此外,Logicalis拉丁美洲获得了许多合作奖项。Those highlighting its strategic focus include the following awards: • Cisco – Security Partner of the Year, LATAM • Cisco – Collaboration Partner of the Year, LATAM • Cisco – Iot/Industry Partner of the Year, LATAM • Cisco – Service Provider Segment Partner of the Year, LATAM • Cisco – Security Partner of the Year, Brazil • Cisco – Customer Experience Partner of the Year, Brazil • Cisco – Enterprise Partner of the一年,巴西•思科 - 年度服务提供商合作伙伴,巴西•思科 - 巴西年度企业网络合作伙伴,巴西•思科 - 年度商业网络合作伙伴,MCR(Multi Country地区)•Cisco - Cisco - 哥伦比亚年度合作伙伴,MCR(Multi Country Region)
- Thanking the individual for having their vaccine last year (if applicable) - Highlighting that most ‘people like them' get the vaccine - An outline of the number of flu cases in the staff members ward/department during the last flu season - A brief description of any outbreaks (and the impact of them) in the department/hospital in previous seasons - A message from a board member, or senior leader in the organisation, or from someone they trust, respect, or ‘someone like them' asking the member of staff接种疫苗。例如,您向护理总监询问护士,医生的医疗总监等。模板邀请函可以在流感(流感)上找到 - 提供服务和流感的卫生专业人员的信息(仅NHS威尔士工作人员)。
Focusing on deepening our understanding of the molecular complexities that govern the interaction between tumors and immune cells, we invite contributions investigating the role of molecular pathways in tumor immune evasion, characterizing the immune tumor microenvironment, identifying new biomarkers, and highlighting innovative molecular- based immunotherapeutic approaches, such as immune checkpoint inhibitors, CAR-T cell therapy, and cancer 疫苗。本期特刊旨在更多地建立有效的癌症免疫疗法。- 癌症免疫疗法 - 肿瘤免疫微环境 - 肿瘤免疫逃避 - 收养细胞疗法 - 免疫检查点抑制剂 - 基于新抗原的疫苗 - 化学免疫性 - 原发性免疫性 - 适应性免疫性 - 适应性免疫性 - 肿瘤肿瘤 - 肿瘤 - 肿瘤 - 肿瘤 - 含量 - 含量 - 免疫性crosstalk
▶ CeBiTec member Norbert Sewald receives the Jörg Schwarzbich Inventor Award ▶ New funding of Master and PhD student mobility for cooperation between CeBiTec and the International Center for Biotechnology of Osaka University ▶ Information event presenting the current iGEM activities at Bielefeld University ▶ Computational Biology successful in DFG-funded research groups ▶ CeBiTec research group GRIM and the Graduate School DILS analysed microbiome adaptations in a full-scale biogas plant ▶ Kick-off meeting of the EU project iCULTURE ▶ Celebration highlighting the 10-year anniversary of CeBiTec Students Academy ▶ CeBiTec researcher Dr. Nadja A. Henke was awarded a fellowship from Carl- Zeiss-Stiftung ▶ 10 th CeBiTec Students academy in the summer holidays ▶ Project week ‘Medical research trip through the body' in school holidays
图2。MAPBI 3谷物生长。 (a)MAPBI 3成核过程来自半径A的基板表面上的前体,大于临界半径。 晶粒在底物表面生长,生长在损伤后终止。 (b),(c)和(d)MAPBI 3膜在100 O C,130 O C和165 O C退火时的光学显微镜图像(B,C,C,D = 90 µm)。 The dendritic morphology turns spherulitic upon increasing the annealing temperatures, (e) Optical microscope image of MAPbI 3 (scale = 40 μm) crystals spin- coated from 3 M DMSO-based precursors and annealed at 165 o C, (f) SEM Images highlighting the surface morphology of MAPbI 3 crystal film spin-coated over glass from 2M precursor (scale = 100 μm), (g)通过SEM(比例=2μm),(H)Mapbi 3膜的横截面SEM在膜中的三重连接晶界中的变焦,该膜胶片在玻璃上旋转(比例= 1 µm)。MAPBI 3谷物生长。(a)MAPBI 3成核过程来自半径A的基板表面上的前体,大于临界半径。晶粒在底物表面生长,生长在损伤后终止。(b),(c)和(d)MAPBI 3膜在100 O C,130 O C和165 O C退火时的光学显微镜图像(B,C,C,D = 90 µm)。The dendritic morphology turns spherulitic upon increasing the annealing temperatures, (e) Optical microscope image of MAPbI 3 (scale = 40 μm) crystals spin- coated from 3 M DMSO-based precursors and annealed at 165 o C, (f) SEM Images highlighting the surface morphology of MAPbI 3 crystal film spin-coated over glass from 2M precursor (scale = 100 μm), (g)通过SEM(比例=2μm),(H)Mapbi 3膜的横截面SEM在膜中的三重连接晶界中的变焦,该膜胶片在玻璃上旋转(比例= 1 µm)。
