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MUON空间简介小卫星星座
●我们认为缺乏对地球气候的知识，并且需要卫星观察来检测，监测和缓解气候变化的影响●我们的传统卫星观察系统仅限于一次性的班级班级任务和大型操作，并具有大量的操作，并具有缓慢的（破损/Div？）process to bring new and increasing quantities of observations online ● Recently, commercial small satellite constellations have been shown to be cost-effective alternatives for providing sustainable Earth observations ● With rapidly decreasing launch costs, small sats are replacing CubeSats, allowing larger platforms that can host more capable EO payloads and more payloads on a single satellite, while still being relatively inexpensive to launch ● Muon Space is building this small卫星星座解决方案
H2阻滞剂和质子泵抑制剂
◦ Given orally as enteric coated formulations (unstable in acidic medium in stomach) ◦ Pro-drugs (converted to the active form after administration in gastric gland -parietal cells-) ◦ Rapidly absorbed from the intestine then distributed in blood then activated in stomach ◦ Activated within the acidic medium of parietal cell canaliculi (the site of action) ◦ At neutral pH, PPIs are inactivated - 需要HCl（酸中） - ◦不应与H2阻滞剂结合 - 因为它们会抑制肝脏酶 - 或抗酸剂，因为它们减少了Hcl→PPIS灭活PPIS◦ppis◦食物→在食物中降低了一小时，而在一小时下降低了一小时的时间，在进餐前一小时，每日摄氏量很长一段时间。 CYT-P450（药物相互作用的原因）→严重肝衰竭需要减少
MKT4761K
Course Outline Course Code : MKT4761K Course Title : SIM: Marketing Technology Semester : Semester 1, AY 2024/2025 Faculty : Mr Alvin Tan Department : Marketing Email : tanalvin@nus.edu.sg URL : https://bschool.nus.edu.sg/marketing/faculty/ Overview Rapidly evolving technologies, like GenAI, are营销人员的双刃剑。当他们提供对MARTECH工具和解决方案的前所未有的访问时，他们也可以重塑消费者的行为和经验。公司越来越多地利用Martech（例如聊天机器人，AR/VR和Metaverse）来开发提供新客户价值的高科技接触点。本课程设计为Martech的营销人员指南，通过对最新的Martech工具和解决方案进行体验式学习来扩展客户旅程。通过实践研讨会和现实世界中的案例研究，您将学习如何评估和制定明天客户的有效Martech策略。课程的课程目标在本课程结束时，学生应该能够：
糖尿病 - 酮症酸和酮症 - 非酸 - 酸性...
•新发作的糖尿病•延长DKA的病史（几天）•糖尿病控制不良的延长病史导致慢性超色型•年龄<5•中度至多种酸中毒（血清pH <7.2）•bun脉升高•提供> 4L/M2/M2/M2/M2/M2/M2/M2/M2/M2/M2/M2/M2/M2/M2/M2/M2/M2/M2/M2•serum phum phum pl clum pl and plasmam and plasma and plasma and plasma and plasma and plasma and plasma。 replacement • Rate of decrease of serum glucose >100 mg/dL/hour • Failure of serum Na to increase as serum glucose decreases • Rapidly decreasing plasma osmolality or critically low plasma osmolality during the first 24 hours of therapy • Osmolality may be calculated as: Posm = 2 [NA+] + [Glucose]/18 +[BUN]/2.8.•建议遵循临床检查的血清OSM Q4H
EGFR-TKI组合疗法的临床进展用于EGFR突变的NSCLC：叙事评论
