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日本航空航天工业
For a certain period after the end of the war, Japan was forbidden from any activities related to the development and production of aircraft, and our aerospace industry thus fell behind those of the US and Europe. Starting with the licensed production of defense aircraft, national development and production systems have grown. The development and manufacture of defense aircraft forms the foundation of the Japanese aerospace industry. In recent years the F-2 fighter (a joint Japan-US project), the OH-1 observation helicopter, the T-4 and T-7 trainer, and the US-2 search & rescue flying boat have been successfully developed and manufactured. The P-1 Fixed- wing Maritime Patrol Aircraft has been in operation since 2013, and the C-2 Transport Aircraft has begun its delivery to the base in March 2017. Japanese manufacturers are participating in the manufacture of the F-35A fighter jet, helping to further strengthen the foundation of the aerospace industry. Delivery of the F-35A has begun in 2018. Moreover, In 2020, the next fighter(F-2 successor) business had been launched under the leadership of Japan, and on December 14,2023, the Japan, the United Kingdom, and Italy held a meeting of defense ministers to establish an efficient collaboration system in the Global Combat Air Programme (GCAP), which is being jointly developed under the scheme called “GCAP International Government Organisation(GIGO)” and Founding Treaty was signed. In a joint statement, the minister of the three countries signed the “Convention on the Establishment of GCAP Government Agencies” and stated that GIGO would lay the foundation for strengthening the defense industrial base of each country and deploy the next generation of fighter aircrafts by 2035. And in 2021, development of the UH-2 Multipurpose Helicopter, successor to the UH-1J, has
Fixed Point of Interpolative Contraction on Metric Space Endowed with Graph
However, [ 8 ] observed that the fixed point obtained in the above Theorem 1.2 is not necessarily unique. Hence, a robust version of the results in [ 7 ] is provided therein. For some extensions of the idea of interpolative contractions in fixed point theory, we refer to [ 9 , 10 ] and the references therein. Following Petruşel and Rus [ 11 ], a self-mapping T of a metric space ( X, d ) is said to be a Picard operator (abbr., PO ) if T has a unique fixed point x ∗ and lim n →∞ T n x = x ∗ for all x ∈ X and T is said to be a weakly Picard operator (abbr. WPO ) if the sequence { T n x } n ∈ N converges, for all x ∈ X and the limit (which may depend on x ) is a fixed point