•用于利用平行多词数据的统计方法将上游信号通路的失调与转录反应的改变联系起来(Osmanbeyoglu等人,基因组研究,2014年)•PAN-CANCER分析确定了突变对TF和(Phospho)蛋白质活性的影响(OSMANBEYOGLU ETICICTICATIC ENCORICTION,PSICINIC,2017),2017年。染色质),一种多任务回归框架,可预测染色质访问元件中转录因子(TF)结合基序的患者特异性基因表达谱。(Osmanbeyoglu# et al., Nature Communications , 2019 ) (#=co-corresponding authors) • CITRUS (C hromatin-informed I nference of T ranscriptional R egulators U sing S elf-attention mechanism), a partially interpretable neural network (NN) model with encoder-decoder architecture to link somatic alterations to transcriptional programs (Tao*, Ma* et al.,核酸研究,2022年)(对应作者)
• 原发性人类浸润性小叶和导管乳腺癌的染色质可及性景观和活性转录因子 (Lee, Osmanbeyoglu, Breast Cancer Research, 2022) • 综合多组学分析以了解雌激素受体 (ER) 介导的转录 (Osmanbeyoglu et al., BMC Genomics, 2012; Osmanbeyoglu et al., NAR, 2013; Watters et al., Mol. Cell. Endocrinol, 2017) • 综合多组学分析以表征 ER+乳腺癌模型对 PI3K 信号抑制剂的反应的表观基因组学和转录组学景观 (Toska, Osmanbeyoglu et al., Science, 2017)