营业费用总额 114,481 136,801 86,524 营业亏损 (68,608) (105,672) (65,327) 其他费用净额: 利息费用 (17,570) (6,893) (8,342) 其他收入(费用)净额 1,155 (1,259) (5,415) 其他费用总额净额 (16,415) (8,152) (13,757) 所得税准备金前亏损 (85,023) (113,824) (79,084) 所得税准备金 3,914 2,889 456 净亏损 (88,937) (116,713) (79,540)
改变生活的肠癌治疗方法被加入 PBS,惠及数千名澳大利亚人 澳大利亚皇家病理学院 (RCPA) 支持今年将针对转移性结直肠癌 (mCRC) 的靶向治疗药物 Braftovi 添加到药品福利计划 (PBS) 中,此举将改善澳大利亚数千名患者的健康状况。RCPA 研究员 Anthony Gill 教授解释说,将 Braftovi 添加到 PBS 是一个令人鼓舞的进步,将显著改善患者的健康状况。“与 PBS 列出的抗癌药物西妥昔单抗联合使用,Braftovi 有可能减缓或阻止癌症的生长,并可以帮助一些晚期 mCRC 患者延长生存期并提高生活质量。将 Braftovi 添加到 PBS 中极大地改善了患者的使用机会,这意味着现在每个疗程的费用为 42.50 澳元或 6.80 澳元(优惠卡持卡人)而不是像以前那样每个疗程 33,600 澳元,”吉尔教授说。为了确定是否有资格通过 PBS 使用 Braftovi,患者必须首先进行癌症检测,以检查 RAS 基因(KRAS 和 NRAS)和 BRAF 基因是否存在突变。在 RCPA 向医疗服务咨询委员会 (MSAC) 提出申请后,此项检测现已在医疗保险福利计划 (MBS) 上为 mCRC 患者提供。“多年来,mCRC 患者一直有资格通过 MBS 使用一种名为西妥昔单抗的药物,但前提是他们的肿瘤没有 KRAS 或 NRAS 基因突变。这是因为我们知道西妥昔单抗对具有这些突变的肿瘤不起作用。我们目前所知的是,肿瘤中存在 BRAF 突变的 mCRC 患者对西妥昔单抗的反应不佳,即使他们没有 RAS 突变。然而,我们现在知道,当西妥昔单抗与 Braftovi(一种 BRAF 抑制剂)联合使用时,这些患者会对西妥昔单抗有反应。 “为了获得这种治疗,患者必须对其结肠癌进行 RAS 和 BRAF 突变检测。PBS 已经为 mCRC 的 RAS 突变检测提供资助,但现在这项资助已扩大到包括增加 BRAF 突变检测,大大提高了有需要的人的可及性。 “这又是一个例子,说明准确且易于获取的病理学检测如何指导如此多疾病的治疗。它不仅能让我们在正确的时间为正确的患者提供正确的治疗,同样重要的是,它还能让我们建议患者不要使用对他们无效的疗法来治疗他们。例如,我们知道,如果肿瘤有 RAS 突变或缺乏 BRAF 突变,这种治疗将不会有帮助,”吉尔教授说。自 20 世纪 90 年代中期以来,50 岁以下人群中新的转移性结直肠癌病例数量一直在增加。现在,mCRC 是最致命的癌症,也是 25-44 岁澳大利亚人死亡的第五大原因。每年有超过 15,000 名澳大利亚人被诊断出患有 CRC,而且这一数字还在不断上升。BRAF 基因突变使 mCRC 更具侵袭性,对化疗更具抵抗力,这些患者的治疗选择极其有限。这种突变影响了大约十分之一的澳大利亚晚期 mCRC 患者,导致预后不良,平均存活时间为
Figure 9: Annual Model Employment Change by Industry and Scenario (Thousands of Jobs) ....................................................................................................................................................... 24
• Headquartered in Columbus, Ohio, with additional sales, management, and manufacturing operations in Portland, Oregon, and Waalwijk, The Netherlands • Product installations in over 70 countries and thousands of healthcare facilities worldwide • Our comprehensive product suite ensures medication administration accuracy and control from the pharmacy to the patient, and greatly improves the efficiency of the nursing staff
Block 1: Understanding Grifols We address the needs of thousands of patients..................................................... 12 Joining forces with Biotest.................................................................................... 13 Our global footprint.............................................................................................. 14 Our business model creates value......................................................................... 16 Sustainability and human rights.............................................................................18 Grifols' value chain............................................................................................... 36 Donors and patients............................................................................................. 52 Innovation at Grifols............................................................................................. 72