对NSCLC的肿瘤发生和进展的深入研究表明，大多数NSCLC患者的表皮生长因子受体（EGFR）的突变（5）。 egfr是一种跨膜酪氨酸激酶蛋白，正在成为NSCLC治疗的具有里程碑意义的靶标。 eGFR被受体过表达激活，这是各种癌症组织中的常见现象。 egfr的过表达，据报道它与乳房，肺，卵巢，宫颈，膀胱，食管，脑，头部和颈部癌症的侵略性和较差的临床结局有关（6-10）。 Additionally, EGFR activation and phosphorylation by the binding of the ligands, such as epidermal growth factor (EGF) (11), further activate several downstream signaling pathways, such as the rat sarcoma protein (Ras)/rapidly accelerated fibrosarcoma protein (Raf)/mitogen-activated protein kinases (MAPK), phosphatidylinositol-3激酶（PI3K）/蛋白激酶B（AKT）/哺乳动物雷帕霉素（MTOR），Janus激酶（JAK）/信号传感器和转录（STAT）途径激活剂（12）的靶标，在调节多个蜂窝过程中起着重要作用，在调节多个蜂窝过程中起着重要作用，包括繁殖，生存，生存，和apoptosis。对NSCLC的肿瘤发生和进展的深入研究表明，大多数NSCLC患者的表皮生长因子受体（EGFR）的突变（5）。egfr是一种跨膜酪氨酸激酶蛋白，正在成为NSCLC治疗的具有里程碑意义的靶标。eGFR被受体过表达激活，这是各种癌症组织中的常见现象。egfr的过表达，据报道它与乳房，肺，卵巢，宫颈，膀胱，食管，脑，头部和颈部癌症的侵略性和较差的临床结局有关（6-10）。Additionally, EGFR activation and phosphorylation by the binding of the ligands, such as epidermal growth factor (EGF) (11), further activate several downstream signaling pathways, such as the rat sarcoma protein (Ras)/rapidly accelerated fibrosarcoma protein (Raf)/mitogen-activated protein kinases (MAPK), phosphatidylinositol-3激酶（PI3K）/蛋白激酶B（AKT）/哺乳动物雷帕霉素（MTOR），Janus激酶（JAK）/信号传感器和转录（STAT）途径激活剂（12）的靶标，在调节多个蜂窝过程中起着重要作用，在调节多个蜂窝过程中起着重要作用，包括繁殖，生存，生存，和apoptosis。
基于硅的异质结构设备和电路
课程说明微电动设备和电路设计师长期以来一直在寻求结合带隙工程提供的卓越运输特性和设计灵活性（如在GAAS和INP等复合半导体中常规实践），以及高产量和较低的常规硅（SI）制造成本。随着介绍外延硅果（Sige）合金，这一梦想终于成为现实。SIGE异质结双极晶体管（SIGE HBT）是在SI材料系统中实现的第一个实用带段的实用设备。The first functional SiGe HBT was demonstrated in 1987, and the technology has matured rapidly, at present achieving a unity-gain cutoff frequency above 700 GHz, circuit delays below 2 picoseconds, and integration levels sufficient to realize a host of record-setting digital, analog, RF, mm-wave, and sub-mm-wave circuits.自然兼容，将SIGE HBT与最佳的SI CMO组成以形成SIGE HBT BICMOS技术，这显然适合于解决新兴的性能受限，高度集成的系统，目前正在商业和国防部门在全球范围内追求。
化学与生物防御计划（CBDP）
化学和生物防御计划（CBDP）对于我们国家应对化学和生物（CB）武器带来的当前和未来威胁的能力至关重要。CB威胁仍然很大，并且由于多个科学和快速技术发展的融合而以指数加速的速度扩展，去年表明，对响应式生物粘面能力的关键需求可以解决这些快速变化。在承认这一战略背景下，2020年CBDP企业战略建立了四个战略目标，以改善战士的准备和致命性，并与其他部门改革保持一致。这些是：未来战斗的计划，以速度交付，推动创新并优化企业。该战略同步了CBDP流程和行动，以确保企业与部门的改革保持同步，并在威胁之前保持稳定，同时为联合部队提供及时有效的CB防御能力。The office of the Deputy Assistant Secretary of Defense for Chemical and Biological Defense (ODASD(CBD)) continues to work across the Department to clarify roles and responsibilities, strengthen domestic and international partnerships, anticipate emerging CB threats, close today's gaps, and rapidly mitigate vulnerabilities, specifically challenges highlighted by the ongoing COVID-19 pandemic.战略概述
ECE 659智能传感器和传感器网络
作为用于创建内容的下一代范式，AI生成的内容（AIGC），即，基于用户提示，通过生成AI（GAI）自动构成内容，最近引起了极大的关注和成功。With the ever- increasing power of GAI, especially the emer- gence of Pretrained Foundation Models (PFMs) that contain billions of parameters and prompt engineering methods (i.e., finding the best prompts for the given task), the application range of AIGC is rapidly expanding, covering various forms of information for human, systems, and networks, such as network designs, channel cod- ing, and optimization solutions.在本文中，我们介绍了移动边缘AI生成的所有内容的概念（AIGX）。具体来说，我们首先回顾了AIGX的构建块，从AIGC到AIGX的演变以及实用的AIGX应用。然后，我们提出了一个统一的移动边缘AIGX框架，该框架采用边缘设备提供PFM授权的AIGX服务，并通过及时的工程优化此类服务。更重要的是，我们证明了次序提示导致发电质量差，这会对用户满意度，边缘网络性能和资源利用产生不利影响。因此，我们进行了一个案例研究，展示了如何使用Chatgpt培训有效的及时优化器，并研究了及时工程在用户体验，发电质量和净工作绩效方面进行的改进。
