抽象背景/目的:本研究的目的是设计和准备浮动原位凝胶,以维持卡维迪尔(CVD)释放并增强口服生物利用度。通过离子凝胶法制备了CVD的各种浮动原位凝胶制剂。材料和方法:采用制剂设计中的系统方法,使用羟丙基甲基纤维素(HPMC K4M),羟丙基纤维素(HPMC 100LV),硫酸钠,含Mimosa pudica pudica seed MiCOSIMA酸酸盐酸(SODICA)与各种浓度(SODICASIMA GIMACISMA gymoma gymoma gymoma gymoma gymoma gymoma gymoma,研究了碳酸氢盐的物理化学特性(体外浮动行为,药物释放概况等)。随后,基于物理化学特性涉及最终优化步骤,以实现所需的效果。结果:基于研究,HPMC K4M,HPMC 100LV,藻酸钠和Mimosa Pudica种子粘液(F17)表现出良好的浮动特性(60秒sec浮动滞后时间),药物释放的药物为96.98±2.1%,释放了12小时,该药物释放的序列均释放为ZERO,并释放了序列。在白化兔中F17的体内X射线研究表现出良好的浮动能力,最大为8小时。发现优化和对照(CARLOC)的生物利用度分别为41.95±0.8892μg.hr/ ml和26.36±1.1603μg.hr/ ml。用优化的配方进行了加速稳定性研究,并在研究期间观察到稳定。结论:得出结论,用天然聚合物开发的Carvedilol的原位原位凝胶适合GRDDS增强口服生物利用度。
皮尔士的符号学与认知过程相关,它被视为一个涉及三元组对象、符号和解释项的连续过程,其中解释项成为后续符号过程的新符号。认知过程被描述为一个动态系统,其中每个认知在逻辑上由先前的认知决定(Peirce 1868,W 2:213,EP 1:30),这与符号学中符号的无限链接非常相似。在 C. S. Peirce 的哲学体系中考虑的这种过程包括联觉学说,即心脑连续性学说,使得将一定水平的认知甚至一定水平的意识融入嵌入人工智能算法(尤其是深度学习)的计算系统。
CHIPS Act and its Impact on the Compound Semiconductor Industry Melissa Grupen-Shemansky, PhD 1 1 CTO and VP of Technology Communities, SEMI, megshemansky@semi.org Keywords: CHIPS, Manufacturing, Workforce, Supply Chain, Compound Semiconductor, Government Abstract SEMI, in their 50+ years of operation, has been a trade organization supporting the semiconductor manufacturing industry with a strong membership population consisting of materials and equipment suppliers from its onset. In the mid 90's, membership jumped and SEMI broadened their scope to include member companies from across the semiconductor manufacturing supply chain, such as IDMs (integrated device manufacturers), foundries (outsource fabrication service suppliers), and EDA (electronic design automation) suppliers. We have not deviated from our base, but have added membership from across the supply chain recognizing the increasing complexity of the microelectronics ecosystem and the increasing demand for co-design and cross-collaboration of the various semiconductor disciplines at the earliest stages of development. The semiconductor industry has experienced various inflection points over the last several decades, but perhaps none so disruptive as the present. We will look into how the semiconductor industry in general has captured the attention of the person on the street and how the industry disruptions will lead to opportunities for compound semiconductors. The U.S. CHIPS and Science Act will accelerate More than Moore technologies which in turn will further enable the integration of compound semiconductors to capitalize on the unique properties of these materials. Breakthrough opportunities will emerge with the emerging technologies developed in the Microelectronics Commons as well as the priorities of the National Semiconductor Technology Center (NSTC) and closely coupled National Advanced Packaging Manufacturing Program (NAPMP) in the CHIPS Act R&D office. A rapid focus on those technologies essential to U.S. market leadership will ensue. We will examine the emerging priorities within the CHIPS Act programs and discuss the critical role compound semiconductors play in the leap ahead technologies as well as the potential supply chain vulnerabilities that need to be addressed. I NTRODUCTION As the semiconductor industry prepared to navigate a dramatic change to the traditional linear shrink roadmap that had affirmed Moore's Law for the last 40 years, the COVID pandemic hit. Most people, companies, and countries were caught off guard and ill-prepared. In a rush to save lives,
电子产品说明 - 修订中的供应链要素(目前正在投票) IPC-1782 合规标准或指南(包括审计清单) SEMI E142 基板映射规范 SEMI E142 合规标准或指南(包括审计清单) SEMI 6504 - 外部设备可追溯性规范 SEMI 6504 合规标准或指南(包括审计清单) IPC-1783 - 元器件级认证国际标准
摘要 绿色革命基于赤霉素 (GA) 激素系统的遗传改造,通过“矮化”基因突变降低 GA 信号,使植物矮化,从而使植物适应现代农业条件。矮化的强 GA 相关突变体往往胚芽鞘长度缩短,由于干旱条件下幼苗出苗效果不佳,导致产量降低。这里我们提出赤霉素 (GA) 3-氧化酶 1 (GA3ox1) 作为大麦的另一种半矮化基因,它既能最佳地降低植物高度,又不限制胚芽鞘和幼苗的生长。通过对大量大麦种质进行大规模田间试验,我们发现天然的 GA3ox1 单倍型可适度降低植物高度 5 – 10 厘米。我们使用 CRISPR/Cas9 技术,生成了几个新的 GA3ox1 突变体并验证了 GA3ox1 的功能。我们发现,改变 GA3ox1 活性会改变活性 GA 异构体的水平,从而使胚芽鞘长度平均增加 8.2 毫米,这可以为在气候变化下保持产量提供必要的适应性。我们发现 CRISPR/Cas9 诱导的 GA3ox1 突变将种子休眠期增加到理想水平,这可能有利于麦芽行业。我们得出结论,选择 HvGA3ox1 等位基因为开发具有最佳身高、更长胚芽鞘和额外农艺性状的大麦品种提供了新的机会。
(1)西班牙工业装配公司,SA DBA SEMI (2)Ferrovial Agroman SA (3)Eiffage Group UTE (4)Dragados 有限公司 (5)Constructora San Jose SA (6)UTE Castellano Cobra MACC (7)Acciona CMS JV,LLC
密钥组件,模块,半端设备制造服务的系统。半相关的设备,备件和维修服务R&D,销售以及半设备的总解决方案提供商医疗成像设备制造和设计服务。
2022-2024 年 ISCCM 秘书长 2024 年加尔各答 CRITICARE 组织秘书长 2019-2021 年印度重症监护医学院认证秘书 2016-2018 年 ISCCM 副主席 2013-2015 年 ISCCM 执行委员 2013-2015 年指导委员会成员 2013-2017 年财务委员会成员 2010-2012 年北区执行委员 2009-2011 年 ISCCM 密拉特分会秘书 由 ISCCM、ISA (印度麻醉师协会) 和 SEMI (印度急诊医学协会) 组织的全国性和地区性会议、CME、研讨会的教员 我在各种国家和国际期刊上发表了 23 篇出版物,并为书籍的 15 个章节做出了贡献,并且担任多本书籍的编辑 我以各种身份积极参与组织许多研讨会和 CME 为“空间技术推动的质量升级 (QUEST)”计划做出贡献,该计划是印度空间研究组织 (ISRO)、认可的医疗保健组织联盟 (CAHO)、国家医院和医疗保健提供者认证委员会 (NABH)、印度急诊医学协会 (SEMI) 和印度重症监护协会 (ISCCM) 共同发起的。