of T . Jachymski [ 12 ] introduced the notion of contraction in metric space endowed with a graph G . Accordingly, let ( X, d ) be a metric space and let ∆ denote the diagonal of the Cartesian product X × X . Consider a directed graph G such that the set V ( G ) of its vertices coincides with X , and the set E ( G ) of its edges contains all loops, i.e., E ( G ) ⊇ ∆ . It is assumed that G has no parallel edges, so G can be identified with the pair ( V ( G ) , E ( G )) . Moreover, G may be treated as a weighted graph (see [ [ 13 ], p. 376]) by assigning to each edge the distance between its vertices. Denote by G − 1 , the conversion of a graph G , i.e., the graph obtained from G by reversing the direction of edges. Therefore,
warburg效应是与年龄相关黄斑变性的同型半胱氨酸诱导特征的新型机制
摘要：与年龄相关的黄斑变性（AMD）是失明的主要原因。最近的研究报告说，乳酸/丙酮酸含量高的AMD患者的糖酵解受损。在几项临床研究中观察到升高的同型半胱氨酸（HCY）（HCY）（HHCY），报告HHCY和AMD之间存在关联。我们确定了HHCY对小鼠屏障功能，视网膜色素上皮（RPE）结构（RPE）结构（RPE）结构（CNV）的影响。我们假设HHCY通过在线粒体中诱导代谢开关来促进AMD，其中细胞主要通过高糖酵解速率或“ Warburg”效应产生能量。增加的糖酵解导致乳酸，细胞酸度的产生，血管生成的激活，RPE屏障功能障碍和CNV增加。通过海马分析，免疫荧光和蛋白质印迹实验评估了HHCY下细胞能量产生的评估。海马分析评估了细胞外酸性速率（ECAR）作为糖酵解的指示。hhcy在体内显着增加。Moreover, HHcy up-regulated glycolytic enzyme (Glucose transporter-1 (GlUT-1), lactate dehydroge- nase (LDH), and hexokinase 1 (HK1)) in Hcy-treated ARPE-19 and primary RPE cells isolated from cbs +/+ , cbs +/ − , and cbs − / − mice retinas.因此，靶向糖酵解或NMDAR可能是AMD的新型治疗靶标。抑制GLUT-1或N-甲基-D-天冬氨酸受体（NMDAR）降低了HCY处理的RPE中的糖酵解，并改善了注射HCY的小鼠眼睛的白蛋白泄漏和CNV诱导。当前的研究表明，HHCY导致RPE细胞的代谢转换从线粒体呼吸到AMD期间的糖酵解并确认NMDAR在此过程中的参与。
ajtr0145181.pdf
摘要：目的：抑制前蛋白转化酶枯草蛋白/Kexin型9（PCSK9）是否促进了他汀类药物治疗个体中冠状动脉粥样硬化斑块的回归仍然不清楚。这项研究检查了与他汀类药物疗法相比，PCSK9抑制剂与他汀类药物疗法相比是否可以增加动脉粥样硬化斑块的消退。方法：PubMed，PubMed，对照试验的Cochrane Central登记册（中央），DA TABase临床试验和科学网络进行了搜索，以报告使用毒素患者使用血管内超声检查（IVUS）或光学相干性同学（ICT）的PCSK9抑制剂的冠状动脉粥样硬化斑块。随机效应/固定效应模型的加权平均差异（WMD）用于池数据，以满足我们从纳入的研究获得的纳入标准。Results: When compared with statin therapy alone, pooled studies revealed that PCSK9 inhibitors combined with statin therapy significantly decreased percent atheroma vol ume (PAV) (WMD: -1.06%, 95% confidence interval [CI]: -1.39 to -0.73; P<0.001) and total atheroma volume (TAV) (WMD: -6.38 mm 3 , 95% CI：-10.12至-2.64;Moreover, the fibrous cap thickness (FCT) of the coronary atherosclerotic plaque increases to 21.31 um (WMD: 21.31, 95% CI: 7.08 to 35.53, P<0.001), and the maximum lipid arc decreases 10.9° (WMD: -10.9, 95% CI: -15.24 to -5.34, p <0.001）。结论：在我们的系统综述和荟萃分析中，发现与他汀类药物疗法结合使用的PCSK9抑制剂比单独使用他汀类药物治疗更有效，仅通过降低PAV，TAV和增加FCT，最大脂质弧来减少冠状动脉斑块的进展。
在泽西岛与金融犯罪作斗争
