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![arXiv:2111.01457v4 [cs.SD] 2022 年 10 月 31 日](/simg/c\cb1162b508e7d25d9394ae5d0bc21f4c32769d20.webp)
arXiv:2111.01457v4 [cs.SD] 2022 年 10 月 31 日
图 6 示例性注意力矩阵，可视化三位参与者在收敛时的注意力得分（来自随机选择的训练样本）（值越亮表示注意力得分越高）。解码器中的时间步长在 y 轴上表示，编码器的时间步长在 x 轴上表示。对角线结构表明注意力得分在时间域上是很好地对齐的，例如输出中的后续步骤关注输入中的后续步骤。该图还表明，填充输入 sEEG 序列（语音规划和理解）可能是不必要的，因为没有太多注意力放在第一个和最后一个输入步骤上。
使用编码器-解码器框架从颅内深度电极合成语音
图 6 示例性注意力矩阵，可视化三位参与者在收敛时的注意力得分（来自随机选择的训练样本）（值越亮表示注意力得分越高）。解码器中的时间步长在 y 轴上表示，编码器的时间步长在 x 轴上表示。对角线结构表明注意力得分在时间域上是很好地对齐的，例如输出中的后续步骤关注输入中的后续步骤。该图还表明，填充输入 sEEG 序列（语音规划和理解）可能是不必要的，因为没有太多注意力放在第一个和最后一个输入步骤上。
胆道癌的免疫检查点抑制剂治疗（...
5.0 months and mOS 8.1 months in gemcitabine alone arm) (9). There is no established second line treatment for advanced BTC, but a recent randomized phase III trial (ABC-06) showed a mOS for 5-fluorouracil and oxaliplatin (FOLFOX) of 6.2 months in patients with disease progression after gemcitabine plus cisplatin (10). These outcomes will form the basis of comparison to the trials described in this review. With limited treatment options and dismal overall prognosis, new therapies and approaches are an urgent unmet need in BTC (11). Clinical trials using targeted agents have historically shown only modest responses in BTC patients, though there has been recent success in treating cholangiocarcinomas with isocitrate dehydrogenase-1 (IDH1) and FGFR genetic alterations with novel targeted agents (12-15). Even in these settings, responses have variable durability and more effective, durable therapies are needed. Immunotherapy has had tremendous success in treating patients with cancers such as melanoma and non-small cell lung cancer, dramatically altering the natural history of these diseases. In BTC, immunotherapy strategies have included autologous cell transfer, vaccinations and immunomodulatory approaches with immune checkpoint inhibitors (ICIs), the latter of which is the largest area of ongoing research. In this review, we describe the rationale for ICI therapy by summarizing the clinically relevant tumor immunology in BTC including the innate and adaptive immune response and immune checkpoint molecule expression in BTC. Subsequently we discuss completed and ongoing clinical trials involving ICI in BTC.
令牌游戏和历史确定性的定量 -
摘要。如果仅考虑到目前为止读取单词的前缀，可以解决其非确定性，那么不确定的自动机是历史性确定的。由于其良好的组成属性，历史确定性的自动机对解决游戏和综合问题很有用。确定给定的非确定性自动机是历史性的 - 确定性（HDNESS问题）通常是一项艰巨的任务，这可能涉及指数过程，甚至是不可确定的，例如，例如在下降自动机的情况下。令牌游戏为Béuchi和CobéuchiAutomata的HDNess问题提供了PTIME解决方案，并且猜想的是2 -Token Games是所有ω-调节自动机的HDNESS。我们将令牌游戏扩展到定量设置，并分析其潜力，以帮助确定定量自动机的HD度。尤其是，我们表明，有限单词的所有定量（和布尔）自动机的HD特征，以及无限单词的折扣（dsum），Inf和可触及性自动机，以及2-图表的2-标记游戏，liminf和liminf and Liminf automata and sup automatama and sup sup sup sup of sup sup of supiente and inspopatienta tocken of insumatiate and sup sup sup sup sup sup sup sup of supienta n in insubiente and inspimapta。Using these characterisations, we provide solutions to the HDness problem of Safety , Reachability , Inf and Sup automata on finite and infinite words in PTime , of DSum automata on finite and infinite words in NP ∩ co-NP , of LimSup automata in quasipolynomial time, and of LimInf automata in exponential time, where the latter two are only polynomial for automata with a对数的重量数量。
