Yoshimitsu Nakanishi,1,2,3,4,18 Mayuko Izumi,1,2,2,3,4,18 Hiroaki Matsushita,3,5 Yoshihisa koyama,4,6,6,6 diego diez,7 dieoge diez,8 hyota takamatsu,8 hyota takamatsu,1,2 shohei koyama,1 shehei koyama,1 yumay 1,2 yumay 1,2 yum 1,2 Yumy 1,2 Yum.2 Yumiik,1,1,2 Yuta Yamaguchi,1,2 Tomoki Mae,1 Yu Noda,1 Kamon Nakaya,1 Satoshi Nojima,9 Fuminori Sugihara,10 Daisuke Okuzaki,4,11,11,12,12,15,15,15 Mashito,13 ,19, * 1呼吸医学和临床免疫学系,大阪大学,大阪大学565-0871,日本2号免疫病理学系,世界首要国际研究中心免疫研究中心倡议倡议中心研究中心(WPI-IFREC) Chugai Pharmaceutical Co. Ltd.研究部门有限公司,在247-8530,日本6神经科学与细胞生物学系,大阪大学医学研究生院,大阪565-0871,日本7成瘾研究单位,大阪精神病学研究中心,大阪医学中心,大阪大学,osaka apai Osaka 565-0871,日本10生物功能成像实验室,意愿单细胞基因组学),WPI-IFREC,大阪大学,大阪大学565-0871,日本12基因组信息研究中心,研究所研究所(RIMD),大阪565-0871,OSAKA 13 565-07,大阪大学565-0871,日本15号教育与研究中心(CIDER),大阪大学,大阪565-0871 NOLOGY(AMED- CRIEST),大阪大学,大阪大学565-0871,日本日本17号高级模态和DDS(CAMAD),Osaka 565 CORS
Luregan J. Schlapbach,医学博士; R. Scott Watson,医学博士,MPH;劳伦·R·索尔斯(Lauren R. Sorce)博士,RN; Andrew C. Argent,医学博士,MBCH,MMED;医学博士Kusum Menon,MSC;马克·霍尔(Mark W. Hall),医学博士; Samuel Akech,MBCHB,MMED,博士; David J. Albers博士;伊丽莎白·R·阿尔珀恩(MSCE);医学博士Fran Balamth,MSCE; Melania Bembea,医学博士;医学博士Paolo Biban; Enitan D. Carrol,MBCHB,医学博士;医学博士Kathleen Chiotos; Mohammod Jobayer Christi,MBBS,MMED,博士;彼得·E·德威特(Peter E. Dewitt),博士;伊德里斯·埃文斯(Idris Evans),医学博士,MSC; CládioFlauzinode Oliveira,医学博士;克里斯托弗·霍瓦特(Christopher M. Horvat),医学博士,MHA; David Inwald,MB,博士;保罗·伊西米米(Paul Ishimine),医学博士; Juan Camilo Jaramillo-Bustante,医学博士;迈克尔·莱文(Michael Levin),医学博士; Rakesh Lodha,医学博士;医学博士Blake Martin; Simon Nadel,MBBS;马里兰州Satoshi Nakagawa;马克·J·彼得斯(Mark J. Peters),博士; Adrienne G. Randolph,医学博士,MS; Suchitra Ranjit,医学博士;玛格丽特马萨诸塞州的让伯;塞思·罗素(Seth Russell),女士;医学博士Halden F. Scott; Daniela Carla de Souza,医学博士; Pierre Tissiers,MD,DSC; MSCE医学博士Scott L. Weiss; Matthew O. Wiens,Pharmd,PhD; James L. Wynn,医学博士;医学博士Niranjan Kissoon; Jerry J. Zimmerman,医学博士; L. Nelson Sanchez-Pinto,医学博士; MS的Tellen D. Bennett,医学博士;对于重症监护社会,医疗小儿脓毒症定义工作队 div>
Altair (JuneSang Lee) AMD (Xilinx) (Bassam Mansour) Analog Devices Jermaine Lim-Abroguena Ansys Curtis Clark* Ansys Japan Satoshi Endo Applied Simulation Technology (Fred Balistreri) Aurora System (Dian Yang), Raj Raghuram Broadcom (Yunong Gan) Cadence Design Systems Kyle Lake, Ambrish Varma,贾里德·詹姆斯(Jared James),约翰·菲利普斯(John Phillips),克里斯托弗·斯凯特·塞抗阿(Sophia Feng)思科系统(Stephen Scearce),Hong-Man Wu Dassault Systemes(Stefan Paret)GE Healthcare Technologies(Balaji