DAM Day-Ahead Market EEA Energy Emergency Alert EOC Energy Offer Curve ERCOT Electric Reliability Council of Texas ERS Emergency Responsive Service HCAP High System-Wide Offer Cap HSL High Sustained Limit LCAP Low System-Wide Offer Cap LOLP Loss of Load Probability MCL Minimum Contingency Level NFRC Non-Frequency Responsive Capacity Non-Spin Non-Spinning Reserve ORDC Operating Reserve Demand Curve PBMCL Probability of Reserves Falling Below the Minimum Contingency Level PNM Peaker Net Margin PRC Physical Responsive Capability PUCT Public Utility Commission of Texas QSE Qualified Scheduling Entity QSGR Quick-Start Generation Resources RTM Real-Time Market RTOFFCAP Real-Time Off-Line Capacity RTOFFPA Real-Time Off-Line Reserve Price Adder RTOLCAP Real-Time On-Line Capacity RTORDPA Real-Time On-Line Reliability Deployment Price Adder RTORPA Real-Time On-Line Reserve Price ADDER RUC可靠性单元承诺SWCAP SWCAP范围内提供损失负载的上限VOLL值
1美国马里兰州医学院儿科,美国马里兰州21201; akowalski@som.umaryland.edu 2asociaciónpara la para la para ladevención y estudio del vih/sida,Retalhuleu 11001,危地马拉; valfonso@apevihs.org(v.a.m. ); shdepster@gmail.com(S.D.P.) 3美国马里兰州巴尔的摩市约翰·霍普金斯公共卫生学院国际卫生部,美国马里兰州21205; kaley.lambden@gmail.com(k.b.l.) 4美国马里兰州马里兰州医学院流行病学和公共卫生系,美国马里兰州21202; natilton@gmail.com 5美国俄亥俄州代顿市人类营养促进研究所,美国俄亥俄州45414; lisa@chispuditos.com(l.m.v. ); apalacios@georgiasouthern.edu(A.M.P. ); reinhart.greg@gmail.com(g.a.r。) 6 Jiann Ping HSU公共卫生学院,佐治亚州南部大学,乔治亚州州立大学,乔治亚州30458,美国7 RTI国际,研究三角公园,美国北卡罗来纳州27709,美国 *通信:mblack@som.umaryland.edu†这些作者对这项工作做出了同样的贡献。1美国马里兰州医学院儿科,美国马里兰州21201; akowalski@som.umaryland.edu 2asociaciónpara la para la para ladevención y estudio del vih/sida,Retalhuleu 11001,危地马拉; valfonso@apevihs.org(v.a.m.); shdepster@gmail.com(S.D.P.)3美国马里兰州巴尔的摩市约翰·霍普金斯公共卫生学院国际卫生部,美国马里兰州21205; kaley.lambden@gmail.com(k.b.l.) 4美国马里兰州马里兰州医学院流行病学和公共卫生系,美国马里兰州21202; natilton@gmail.com 5美国俄亥俄州代顿市人类营养促进研究所,美国俄亥俄州45414; lisa@chispuditos.com(l.m.v. ); apalacios@georgiasouthern.edu(A.M.P. ); reinhart.greg@gmail.com(g.a.r。) 6 Jiann Ping HSU公共卫生学院,佐治亚州南部大学,乔治亚州州立大学,乔治亚州30458,美国7 RTI国际,研究三角公园,美国北卡罗来纳州27709,美国 *通信:mblack@som.umaryland.edu†这些作者对这项工作做出了同样的贡献。3美国马里兰州巴尔的摩市约翰·霍普金斯公共卫生学院国际卫生部,美国马里兰州21205; kaley.lambden@gmail.com(k.b.l.)4美国马里兰州马里兰州医学院流行病学和公共卫生系,美国马里兰州21202; natilton@gmail.com 5美国俄亥俄州代顿市人类营养促进研究所,美国俄亥俄州45414; lisa@chispuditos.com(l.m.v. ); apalacios@georgiasouthern.edu(A.M.P. ); reinhart.greg@gmail.com(g.a.r。) 6 Jiann Ping HSU公共卫生学院,佐治亚州南部大学,乔治亚州州立大学,乔治亚州30458,美国7 RTI国际,研究三角公园,美国北卡罗来纳州27709,美国 *通信:mblack@som.umaryland.edu†这些作者对这项工作做出了同样的贡献。4美国马里兰州马里兰州医学院流行病学和公共卫生系,美国马里兰州21202; natilton@gmail.com 5美国俄亥俄州代顿市人类营养促进研究所,美国俄亥俄州45414; lisa@chispuditos.com(l.m.v.); apalacios@georgiasouthern.edu(A.M.P.); reinhart.greg@gmail.com(g.a.r。)6 Jiann Ping HSU公共卫生学院,佐治亚州南部大学,乔治亚州州立大学,乔治亚州30458,美国7 RTI国际,研究三角公园,美国北卡罗来纳州27709,美国 *通信:mblack@som.umaryland.edu†这些作者对这项工作做出了同样的贡献。6 Jiann Ping HSU公共卫生学院,佐治亚州南部大学,乔治亚州州立大学,乔治亚州30458,美国7 RTI国际,研究三角公园,美国北卡罗来纳州27709,美国 *通信:mblack@som.umaryland.edu†这些作者对这项工作做出了同样的贡献。
