ndia's food security story is at a critical juncture. With a burgeoning popula- tion projected to reach 150 crore by 2030-32, the demand for food grains is estimated to reach a staggering 350 million tonnes. This burgeoning demand coincides with a period of environmental challenges: depleting natural resources and the ever-present threat of climate change. In this complex scenario, agricul- tural Research and Development (R&D) emerges as the cornerstone of securing agricultural productivity and environmental sustainability. With the global population continuing to expand and rising temperatures placing strain on farming resources, the agricultural sector faces an uphill battle. Agricultural companies must harness the power of R&D to fortify the sector against these challeng- es through continuous resource enhance- ments and production improvements. The overarching strategy to meet escalating demand revolves around enhancing pro- ductivity while simultaneously increasing the income of farmers.
>s lurncnt,I lnlroJut。:tion,剪切力和D�1h.l i ng剪切力和弯矩的微分方程,静定梁的剪切力和弯矩图。桁架:介绍,简单桁架和简单桁架的解决方案,截面法;接头法;如何确定构件是处于拉伸还是压缩状态;简单桁架;零力构件质心和惯性矩:介绍,平面,曲线,面积,体积和复合体的质心,平面面积的惯性矩,平行轴定理和垂直轴定理,复合体的惯性矩。运动学和动力学:线性运动、瞬时中心、达朗贝尔原理、刚体旋转、冲量和动量原理、功和能量原理。简单应力和应变:应力的定义、应力张量、轴向载荷构件的法向应力和剪应力、应力-应变关系、延性和脆性材料单轴载荷的应力-应变图、胡克定律、泊松比、剪应力、剪应变、刚度模量、弹性常数之间的关系。不同横截面构件的一维载荷、温度应力、应变能。
(e)“已知的地热资源领域”是指在秘书看来,地质,附近的发现,竞争利益或其他迹象将使人们对在主题中经历过的男人的信念,即在主题中经历过的男人,即在地理热蒸汽或相关的地热资源中的出现前景,足以为这一目的提供足够的费用。sec。3。Subject to the {provisions of section 15 of this Act, the Secre- tary of the Interior may issue leases for the development and utiliza- tion of geothermal steam and associated geothermal resources (1) in lands administered by him, including public, withdrawn, and acquired lands, (2) in any national forest or other lands administered by the Department of Agi-iculture through the Forest Service, including pub- lic, withdrawn,并收购了土地,(3)在美国所传达的土地上,但要保留向美国的地热蒸汽和相关的地热资源保留。
idiv是DFG的研究中心。idiv是莱比锡大学的中心设施,萨克森州的高等教育学术自由法第92(1)条(“sächsischeshochschulfreiheitsgesetzetz,sächshsfg”)。它与马丁·路德大学哈雷·韦特伯格和弗里德里希·席勒大学耶拿以及与赫尔姆霍尔茨环境研究中心合作 - UFZ一起运行。The following non-university research institutions are involved as coopera- tion partners: the Helmholtz Centre for Environmental Research (UFZ), the Max Planck Institute for Biogeochemistry (MPI BGC), the Max Planck Institute for Chemical Ecology (MPI CE), the Max Planck Institute for Evolutionary Anthropology (MPI EVA), the Leibniz Institute DSMZ - german微生物和细胞培养物,莱布尼兹植物生物化学研究所(IPB),莱布尼兹植物遗传学与作物植物研究所(IPK)和莱布尼兹学院Senckenberg自然历史博物馆Görlitz(SMNG)。
治疗方法,现有疗法主要依赖于运动和饮食控制。因此,迫切需要对该疾病的新药或治疗靶标。葡萄糖共转运蛋白2(SGLT2)是葡萄糖共转运蛋白家族之一。它主要存在于肾脏的肾近端小管中,并介导葡萄糖的重吸收。The represen- tative drug of SGLT2 inhibitors (SGLT2i) is dapagliflozin, a new class of hypoglycaemic drug, which has an ac- tion mechanism that reduces blood glucose by inhibiting the reabsorption of glucose by the proximal convoluted tubules of the kidney, thus allowing excess glucose to be excreted from urine.研究表明,SGLT2I不仅降低了血糖,而且对肝功能具有保护作用[6]。但是,具体机制尚未确定。NAFLD的发病机理很复杂,但主要集中于胰岛素抵抗和炎症,血液中肝酶的变化是确定
摘要:为了提高3D过渡金属复合物中M @ L键的理解,可以通过能量分解分析分析化学价模型(EDA-NOCV)的天然轨道,因为它提供了对M @ L Incractions的完整,定量和化学直觉的缩写描述。在这项研究中,由于过渡温度(T 1/2)对M @ l键的微妙变化而言,通过使用八面体自旋(SCO)配合物来建立并验证了通常适用的碎片和计算方案。Specifically, EDA-NOCV analysis of Fe @ N bonds in five [Fe II ( L azine ) 2 (NCBH 3 ) 2 ], in both low-spin (LS) and paramagnetic high-spin (HS) states led to: 1) development of a general, widely applicable, corrected M + L 6 fragmenta- tion, tested against a family of five LS [Fe II ( L azine ) 3 ](BF 4 ) 2复合物;这证实了三个L苯二氮更强
He has been ranked 1 among the top 100 individual researchers across the world who had published research articles in the International Journal of Production Researc h (1985-2010), the top leading author for Supply Chain Analytical Techniques (Comput er & Industri al Engineering ), amo ng T op 20 mo st producti ve autho rs in t he ar ea of Production and Operations Management in the last 50 years (Int.Journal of Produc tion Econom ics, 2 009) and r ated 2nd a mong many researc hers wor kin g in Logis tic s and S upply Chain Manag eme nt in India (Ana lys is o f the logi stics Res ear ch in India -White paper published in TU Dortmund University, Dortmund Germany-2012).