Sankarshanan) Telecomunicações (Abdelgader Abdalla) Intel Corporation Michael Mirmak*, Hsinho Wu*, Kinger Cai, Chi-te Chen Keysight Technologies Pegah Alavi, Ming Yan, David Banas, Fangyi Rao, HeeSoo Lee, Heidi Barnes Marvell Steven Parker* MathWorks Graham Kus*, Walter Katz* Micron Technology Justin Butterfield MST EMC Lab Chulsoon Hwang*, Zhiping Yang* Siemens EDA Weston Beal*, Arpad Muranyi*, Randy Wolff*, Matt Leslie, Scott Wedge, Todd Westerhoff, Zhichao Deng STMicroelectronics Anil-Kumar Dwivedi, Bhupendra Singh, Harsh Saini, Hemant Kumar Gangwar, Manda Padma Sindhuja,Manish Bansal,Nitin Kumar,Olivier Bayet,Pawan Verma,Pranav Singh,Pranav Singh,Rahul Kumar,Raushan Kumar,Shivam Soni,Shivam Soni,Gaurav Goel Synopsys Ted Mido*,(Andy Tai)中兴公司(中敏WEI),(Shunlin Zhu)Zuken(RalfBrüning)Zuken USA Lance Wang*
FULLNAME CITIZENSHIP PROGRAM FULL NAME ADVISOR Yeteng Tian China Bioscience Mo Li Giuseppina Rosaria Briola Italy Bioscience Alfredo De Biasio Laura Sudupe Medinilla Spain Bioscience David Gomez-Cabrero Bothina Hussein Algashgari Saudi Arabia Bioscience Peiying Hong Lubna Fahad Alhudhali Saudi Arabia Bioscience Samir Hamdan Olga Douvropoulou Greece Bioscience Arnab Pain Mansour Mohammed Aldehaiman Saudi Arabia Bioscience Jasmeen Merzaban Wiam Fawzi Alsharif Saudi Arabia Bioscience Heribert Hirt Fatimah Rajeh Aljedaani Saudi Arabia Bioscience Ikram Blilou Nathaly Rodriguez Ortiz Colombia Bioscience Mark Alfred Tester Ainur Sharip Kazakhstan Bioscience Stefan Theodor Arold Radwa Kadry Kamel Egypt Bioscience Magdy M Mahfouz Ioannis Isaioglou Greece Bioscience Jasmeen Merzaban Arwa Alghuneim Saudi Arabia Bioscience Jasmeen Merzaban Abdullah Abdurahman Alghamdi 沙特阿拉伯 生物科学 Satoshi Habuchi Francisco Javier Guzman Vega 墨西哥 生物科学 Stefan Theodor Arold Abdulrahman Awad Alhabsi 沙特阿拉伯 生物科学 Magdy M Mahfouz Abdulelah Ahmad Alrashoudi 沙特阿拉伯 生物科学 Stefan Theodor Arold Aseel Othman Alsantely 沙特阿拉伯 生物科学 Rod Anthony Wing Amal Khalaf Alghamdi 沙特阿拉伯 生物科学 Heribert Hirt Dana Mohammed Al Kelabi 沙特阿拉伯 生物科学 Niveen Mohammad Khashab Gian Marco Messa 意大利 生物科学 Valerio Orlando Raushan Nugmanova 哈萨克斯坦 生物科学 Arnab Pain Hattan Ageel Boshah 沙特阿拉伯 生物科学 Fabian Schmidt Zenaida Stephania Stead 英国 生物科学 Arnab Pain Caroline Faith Askonas 美国 生物科学 Arnab Pain
