检测抗菌和毒力因子的存在(或不存在)抗菌易感性分析多核序列分型(MLST)以及某些物种中的某些物种在硅血清型中的比较生物信息学和基因组学途径质粒分析(质体识别型的遗传范围)的分析(分析)的特定基因(分析)的特定基因(分析)的特定基因(分析)的特定基因(分析)数据)全基因组关联研究(GWAS)
2024年12月19日,生物北极亚宣布,生物北极亚已与Bristol Myers Squibb签订了一项全球许可协议,在该协议下,Bristol Myers Squibb将全球范围内的开发以及随后的BAN1503和BAN2803和全球关联产品的任何商业化负责。该协议受美国反托拉斯立法(1976年的Hart-Scott-Rodino Antrust Revers Act Act),该条件已实现,交易现已结束。该协议的最终确定触发了生物含量1亿美元的前期付款。该许可协议进一步包括开发,监管和商业里程碑的12.5亿美元,以及针对全球产品销售的分层的低两位数特许权使用费。Bioarctic将保留在北欧地区共同商业化产品的选项。生物二氧化碳-Aβ抗体程序由针对特定截短的焦谷氨酸修饰形式的新型抗体组成。pyroglu-aβ的单体很容易骨料,导致有害骨料的形成,导致阿尔茨海默氏病的认知和其他症状使人衰弱。 该协议包括BAN1503和BAN2803抗体。 BAN2803包括生物北极的BrainTransporter™技术。 “我很高兴我们获得了许可,允许我们与Bristol Myers Squibb达成协议,” Bioarcoric首席执行官Gunilla Osswald说。很容易骨料,导致有害骨料的形成,导致阿尔茨海默氏病的认知和其他症状使人衰弱。该协议包括BAN1503和BAN2803抗体。BAN2803包括生物北极的BrainTransporter™技术。“我很高兴我们获得了许可,允许我们与Bristol Myers Squibb达成协议,” Bioarcoric首席执行官Gunilla Osswald说。“他们对帮助阿尔茨海默氏病的患者有着热情,我们现在有可能探索Braintransporter技术的潜力,可以推进和优化阿尔茨海默氏病的下一代治疗方法。”与Bristol Myers Squibb的协议是与Braintansporter
Biopharma、SyneosHealth、Incyte、Bristol Myers Squibb。Care Dx、Bristol Myers Squibb、Incyte、Abbvie、CTI、Kite、Tscan、Morphosys、Karyopharm 等公司均参与了顾问委员会。
与Bristol Myers Squibb提出的Mirati的拟议收购有关,Mirati打算提交初步和确定的代理陈述。在与拟议的收购有关的特别会议之前,确定的代理声明和代理卡将交付给Mirati的股东。本文档不能替代代理声明或Mirati向SEC提交的任何其他文件。Mirati的股东和投资者在可用的情况下全部阅读确定的代理声明,以及Bristol Myers Squibb和Mirati向SEC提交的任何其他文件,与拟议的收购或通过参考有关的纳入SEC,因为它们将包含有关拟议的收购以及拟议收购的重要信息。投资者和安全持有人将能够免费获得代理声明的免费副本,以及此类文件,其中包含有关Bristol Myers Squibb和Mirati的重要信息,一旦通过SEC在www.sec.gov上维护的网站向SEC提交了此类文件。Bristol Myers Squibb和Mirati在Bristol Myers Squibb的网站www.bms.com/investors和Mirati的网站上分别免费提供,分别在www.ir.mirati.com上提供,它们用它们提交的材料或提供给SEC的材料的副本。
发表作者披露:Spira博士报告Incyte,Amgen,Novartis,Mirati Therapeutics,Gritstone,Gritstone,Jazz Pharma,Takeda,Janssen,Mersana,Mersana,Daiichi Sankyo,Array Biopharma,Astray Biopharma,Astray Biopharma,Astrazeneca,Merck,Bristol Myers Myers Myers Squibb,squibb,squibb,blueprintines;从Cytomx Therapeutics,Janssen Ortho和Bayer获得酬金; research funding from LAM Therapeutics, Roche, AstraZeneca, Boehringer Ingelheim, Astellas, MedImmune, Novartis, Newlink Genetics, Incyte, AbbVie, Ignyta, Trovagene, Takeda, Macrogenics, CytomX Therapeutics, Astex Pharma, Bristol Myers Squibb, Loxo Oncology, Arch Therapeutics, Gritstone,Plexxikon,Daiichi Sankyo,ADCT,Janssen Ortho,Mirati Therapeutics,Rubius,Cynthekine,Mersana,Mersana,Blueprint Medicines,Kezar和Revolution;下一个肿瘤学的首席执行官;并在Eli Lilly拥有股票/股份。