问题是，1999年的法律和2008年的法规是否允许在泽西岛不在泽西岛内部的财产上签发塞萨斯司法司法，在这种情况下，有权行使所有权或控制权的人受到泽西州的管辖权（例如，基于泽西人的受托人）的情况。信托基金的受益人断言，泽西法院根据1999年的法律没有管辖权（由2008年的法规修改）授予公寓的Saisies司法司法部级，因为（i）公寓（信托财产）位于新加坡和（ii）公寓是通过在英国英属弗吉尼（BVI）（BVI（BVI）中持有的公寓。枢密院维持了皇家法院和泽西上诉法院的裁决。枢密院确定，需要对立法进行更广泛的解释，即“允许球衣提供更有效的合作和资产恢复”。Moreover, there were ‘particular reasons why it is appropriate for Jersey to provide such assistance' (para [72]), including that Jersey is a jurisdiction with a ‘very substantial trust industry' which commonly saw structures similar to the one in the instant matter (ie a discretionary Jersey law trust, with a BVI-incorporated asset holding company holding underlying assets situated abroad).需要解释的立法，以允许法院发出临时命令，例如Saisies司法司法司法命令，以确保由罪犯或涉嫌犯罪罪所拥有或控制的泽西岛持有的资产受到限制，以解决与没收有关的基本问题的解决。因此，皇家法院被授权授予位于泽西岛以外的可实现财产附属的Saisie司法，前提是对事实上对该财产的所有权或控制权的人在泽西岛的领土管辖范围内。这样的解释将“毫无疑问，为保护泽西岛在金融事务中的声誉提供了重大帮助'（第73章]）。
Nirmatrelvir/Ritonavir是否会独立于反弹？
摘要：在接受Nirmatrelvir/Ritonavir治疗的人（NM/R）治疗的人中，已经报道了冠状病毒19（COVID-19）症状和SARS-COV-2病毒负荷复发的复发。然而，关于这种现象的病因几乎没有理解。我们的目的是研究宿主的免疫反应与病毒反弹之间的关系。我们描述了三例在用Nirmatrelvir/Ritonavir（A组）治疗后发生的Covid-19反弹病例。此外，我们比较了反弹病例的尖峰特异性抗体反应和血浆细胞因子/趋化因子/趋化因子模式与（i）对照患者的nirmatrelvir/ritonavir治疗的患者，这些患者尚未显示回弹（B组）和（ii）未用任何抗SARSARS-SARS-COV-COV-2组治疗的受试者（II）。抗尖峰抗体和血浆细胞因子/趋化因子在A组和B中相似。然而，我们观察到没有抗病毒治疗的患者的抗BA。2尖峰IgG反应（C组）[几何平均滴度210,807、5.1- 5.1-和8.2倍，与A组（P = 0.039）和B组B（P = 0.032）相比（P = 0.032）]。Moreover, the patients receiving antiviral treatment (groups A-B) showed higher circulating levels of platelet- derived growth factor subunit B (PDGF-BB) and vascular endothelial growth Factors (VEGF) and lower levels of interleukin-9 (IL-9), interleukine-1 receptor antagonist (IL-1 RA), and regulated upon activation normal T cell expressed and presumably secreted chemokine （RANTES）与C组相比，总之，我们观察到抗尖峰IgG水平较低，而在Nirmatrelvir/Ritonavir治疗的患者中，与未接受抗SARS-COV-2药物治疗的患者相比。这表明，通过减少病毒载量和抗原表现，早期抗病毒治疗可以减轻针对SARS-COV-2的免疫反应。应在较大的人群中进一步研究这种观察的临床相关性。
在护理点上对经颅电刺激的人体优化：计算角度
摘要：大脑对经颅电刺激（TES）的响应能力的个体差异越来越多地证明了TE的影响的巨大差异。已开发出解剖学上详细的计算大脑模型来解决这种可变性。但是，静态大脑模型在解释大脑的动态状态时并不是“现实的”。因此，基于TES神经血管效应的系统分析，在此观点文章中提出了在护理点上的人类在循环中的优化。首先，使用生理详细的神经血管模型进行了模态分析，该模型在0 Hz至0.05 Hz范围内，通过平滑肌细胞在0 Hz至0.05 Hz范围内进行途径，该模式通过平滑肌细胞进行了血管反应，该模式通过弹性的近红外光谱光谱（FNIRS）测量。在TES期间，瞬态感觉可能会对血液动力学产生唤醒作用，因此我们提出了一个健康的病例系列，用于FNIRS的黑盒建模 - 短期TDCS效应的互化效果。块外生性测试拒绝了tdcs不是FNIRS总血红蛋白变化（HBT）和瞳孔扩张变化（p <0.05）的单步格兰格原因的说法（p <0.05）。Moreover, grey-box modeling using fNIRS of the tDCS effects in chronic stroke showed the HbT response to be significantly different (paired-samples t -test, p < 0.05) between the ipsilesional and contralesional hemispheres for primary motor cortex tDCS and cerebellar tDCS, which was subserved by the smooth muscle cells.在这里，我们的看法是，各种生理途径扩散TE的影响可能会导致状态特征变异性，这对于临床翻译而言可能具有挑战性。因此，我们使用我们的减少二维模型和随机，无衍生的协方差矩阵适应演化策略进行了一项案例研究。我们从计算分析中得出结论，在未来的研究中，在降低神经调节中的受试者间和受试者内变异性的未来研究中，对TE在护理点上的影响。