基于模型的工程 (MBE) 的最终报告...
Purpose Numerous recent studies and reports [3, 7, 8, 9, 10] have documented the increasing complexity of defense systems. The growth in complexity has increased risk and development time to the point where the time to field new systems and evolve existing systems is not acceptable. In addition, defense systems are operating in a rapidly changing environment, and the ability of systems to respond to those changes requires higher degrees of system adaptability. Traditional systems engineering methods, processes, and tools need significant improvement to meet the challenges posed by the increasing system complexity trend [10] , as do traditional software engineering methods [3]. Additionally, increasing complexity arising from the interdependence of large numbers of component suppliers is posing integration problems that challenge the limits of tradtional approaches [1]. Model Based Engineering (MBE) is an emerging approach to engineering that holds great promise for addressing the increasing complexity of systems, and systems of systems, while reducing the time, cost, and risk to develop, deliver, and evolve these systems. The purpose of this study was to assess the current state of MBE, identify the potential benefits, costs, and risks of MBE within the context of the DOD acquisition life cycle, and provide recommendations that would enable the widespread adoption of MBE practices across the DOD acquisition life cycle. Findings and General Recommendations MBE, as defined by the subcommittee, is an approach to engineering in which models:
大脑之间的串扰的最新进展 -
脑衍生的神经营养因子（BDNF）是大脑内的关键神经营养蛋白，通过选择性激活TRKB受体，对神经发育，突触可塑性，细胞完整性和神经网络动态产生多模式的影响。In parallel, glucocorticoids (GCs), vital steroid hormones, which are secreted by adrenal glands and rapidly diffused across the mammalian body (including the brain), activate two different groups of intracellular receptors, the mineralocorticoid and the glucocorticoid receptors, modulating a wide range of genomic, epigenomic and postgenomic events, also expressed in the神经组织，与神经发育，突触可塑性，细胞稳态，认知和情感处理有关。最近的研究证据表明，这两个主要的调节系统在各个层面上相互作用：它们具有共同的细胞内下游途径，GCS在某些条件下对BDNF的表达差异化，BDNF在某些条件下拮抗GC诱导的对长期增强的影响对长期增强对长期的影响，神经性出生和细胞死亡的影响，而GCS则在GCS进行了gccs interaneal and nistanal and and and and and and and and and and and and and and anfn。当前，BDNF-GC串扰特征主要在神经元中研究，尽管初始发现表明，对于其他脑细胞类型，例如星形胶质细胞，这种串扰可能同样重要。阐明BDNF-GC相互作用的精确神经生物学意义，以示波器方式进行，对于理解脑功能和功能障碍的微妙之处至关重要，对神经退行性和神经性衰弱和神经性疾病疾病，情绪疾病，情绪障碍，情绪和认知策略的影响至关重要。