Yang Shen, Yan-Qing Li,* Kai Zhang, Liu-Jiang Zhang, Feng-Ming Xie, Li Chen, Xiao-Yi Cai, Yu Lu, Hao Ren, Xingyu Gao, Haijiao Xie, Hongying Mao, Satoshi Kera, Jian-Xin Tang,* Multifunctional Crystal Regulation Enables Efficient and Stable Sky-Blue Perovskite Light-Emitting Diodes, Advanced Functional Materials 2022 , 32, 2206574. Hao Ren, Yunlong Ma, Hui-Min Liu, Jing-De Chen,* Ye-Fan Zhang, Hong-Yi Hou, Yan-Qing Li, Qingdong Zheng,* Jian-Xin Tang,* Absorption Spectrum-Compensating Configuration Reduces the Energy Loss of Nonfullerene Organic Solar Cells, Advanced Functional Materials 2022 , 32, 2109735. Ruiman Ma, Jiawei Zheng, Yu Tian, Can Li, Benzheng Lyu, Linyang Lu, Zhenhuang Su, Li Chen, Xingyu Gao, Jian-Xin Tang,* Wallace C. H. Choy,* Self-Polymerization of Monomer and Induced Interactions with Perovskite for Highly Performed and Stable Perovskite Solar Cells, Advanced Functional Materials 2022 , 32, 2105290. Xiaoyan Qian, Yang Shen, Liu-Jiang Zhang, Minglei Guo, Xiao-Yi Cai, Yu Lu, Huimin Liu, Ye-Fan Zhang, Yanqing Tang, Li Chen, Yingyi Tang, Jingkun Wang, Wei Zhou, Xingyu Gao, HongYing Mao, Yanqing Li,* Jian-Xin Tang,* Shuit-Tong Lee,* Bio-Inspired Pangolin Design for Self- Healable Flexible Perovskite Light-Emitting Diodes, ACS Nano 2022 , 16 (11), 17973-17981. Kai Zhang, Long-Xue Cao, Yingyi Tang, Yi Yu, Yang Shen, Bingfeng Wang, Wen-Jun Wang,* Yan- Qing Li,* Jian-Xin Tang,* Blue Halide Perovskite Materials: Preparation, Progress, and Challenges, Laser Photonics Reviews 2022 , 2200689
Eduard Antonie van Bodegraven, MD, PhD, * † Sanne Lof, MD, PhD, * † Leia Jones, BSc, ‡ Béatrice Aussilhou, MD, PhD, § Gao Yong, MD, PhD, ∥ Wei Jishu, MD, PhD, ∥ Rosa Klotz, MD, PhD, ¶ Dario Missael Rocha-Castellanos, MD, PhD, # Ippei Matsumato, MD, PhD, ** Charles de Ponthaud, MD, PhD, †† Kimitaka Tanaka, MD, PhD, ‡‡ Esther Biesel, MD, PhD, §§ Emmanuele Kauffmann, MD, PhD, ∥∥ Traian Dumitrascu, MD, PhD, ¶¶ Yuichi Nagakawa, MD, PhD, ## Pablo Martí-Cruchaga, MD, PhD, *** Geert Roeyen, MD, PhD, ††† Alessandro Zerbi, MD, PhD, ‡‡‡ Mara Goetz, MD, PhD, §§§ Vincent E. de Meijer, MD, PhD, ∥∥∥ Patrick Pessaux, MD, PhD, ¶¶¶ Povilas Ignatavicius, MD, PhD, ### Ihsan Ekin Demir, MD, PhD, **** Mario Giuffrida, MD, PhD, †††† Bobby Tingstedt, MD, PhD, ‡‡‡‡ Marco Vito Marino, MD, PhD, §§§§ Sotiris Mastoridis, MD, PhD, ∥∥∥∥ Maximilian Brunner, MD, PhD, ¶¶¶¶ Isabel Mora-Oliver, MD, PhD, #### Cecilia Bortolato, MD, PhD, ***** Aisté Gulla, MD, PhD, ††††† Thomas Apers, MD, ‡‡‡‡‡ Hélène Hermand, MD, § Yusuke Mitsuka, MD, PhD, ## Irinel Popescu, MD, PhD, ¶¶ Ugo Boggi, MD, PhD, ∥∥ Uwe Wittel, MD, PhD, §§ Satoshi