系统数字校园,电子设施:利用生态系统的开放系统探索,第10号。•Elee Messaoudi,AndréTindanoet Masatoshi funabashi«Actes du 4e论坛非洲SUR LA
Course ID Course Title Credits Pre-/Co-requisites MATH 101 Calculus I 3 MATH 100 CSC 101 Introduction to Computing for engineers 3 IT 100 CHEM 101 General Chemistry I 3 CHEM 101L General Chemistry Lab 1 CHEM 101 PHYS 101 General Physics I 3 PHYS 102 General Physics II 3 PHYS 101 PHYS 103L General Physics Lab 1 PHYS 102 (co) CIVE 205 Engineering Drawing 1 CSC 101 ELEE 230 Programming for Engineers 3 CSC 101数学102微积分II 3数学101微积分和分析几何iii 3数学3数学102数学202微分方程3数学102数学215线性代数和数值技术3数学202 Stat 230 STAT 230概率和统计学
摘要:作为中药(TCM)的代表性活跃成分和临床批准的抗癌药,Elemene(Elee)在抗肿瘤领域表现出令人兴奋的潜力;但是,对于术后癌症复发和转移等特定疾病,仍需要探索适当的药物制剂。在此,我们报告了一个带有受控药物释放动力学的ELE水凝胶,该动力学可以使Ele长时间在局部病变部位保持有效浓度,以增强ELE的生物利用度。具体化,多巴胺偶联的透明质酸合成并用来制备ELE纳米果汁包裹的水凝胶。在术后乳腺癌复发和转移的模型中,Ele水凝胶显示出96%的复发率。相比之下,游离的ELE纳米果仅显示复发率为65.5%。Importantly, the ELE hydrogel markedly stimulates a potent antitumor immune response in the microenvironment of cancer lesions, increasing antitumor immune cells such as CD8 + T cells, CD4 + T cells, and M1-type macrophages, as well as elevating antitumor cytokines including TNF- α , IFN- γ , and IL-6.总体而言,这项研究不仅可以发展TCM领域,而且还强调了受控释放水凝胶在改善抗肿瘤治疗方面的变革性影响。■简介