什么是教学法?......................................................................................................... 3 How Does Learning Happen?......................................................................................... 3 Early Learning for Every Child Today (ELECT) ............................................................... 5 TELCCS Play-Based Learning Model ............................................................................. 7 The Value of Play ............................................................................................................ 7 The Role of Registered Early Childhood Educators ........................................................ 8 Planned and Responsive Programs ................................................................................ 9 Children's Learning Environments ................................................................................... 9 Outdoor Play – A Critical Part of Learning ..................................................................... 10 Program Enrichments .................................................................................................... 10 Child Development ........................................................................................................ 11 Supportive Strategies .................................................................................................... 11
• Extensive consultation through the life-cycle of projects to ensure communicate with and are responsive to our communities, endeavoring to always act honestly and fairly • Indigenous Engagement Strategy to promote Indigenous employment and procurement for K2-Hydro • Strict focus on minimising disturbance, commitment to conserving and protecting the environments as illustrated by the “Recycling And Reuse Programme” • K2-Hydro converting disturbed mine可持续能源生成的网站•专注于我们当地社区的创造就业机会:在基德斯顿和传输路线上创造的900个工作
As well as reinforcing our brand and our values, all our communications will be: • driven by our Business Plan objectives and the needs of our customers, members and stakeholders • clear, honest, open and friendly • tailored to the target audience • accessible, in line with our audiences' needs • appropriately branded and professional • responsive, in line with the expectations of our customers and partners • inclusive, reflecting the diversity in our communities • proactive, with comprehensive and考虑了针对更大的项目和挑战的沟通计划,以确保我们正在思考