披露:Malka博士获得了Amgen,Bayer,Ipsen,Merck,Merck Serono,Roche,Sanofi和Servier的酬金和非财务支持;以及来自Shire,Haliodx和Agios的Honoraria。Siebenhüner博士没有竞争利益;他曾在咨询委员会任职,并获得了Amgen,Bayer,Bristol-Myers Squibb,Ipsen,Lilly,Lilly,Merck,Pfizer,Sanofi,Sanofi和Servier的咨询酬金,并获得了本研究以外的工作。 Mertens博士从Bristol-Myers Squibb,Bayer,Eisai,Gilead,Incyte,Intercept,Ipsen,Ipsen,MSD,Roche,Sanofi和Sigmatau担任咨询咨询奖。曾是Janssen,Incyte,Roche,Astrazeneca的发言人局成员;曾在Bristol-Myers Squibb,MSD,Amgen,Roche,Roche,Astrazeneca,Incyte,Incyte,Janssen,Novartis和Falk博士担任咨询委员会;并获得了布里斯托尔(Bristol-Myers)squibb,诺华,楚加(Chugai),伊光(Illumina)和福克(Falk)博士的赠款。 Schirmacher博士宣布没有利益冲突。Siebenhüner博士没有竞争利益;他曾在咨询委员会任职,并获得了Amgen,Bayer,Bristol-Myers Squibb,Ipsen,Lilly,Lilly,Merck,Pfizer,Sanofi,Sanofi和Servier的咨询酬金,并获得了本研究以外的工作。Mertens博士从Bristol-Myers Squibb,Bayer,Eisai,Gilead,Incyte,Intercept,Ipsen,Ipsen,MSD,Roche,Sanofi和Sigmatau担任咨询咨询奖。曾是Janssen,Incyte,Roche,Astrazeneca的发言人局成员;曾在Bristol-Myers Squibb,MSD,Amgen,Roche,Roche,Astrazeneca,Incyte,Incyte,Janssen,Novartis和Falk博士担任咨询委员会;并获得了布里斯托尔(Bristol-Myers)squibb,诺华,楚加(Chugai),伊光(Illumina)和福克(Falk)博士的赠款。Schirmacher博士宣布没有利益冲突。
AFH: Consulting or advisory roles (Bristol-Myers Squibb, Seattle Genetics, Merck, Genentech, Inc./ F. Hoffmann-La Roche Ltd, AstraZeneca/Medimmune, ADC Therapeutics, Takeda, AstraZeneca/Medimmune, Karyopharm, ADC, Regeneron, Genmab, Tubulis GmbH, Pfizer, Adicet Bio,Caribou Biosciences,Abbvie);旅行,住宿,费用(Bristol-Myers Squibb);研究资金(Bristol-Myers Squibb,Merck,Genentech,Inc./f。Hoffmann-La Roche AG,风筝,Gilead Company,Astrazeneca,Seattle Genetics,Gilead Sciences,ADC); ST:就业(Genentech,Inc。);领导力(F. Hoffmann-La Roche); LHS: Consulting or advisory role (Celgene, AbbVie, Seattle Genetics, TG Therapeutics, Janssen, Amgen, F. Hoffmann-La Roche/Genentech, Inc., Gilead Sciences, Lundbeck, Amgen, Apobiologix, Karyopharm Therapeutics, Kite, a Gilead Company, Merck, Takeda, Teva, TG Therapeutics,阿斯利康(Astrazeneca),Acerta Pharma,Morphosys,Incyte,Debiopharm群,Sandoz-Novartis,Genmab,Verastem); Honoraria(Amgen,Apobiologix,Abbvie,Celgene,Gilead Sciences,Janssen-Ortho,Karyopharm Therapeutics,Lundbeck,Merck,F。Hoffmann-La Roche La Roche Ltd/Genentech Ltd/Genentech Ltd/Genentech,Inc. Debiopharm群,Sandoz-Novartis,Verastem,Genmab);研究资金(F. Hoffmann- La Roche Ltd/Genentech,Inc。,Teva); FJ:咨询或咨询角色(F. Hoffmann-La Roche Ltd); Honoraria(F. Hoffmann-La Roche Ltd,Celgene,Janssen,Abbvie/Genentech,Inc。); GL:咨询或咨询角色(Genentech,Inc./f。Hoffmann-La Roche Ltd, Janssen-Cilag, Bristol-Myers Squibb, Novartis, MorphoSys, AstraZeneca, Gilead Sciences, Genmab/Seattle Genetics, Incyte, ADC Therapeutics, AbbVie, Genase, Immagene, Hexal, Lilly, Sobi, PentixaPharm, Miltenyi Biomedicine, Karyopharm Therapeutics);旅行,住宿,费用(Janssen-Cilag,Genentech,Inc./f。Hoffmann-La Roche Ltd,Abbvie,Gilead Sciences);专家证词(F. Hoffmann-La Roche Ltd); Honoraria(Janssen-Cilag,F。Hoffmann-La Roche Ltd/Genentech,Inc。),Astrazeneca,Bristol-Myers-Myers Squibb,Gilead Sciences,Novartis,Abbvie,Genmab/Genmab/Seattle Genetics,Constellation Genetics,Constellation Pharmaceuticals,adc Therapeuticals,adc Therapeutics,Incyte,Incyte,Sobi),Sobi);研究资金(Janssen-Cilag,F。