Hirano, MD, PhD, ‡‡ Sébastien Gaujoux, MD, PhD, †† Keiko Kamei, MD, PhD, ** Carlos Fernández-Del Castillo, MD, PhD, # Thilo Hackert, MD, PhD, ¶§§§§§ Jiang Kuirong, MD, PhD, ∥ Miao Yi, MD, PhD, ∥ Alain Sauvanet, MD, PhD, § Marc Besselink, MD, PhD, * † Mohammad Abu Hilal, MD, PhD, ‡ Sa fi Dokmak, MD, PhD, § ✉ and for the European Consortium on Minimally Invasive Pancreatic Surgery and the International Consortium on Minimally Invasive Pancreatic Surgery
Eduard Antonie van Bodegraven, MD, PhD, * † Sanne Lof, MD, PhD, * † Leia Jones, BSc, ‡ Béatrice Aussilhou, MD, PhD, § Gao Yong, MD, PhD, ∥ Wei Jishu, MD, PhD, ∥ Rosa Klotz, MD, PhD, ¶ Dario Missael Rocha-Castellanos, MD, PhD, # Ippei Matsumato, MD, PhD, ** Charles de Ponthaud, MD, PhD, †† Kimitaka Tanaka, MD, PhD, ‡‡ Esther Biesel, MD, PhD, §§ Emmanuele Kauffmann, MD, PhD, ∥∥ Traian Dumitrascu, MD, PhD, ¶¶ Yuichi Nagakawa, MD, PhD, ## Pablo Martí-Cruchaga, MD, PhD, *** Geert Roeyen, MD, PhD, ††† Alessandro Zerbi, MD, PhD, ‡‡‡ Mara Goetz, MD, PhD, §§§ Vincent E. de Meijer, MD, PhD, ∥∥∥ Patrick Pessaux, MD, PhD, ¶¶¶ Povilas Ignatavicius, MD, PhD, ### Ihsan Ekin Demir, MD, PhD, **** Mario Giuffrida, MD, PhD, †††† Bobby Tingstedt, MD, PhD, ‡‡‡‡ Marco Vito Marino, MD, PhD, §§§§ Sotiris Mastoridis, MD, PhD, ∥∥∥∥ Maximilian Brunner, MD, PhD, ¶¶¶¶ Isabel Mora-Oliver, MD, PhD, #### Cecilia Bortolato, MD, PhD, ***** Aisté Gulla, MD, PhD, ††††† Thomas Apers, MD, ‡‡‡‡‡ Hélène Hermand, MD, § Yusuke Mitsuka, MD, PhD, ## Irinel Popescu, MD, PhD, ¶¶ Ugo Boggi, MD, PhD, ∥∥ Uwe Wittel, MD, PhD, §§ Satoshi Hirano, MD, PhD, ‡‡ Sébastien Gaujoux, MD, PhD, †† Keiko Kamei, MD, PhD, ** Carlos Fernández-Del Castillo, MD, PhD, # Thilo Hackert, MD, PhD, ¶§§§§§ Jiang Kuirong, MD, PhD, ∥ Miao Yi, MD, PhD, ∥ Alain Sauvanet, MD, PhD, § Marc Besselink, MD, PhD, * † Mohammad Abu Hilal, MD, PhD, ‡ Sa fi Dokmak, MD, PhD, § ✉ and for the European Consortium on Minimally Invasive Pancreatic Surgery and the International Consortium on Minimally Invasive Pancreatic Surgery
为了澄清控制雄性小鼠社会偏好的神经回路,Takeawa Satoshi使用光遗传学和化学遗传技术来检查雌激素β受体(ERβ)表达细胞的操纵的影响,这表达了内侧杏仁核(MEA)(MEA)对雌性小鼠的偏好。摘要如下: 在第1章中,作者总结了性类固醇激素对雄性小鼠社会偏好的影响,作为基于先前研究的本文的背景。 Here, the authors state that male mice can identify females in estrus that are suitable for sexual behavior based on olfactory information, and generally prefer females (RF) over non-estrus (XF) and other male individuals (IM), but prior studies have shown that when the ERβ gene of MeA is missing, preference between RF and XF, that is, preference based on female estrus, is inhibited, while preference between RF and IM, that is, preference based on gender, is not inhibited.