• Bluff is a multi-player card game in which each player tries to empty their hand first • Build four different agents to play Bluff and find out how they perform over thousands of games • Create two AI computer players having offensive strategy and two others with defensive strategy • Evaluate performance on various scenarios based on experiments such as Self play and Evolutionarily stable strategy • Develop variants of the agents – ‘mutants' to see how they perform against better players
• Supports one-time pad, symmetric key and asymmetric key ciphers, key derivation, random objects, certification and some cryptographic operations • Support for Bring Your Own Key (BYOK) operations with AWS and MS Azure • Encrypted keystore with protected root of trust • Granular, hierarchical and auditable access control • Event log, audit log, date and time of transaction, management and user reports • Thousands of每个节点的端客户系统,每个节点的8,000个关键请求/分钟•参加或无人看管的安全启动
行政教育对于建立一种促进新技术和解决方案的文化并建立了一支劳动力的文化至关重要,该文化与对技术,商业和监管景观的快速转变需求保持一致。致力于使所有人都可以接受优质教育的原因,IIT Delhi已在Evidya@iitd(IITD(IITD)下启动了在线证书计划:启用虚拟和互动性学习,以推动印度和国际参与者的ITD@iitd@iitd@iitd@iitd。These outreach programmes offered by the Indian Institute of Technology Delhi (IIT Delhi) are designed to cater to the training and development needs of various organizations, industries, society and individual participants at national and international level with a vision to empower thousands of young learners by imparting high-quality Online Certificate Programmes in cutting- edge areas for their career advancement in different domains of engineering, technology, science, humanities and management.有关更多详细信息,请访问:http://cepqip.iitd.ac.in
Production Capacity and Utilization FY23A FY24A Installed Capacity - Blades in Units (mln) 2,230.00 2,230.00 Actual Production - Blades in Units (mln) 1,705.00 1,516.00 Utilization (%) 76.46% 67.98% Installed Capacity - Batteries in Numbers in Thousands 1,200.00 1,200.00 Actual Production - Batteries in数千733.16 646.26利用率(%)61.11%53.85%安装能力 - 成千上万的会话中的血液透析集中2,400.00 2,400.00实际产量 - 实际产量 - 成千上万次的血液透析集中度2,473.00 2,358.00 corrigation(5,358.00 corrivient)(5,358.00 uigivie)uligation(5,255.25%)10.25.04%104%5.04%104%104%4%。箱子MT 30,000.00 30,000.00实际生产 - 瓦楞纸盒MT 20,466.00 18,028.00用途(%)68.22%60.09%的安装能力 - 单位的自行车18,000.00 18,000.00实际生产 - 实际生产 - 自行车470.00 175.00利用率(%)2.9.9.97%0.97%
加利福尼亚州食品和农业部(CDFA)动物健康和食品安全服务部(AHFSS)和加利福尼亚动物健康与食品安全实验室系统(CAHFS)是预防,检测和对动物健康疾病暴发的反应的合作伙伴。大会第2772号法案(第1536章,1982年的法规)要求CDFA秘书与加利福尼亚大学(UC)摄政委员会和UC戴维斯大学兽医学院签约,以建立和运营家禽和牲畜疾病诊断实验室,以进行指导测试和检查和检查和诊断,并诊断Livestock and livestock and Pultry and and and livest canceasece and Poultry anceasecess和Poultry canceas and and and and and and cant and canceasecease and Poultry ancease and Poultry anceasece。CAHFS is funded as a line-item in the CDFA budget and operates a network of four veterinary diagnostic laboratories to provide statewide testing services for disease surveillance to thousands of animal-producing farms, hobby, and backyard animal owners throughout California for high-consequence diseases such as Avian Influenza, Foot and Mouth Disease, and Virulent Newcastle Disease, as well as food safety testing, including milk和乳制品测试。