的Imbersive Experiess（GPU）（GPU）（GPU）（GPU）（GPU）（GPU） 698 DSP with HVX, Hexagon Tensor Accelerator and Hexagon Scalar Accelerator to support sophisticated, on- device AI processing, and delivers mobile- optimized computer vision (CV) experiences for a wide array of use cases • Kryo 585 CPU: Manufactured in 7 nm process node, optimized across four high- performance Kryo Gold cores and four low- power Kryo Silver cores • Qualcomm® Secure处理单元提供了卓越的安全性，旨在帮助保护您的面部数据，虹膜扫描和其他生物识别数据。它支持信任的硬件根，Qualcomm Tee，Secure Boot和Camera Security•随着产品寿命计划的预期，预计到2035年9月的长期支持