作者指出,先前研究的结果仅指ERβ蛋白的功能,并且尚未阐明基于发情状态的女性偏好的神经回路基础。考虑到这些背景,作者指出,本文的总体目的是了解集中在MEA背面的ERβ阳性神经元如何调节雄性小鼠的两种偏好:基于女性的偏好和基于性别的偏好。在第2章中,作者解释了一般程序,并同时创建了ERβ-ICRE小鼠应变,这对于实现上述目标至关重要,使用CRISPR-CAS9系统。使用该小鼠将使实验能够在社交偏好测试中专门记录和操纵MEA-ERβ细胞。 在第3章中,作者描述了将纤维光度法应用于ERβ-ICRE小鼠的实验(实验1和2)。首先,在实验1中,作者透露,在“女性雌激素”偏好测试中记录MEA-ERβ细胞的神经活性,该测试在搜索RF时强烈激活MEA-ERβ细胞,并指出MEA-ERβ细胞会特别响应RF异常和显示出偏好的伴侣的可能性。接下来,在实验2中,作者指出,MEA-ERβ细胞专门用于RF。
我们预测,只有在两种蛋白质结合时,就会存在一个独特的分子,并且从使用分裂 - 涡轮注释3进行的分析中,我们还发现,许多转录调节剂与该复合物结合起作用。从以上结果来看,已经揭示了BOD1L与setD1a结合,并且比作为DNA修复调节剂更有帮助癌症生长和生存的转录启动子。 ■研究人员的评论(Chiba University医学研究生院Hoshii副教授)我们很高兴能够解决蛋白质 - 蛋白质相互作用的奥秘,这些蛋白质相互作用已经很长时间了。 SETD1A本身也引起了人们的关注,作为儿童疾病和精神分裂症的原因,因此我们希望这一发现将有助于癌症以外的其他疾病的治疗。 ■词汇表注释1)CRISPR平铺方法:一种通过设计基因编辑技术CRISPR/CAS9中用于单个基因的无数SGRNA来全面检查和识别在蛋白质上具有功能的位置的方法。注2)DEPMAP数据库:一个数据库,旨在鼓励发现癌症治疗靶标和开发治疗方法,以1,000多个癌细胞系进行的大规模CRISPR-CAS9筛选的结果。注3)分裂 - 涡轮增压:一种接近依赖性的标记方法,允许识别其周围蛋白质的标记,仅限于两种蛋白质相互作用时。 ■Paper information Paper title: BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A Author: Takayuki Hoshii*, Sota Kikuchi, Tomoya Kujirai, Takeshi Masuda, Tomoko Ito, Satoshi Yasuda, Makoto Matsumoto, Bahityar Rahmutulla, Masaki Fukuyo,Takeshi Murata,Hitoshi Kurumizaka,Atsushi Kaneda *负责作者杂志名称:核酸研究doi:10.1093/nar/gkae605■参考材料1纸张1个纸张标题:SetD1A的非静脉功能调节setd1a的非催化功能。 10.1016/j.cell.2018.01.032■参考材料2纸张标题:setD1a在白血病杂志中调节血红素生物合成基因的转录暂停释放杂志名称:细胞报告DOI:10.1016/j.cellep.2022.1111727
2024卫生部只要引用源而不是出售或任何商业目的,就允许该工作的部分或全部复制。对本工作的文本和图像版权的责任来自Conitec。卫生科学,技术,创新与卫生综合体的准备,分销和信息部 - 卫生技术管理与成立套学部 - DGITS-总体卫生技术评估 - 部委的CGATS ESPLANADA,CEP 8楼G街8楼:70.058-900 -Brasília/df tel。:(61)3315-2848网站:https://www.gov.br/conitec/pt-br e-mail:conitec@saude.gov.br卫生技术评估中心心脏病学研究所(NATS/INC)Alex da Silva Itaborahy andraborahy andraborahy ander anber brersressa arawo dairage and healthy技术评估中心的准备SILVA MAGLIANO DANIEL ANDRIES GIGLIOTTI LENYSLAINE FROSSARD MARISA DA SILVA SANTOS TARICONE的SOUZA MATTHEW DENISHI KOMODA评论-CGATS/DGITS/SECTICS/SECTICS/MS LUCIANA COSTA COSTA CITEC/DGITS/SECTICS/MS Aérica de Figueiredo Pereira Meneses Andrea Brígida de Souza Andrija Oliveira Almeida Luiza Losco Losco Technological Horizon Aila Coelho do Carmo - Cgats/Dgits/Sectics/MS Daniele de Almeida Cardoso - CGATS/DGITS/MS Joana Ferreira da Silva - cgats/dgits/sectics/ms