■ more emphasis will be given to developing relationships with trade and specialist press as well as increasing links with regional and national media outlets ■ resources will be managed in a way which enables the communications team to focus on producing high quality proactive and direct communications ■ day-to-day proactive and reactive media relations will focus on key decisions and local issues which link to council priorities ■ responsive work which does not work towards achieving strategic outcomes and goals will在情况下应处理■将介绍新闻发布会,以及有关关键问题的更具互动性论述■我们将增加视频版本和摄影的使用
• Ensure an educated, competent and motivated nursing and midwifery workforce within effective and responsive health systems at all levels and in different settings • Optimise policy development, effective leadership, management and governance • Maximise the capacities and potential of nurses and midwives through intra- and inter-professional collaborative partnerships, education and continuing professional development • Mobilise political will to invest in building effective evidence- based nursing and midwifery workforce 发展。WHO执行委员会已将2020年指定为“护士和助产士年”,以表彰护士和助产士对实现普遍健康覆盖范围(UHC)的基本和重要贡献,以及可持续发展的发展目标(SDGS)
背景与目的:顺铂-紫杉醇 (TP) 联合化疗作为多种癌症的一线治疗手段,因其在肿瘤内蓄积不充分及非特异性分布导致的严重副作用而受到阻碍。本研究旨在探索 TMTP1 修饰的顺铂和紫杉醇前药共载纳米药物是否能通过主动和被动的肿瘤靶向蓄积和控制药物释放来改善宫颈癌化疗并减轻其副作用。方法:制备具有主动靶向肿瘤和控制药物释放能力的 TDNP 来共同递送顺铂和紫杉醇前药。研究其特性,包括粒径、表面 zeta 电位、稳定性和肿瘤微环境 (TME) 依赖的药物释放曲线。在体内和体外评估细胞摄取、细胞毒性、肿瘤内药物蓄积、抗肿瘤作用和安全性分析。结果:氧化顺铂和连接在聚合物上的紫杉醇实现了超过80%的高载药率和TME依赖的缓释药物。此外,TMTP1修饰增强了TDNP的细胞摄取,进一步提高了TDNP的体外细胞毒性。在体内,在TMTP1的帮助下,TDNP在SiHa异种移植模型中表现出血液循环延长和蓄积增加。更重要的是,TDNP控制了肿瘤的生长,而没有危及生命的副作用。结论:我们的研究为宫颈癌的靶向化疗提供了一种新的TP共递送平台,有望提高TP的治疗效果,也可能应用于其他肿瘤。关键词:TME响应,靶向共递送,联合化疗,宫颈癌
目的:多功能药物递送系统 (DDS) 正在成为一种高效治疗恶性肿瘤的新策略。本研究旨在开发一种使用天然蛋白质铁蛋白 (FRT) 和纳米级氧化石墨烯 (NGO) 作为双载体的药物双载体递送系统 (DDDS)。方法:FRT 是一种具有拆卸和重组特性的 pH 敏感空心笼蛋白,NGO 具有较大的表面积和光热效应,可以在近红外辐射 (NIR) 下装载和释放药物。由于这些独特的特性,NGO 装载了抗癌药物白藜芦醇 (RSV) 和结合的线粒体靶向分子 IR780 作为第一个药物递送平台 IR780-NGO-RSV (INR)。接下来,INR 被 FRT 封装以形成 DDDS INR@FRT,用于卵巢癌的协同光热化疗。结果:通过一系列表征,INR@FRT 表现出均匀的纳米球结构和在生理条件下显著的稳定性。证实了热/pH 5.0 可触发 INR@FRT 释放 RSV。被细胞吸收后,INR@FRT 定位到溶酶体,酸性环境触发 INR 释放。INR 靶向线粒体并释放 RSV 直接与细胞器发生反应,进而降低线粒体膜电位并导致细胞凋亡。体内实验表明,INR@FRT 联合 NIR 照射表现出显著的肿瘤抑制作用,治疗 60 天后存活率很高。最后,在体内和体外证明了 INR@FRT 的生物相容性。结论:这些结果凸显了 INR@FRT 作为一种 DDDS 在治疗肿瘤方面的巨大潜力。关键词:白藜芦醇 细胞凋亡 双载体药物递送系统 线粒体靶向性 pH/热诱发肿瘤治疗
选定的承包商将与市政府工作人员和某些利益相关者合作推出社区营销,教育和外展活动,目的是在16周(16)周内确保60多个太阳能和/或电池存储安装的住宅和商业合同。安装预计将在2025年3月31日或之前完成所有安装的目标延续。All of the Initiative residential and commercial participants that enroll in the program will be exclusive leads advanced to the Selected Contractor, who will provide the services described in this RFP, including responsive participant communication, a transparent pricing/financing structure, accurate design and engineering proposals, and turnkey design and installation services