摘要:快速,定期监测和评估区域生物多样性是生物多样性研究和保护的重要意义。近年来,遥感技术已广泛应用于生物多样性研究中,并可以提供区域,大陆和全球生物多样性信息。这种方法是低成本和高数据一致性,并且很大程度上更新了。This paper introduced the principles and advantages of remote sensing in biodiversity re鄄 search, and summarized the main application aspects of biodiversity remote sensing in practice, including landscape indices, NDVI, spectral variation hypothesis (SVH), and hyperspectral re鄄 mote sensing, with the focus on the analysis of the advantages and disadvantages of these applica鄄 tion aspects and the recent research SVH研究和最佳频段选择的进步。指出了遥感生物多样性研究中的缺陷,并且研究了该研究领域的发展趋势,例如模型,遥感者和规模效应。
未来的设计工具将由人工智能驱动,这些矛盾需要得到解决。因此,我们需要考虑人工智能如何融入支持知识工作的设计工具(即旨在支持用户创作过程的设计工具),以及人工智能如何激励设计师为用户创造新体验,而不会削弱人们对人工智能驱动系统的信任。虽然之前关于人工智能在用户体验(UX)工具中的作用的研究有些有限,但我们可以从关于人工智能在其他创意环境中的作用的研究中汲取教训。例如,对艺术家与人工智能绘图工具合作的研究表明,创意人员更喜欢一定程度的自主权,并希望“检查”人工智能创作的作品[4]。另一项研究发现,人工智能可以作为新艺术体验的灵感来源。研究人员创建了一个深度神经网络,学会了将艺术风格转移到其他图像上,例如,2016 年开发的一项算法探索将文森特·梵高的《星夜》的风格转移到了一幅鸭子画上。反过来,这种探索又引发了一系列视觉艺术和视频领域的艺术探索 [1]。同样,研究人员训练人工智能模型,使其发挥更客观的“第三只眼睛”的作用,帮助艺术史学家自信地识别和解释艺术作品 [6]。对于创意写作等更复杂的创作过程,辅助创意写作过程的工具已经利用众包工作者作为“自动化器”来产生故事创意,帮助作家畅所欲言 [3]。同样,一个面向视觉艺术家的人工智能绘图工具发现,艺术家愿意将某些琐碎的任务委托给人工智能,但不太愿意让人工智能“驱动”创作过程 [4]。虽然这些现有的作品是人工智能驱动的系统或创意写作方面的准系统如何补充现有创作实践的例子,但用户体验设计师如何看待旨在支持其创作过程的人工智能驱动工具仍不得而知。随着我们越来越多地了解将自动化引入设计过程的机会,我们已经开始发现人工智能对设计师有帮助的用例。我们将自己定位为人工智能的倡导者,通过自动化繁琐的任务和/或作为用户创作过程的助手提供灵感来支持设计师。我们的研究结果支持这一观点,即自动化必须向用户解释;即设计师应该能够发现哪些操作会影响设计工具中人工智能驱动的体验,并且应该能够审查人工智能系统产生的工作[5]。虽然这些想法正在兴起,但人们对人工智能的信任这一一般概念已被探索为用户接受人工智能驱动系统的关键[2]。
The quest for targeted therapies is critical in the battle against cancer. The RAS/ MAP kinase pathway is frequently implicated in neoplasia, with ERK playing a crucial role as the most distal kinase in the RAS signaling cascade. Our previous research demonstrated that the interaction between ERK and MYD88, an adaptor protein in innate immunity, is crucial for RAS-dependent transforma- tion and cancer cell survival. In this study, we examine the biological con- sequences of disrupting the ERK-MYD88 interaction through the ERK D-recruitment site (DRS), while preserving ERK ' s kinase activity. Our results indicate that EI-52, a small-molecule benzimidazole targeting ERK-MYD88 interaction induces an HRI-mediated integrated stress response (ISR), resulting in immunogenic apoptosis speci fi c to cancer cells. Additionally, EI-52 exhibits anti-tumor ef fi cacy in patient-derived tumors and induces an anti-tumor T cell response in mice in vivo. These fi ndings suggest that inhibiting the ERK-MYD88 interaction may be a promising therapeutic approach in cancer treatment.