Hoffmann-La Roche Ltd/Genentech,Inc。,Astrazeneca,Aquinox,Aquinox,Aquinox,Bayer,Gilead Sciences,Morphosys,Morphosys,Verastem,Verastem,Agios); MT:咨询或咨询角色(Takeda,Bristol-Myers Squibb,Incyte,Abbvie,Amgn,F。Hoffmann-La Roche Ltd,Gilead Sciences,Janssen,Morphosys,Morphosys,Novartis);旅行,住宿,费用(Gilead Sciences,Takeda,Bristol-Myers Squibb,F。Hoffmann-La Roche Ltd,Janssen,Abbvie); Honoraria(Janssen,Gilead Sciences,Takeda,Bristol-Myers Squibb,Amgen,Abbvie,F。Hoffmann-La Roche Ltd,Morphosys,Morphosys,Novartis); GS:咨询或咨询角色
mo:Merck,MSD,Transgene,Roche,Abbvie,Ayala Pharmaceuticals,Alx肿瘤学,Debiopharm International,Isa Pharmaceuticals,Boehringer Ingelheim,Seagen,Gilead,Gilead和BMS; LG:阿斯利康,Boehringer Ingelheim,Roche,Bristol Myers Squibb,MSD,Takeda,Abbvie,Novartis和Pfizer; MP-S:Incyte,Genentech,F。Hoffmann-La Roche Ltd,TFS HealthScience,Astrazeneca和BMS; VM:Bayer,Basilea Pharmaceutica,Bristol Myers Squibb,Janssen和Pieris; HP:Amgen,Roche,Sanofi,Astrazeneca和Bayer; DW:Boehringer Ingelheim,Novartis,Pfizer,AOP,Roche,Bristol Myers Squibb,Merck&Co。,Celgene和Gilead; A-MQ,SL和VH:Boehringer Ingelheim的员工; MP:Boehringer Ingelheim,Astrazeneca,Eli Lilly,Astellas和Sanofi Aventis。可以在电子寄养者上找到完整的作者披露。
S. Vermeire received grants from AbbVie, Johnson & Johnson, Pfizer, Galapagos, and Takeda and has received consulting and/or speaking fees from AbbVie, AbolerIS Pharma, Agomab, Alimentiv, Arena Pharmaceuticals, AstraZeneca, Avaxia, BMS, Boehringer Ingelheim, Celgene, CVasThera, Dr Falk Pharma, Ferring, Galapagos, Genentech-Roche, Gilead, GSK, Hospira, IMIDomics, Janssen, Johnson & Johnson, Lilly, Materia Prima, MiroBio, Morphic, MRM Health, Mundipharma, MSD, Pfizer, ProDigest, Progenity, Prometheus, Robarts Clinical Trials, Second Genome, Shire, Surrozen, Takeda, Theravance,Tillotts Pharma Ag和Zealand Pharma。A. Yarur从Takeda,Prometheus Labs,Arena Pharmaceuticals和Bristol Myers Squibb和Bristol Myers Squibb的发言人费用获得了咨询费。D.T.鲁宾已获得武田的赠款支持; has served as a consultant for AbbVie, Abgenomics, Allergan, Boehringer Ingelheim, Bristol Myers Squibb, Celgene Corp/Syneos, Dizal Pharmaceuticals, GalenPharma/Atlantica, Genentech/Roche, Gilead Sciences, Ichnos Sciences S.A., GSK Services, Janssen, Eli Lilly, Pfizer, Prometheus实验室,Reistone,Shire,Takeda和TechLab。M.C. 杜宾斯基收到了Abbvie,Arena,Bristol Myers Squibb,Celgene,Eli Lilly,Genentech,Gilead,Gilead,Janssen,Janssen,Prometheus Labs和Takeda的咨询费,并且是Trellus Health的创始人和股东。 M. regueiro已收到M.C.杜宾斯基收到了Abbvie,Arena,Bristol Myers Squibb,Celgene,Eli Lilly,Genentech,Gilead,Gilead,Janssen,Janssen,Prometheus Labs和Takeda的咨询费,并且是Trellus Health的创始人和股东。M. regueiro已收到