图2。Fabricius的Bursa的结构。A: Schematic drawing of the bursa of Fabricius, highlighting the bursal folds, filled with lymphoid follicles and its main cellular components: M- medulla, C- cortex, FAE – follicle associated epithelium, FAE-SC- follicle associated epithelium supporting cell, IFE – interfollicular epithelium, MRC- mesenchymal reticular cell, ERC-上皮网状细胞,Bsdc-分泌树突状细胞,Mφ-巨噬细胞,ly淋巴细胞,cmafc- cmafc- cmafc- cortico-Muspullary拱形形成细胞,bl-基底层:Bl-基底层:BURSAL FOLLSAL FOLLSAL FOLLSAL FOLLSAL FILLECTIC细胞种群:B-裂解症(B-裂解)(b- lymphocyty thempphopphocyty(b- lymphocphocy)(c) Bursal分泌的树突状细胞(D),巨噬细胞(E)。(Nagy等,2022,禽淋巴系统的结构。在鸟类免疫学中,编辑。Kaspers B,Schat K,GöbelT,Vervelde L,学术出版社)
帕金森氏病(PD)的主要病理特征是第二个最常见的神经退行性疾病和最常见的运动障碍,是中脑的一部分Nigra中多巴胺能神经元的主要变性。尽管进行了数十年的研究,但该疾病起源的分子机制仍然未知。最初将这种疾病视为纯神经元疾病,但单细胞转录组学的结果表明,少突胶质细胞可能在帕金森氏症的早期阶段起重要作用。尽管这些发现具有很高的相关性,特别是寻求有效的疾病改良疗法,但Oli-Godendrocytes在帕金森氏病中的实际功能作用仍然高度投机,并且需要一致的科学努力才能更好地进行研究。This Unsolved Mystery discusses the limited under- standing of oligodendrocytes in PD, highlighting unresolved questions regarding functional changes in oligodendroglia, the role of myelin in nigral dopaminergic neurons, the impact of the toxic environment, and the aggregation of alpha-synuclein within oligodendrocytes.
摘要:零工经济以其灵活的工作安排和独立承包商为特征,目睹了近年来的快速增长。但是,它面临着与工人福利,收入安全和工作分类有关的可持续性挑战。本文探讨了人工智能(AI)在零工经济中的新兴作用及其对这些可持续性问题的潜在影响。Through an analytical lens, it examines the current applications of AI in the gig economy across various platforms and tasks, highlighting both efficiencies and potential biases.The anticipated effects of AI on gig workers including job displacement, skill requirements, and potential for wage changes.The implications of AI for the sustainability of the gig economy, analyzing how it might exacerbate existing challenges or pave the way for improvements in worker protections and platform政府。潜力政策的考虑和建议,以确保根据人工智能整合,确保更可持续和公平的零工经济。本文强调需要对AI在零工经济中的潜力有细微的理解,主张采取积极的措施来解决潜在的破坏,并利用其能力为灵活的员工创造更可持续和有益的未来。
Organ-on-Chips (OoCs) have emerged as a human-specific experimental platform for preclinical research and therapeutics testing that will reduce the cost of pre-clinical drug development, provide better physiological relevance and replace animal testing.Yet, the lack of standardization and cost-effective fabrication technologies can hamper wide-spread adoption of OoCs.In this work we validate the use of flat panel display (FPD) tech nology as an enabling and cost-effective technology platform for biomedical applications by demonstrating facile integration of key OoC modules like microfluidics and micro electrode arrays (MEAs) in the standardized 96-well plate format.Individual and integrated modules were tested for their biological applicability in OoCs.For microelectrode arrays we demonstrate 90 – 95% confluency, 3 days after cell seeding and > 70% of the initial mitochondrial cell activity for microfluidic devices.Thus highlighting the biocompatibility of these modules fabricated using FPD technology.Furthermore, we provide two examples of monolithically integrated micro fluidics and microelectronics, i.e.integrated electronic valves and integrated MEAs, that showcase the strength of FPD technology applied to biomedical device fabrication.Finally, the merits and opportunities provided by FPD technology are discussed through examples of advanced structures and functionalities that are unique to this enabling platform.
沿海底栖生态系统可能受到包括水产养殖在内的许多人类活动的影响,水产养殖继续迅速扩展。的确,如今,全世界的水产养殖为人类消费提供了更多的生物量,而不是野生渔业。这一快速发展引发了有关实践与周围环境的互动的疑问。为了设计可持续生态系统开发和海洋空间规划的策略,需要更好地了解沿海生态系统功能,以便可以开发量化包括水产养殖在内的人类活动影响的工具。为了实现这一目标,提出的一些可能的方向是综合研究,导致新概念,基于这些概念的建模以及在全球范围内的各种生态系统的比较。This review draws on existing literature to (i) briefly summarize the major ecological interactions between off ‐ bottom shellfish aquaculture and the environment, (ii) introduce research on the influence of benthic diversity on ecosystem functioning (BEF relationships) and (iii) propose a holistic approach to conduct aquaculture–environment studies using a BEF approach, highlighting the need for integrated studies that could offer insights and perspectives to guide未来的研究工作并改善了水产养殖的环境管理。