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MIT 开放存取文章基于模拟的比较...
摘要：闭环麻醉输送 (CLAD) 系统可帮助麻醉师在较长时间内有效达到并维持所需的麻醉深度。典型的 CLAD 系统将使用根据生理信号计算出的麻醉标记物作为实时反馈，以调整麻醉剂量，以达到标记物的所需设定点。由于 CLAD 的控制策略在最近文献中报道的系统中各不相同，因此对常见控制策略进行比较分析会很有用。对于基于完善的房室药代动力学和 S 型 Emax 药效学模型的非线性植物模型，我们用数字方式分析了三种输出反馈线性控制策略的设定点跟踪性能：比例积分微分 (PID) 控制、线性二次高斯 (LQG) 控制和具有积分作用的 LQG (ILQG)。具体来说，我们针对患者无法获得设备模型参数、控制器基于标称模型设计且控制器增益在整个疗程中保持不变的情况对多个 CLAD 疗程进行了数值模拟。基于此处执行的数值分析，并根据我们选择的模型和控制器，我们推断 PID 控制在准确度和偏差方面优于 ILQG，而 ILQG 又优于 LQG。在噪声观测的情况下，可以调整 ILQG 以提供更平稳的输注速率，同时实现与 PID 相当的稳态响应。此处报告的数值分析框架和结果可以帮助 CLAD 开发人员选择控制策略。本文也可作为 CLAD 控制理论教学的教程论文。
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