In the intensive care unit (ICU), unresponsive patients with acute brain injury may retain a higher level of consciousness than apparent at the bedside. Our study highlights the utility of functional near - infrared spectroscopy (fNIRS), a portable optical neuroimaging device, for detecting the neural signatures of conscious processing. We identified resting - state networks, sensorimotor and auditory processing, and command - driven brain activity at the individual level in healthy participants. Moreover, we applied fNIRS to detect preserved consciousness in three severely brain - injured ICU patients and found that one patient had fully preserved awareness despite lacking behavioral signs of consciousness. Our study highlights the potential of fNIRS as a valuable tool for identifying hidden cognitive states in patients following serious brain injury.
• Telecoms providers have been working on upgrading the UK's national network to a digital Internet Protocol (IP) network • In an emergency 1 in 10 calls from analogue telecare equipment will be impacted by the digital upgrade of the UK's telecoms network • The impact at worst will result in multiple reattempts to connect costing valuable minutes in an emergency, at best it could be distortion • Appello DigitalBridge is an intelligent conversion solution that takes an analogue communication从现场设备将其转换为数字通信协议,并以他们理解的语言将其转移回数字监控中心。•上诉数字桥可以将一系列不同的模拟协议转换为几种不同的输出数字协议•由于它是基于云的解决方案,因此不需要在现场安装任何设备及其完全可扩展的设备。
一些人超越了协助研究的正常职责召唤。Gina Ziervogel博士在2006年11月30日至12月1日参加了Biofuels Markets Africa会议,代表作者参加了来自南部非洲的主要行业利益相关者,并随后与主要利益相关者进行了联络。John博士以前的Grainsa和Biofuels任务团队进行了电话采访和关键见解。Jose Domingos Gonzalez Miguez, Executive Secretary of Ministry of Science and Technology, Brazil (formerly of Petrobras) gave an interview while he was in Oxford in which he shared valuable information on the emergence of the Brazil bioethanol industry, Mr S Tyatya, Chief Director Clean Energy and Energy Planning Department of Minerals and Energy provides comments from the perspective of South African Government.
Valuable Comments and Inputs Were Provided by Iea ColleAgues (in Alphabetical Order): Ashley Acker, Piotr Bojek, Stéphanie Bouckaert, Francois Briens, Eren Cam, Jonathan Coppel, Javier Jorquera Copier, Marc Casanovas, Tanguy de Bienassis, Chiara Delmab. Dirtil,Keith Everhart,Eric Fabozzi,Paolo Frankl,Enrique Gutierrez-Tavarez,Julia Guyon,Pablo Hevia-Koch,Zoe Hungerford,Nick Johnstone,Rena Kuwahata,Silvia Laera,Silvia Laera,Rebecca McKimm,Rebecca McKimm,Aloys nghiem,Aloys nghiem,alsesio isaia petrica isaia petrich,葡萄牙,Alison Pridmore,Arnaud Rouget,Alexandre Roussel,Gianluca Tonolo,Kartik Veerakumar,Brent Wanner,Jacques Warichet以及前IEA分析师Luis Lopez。 这项工作得益于顾问Matt Chester,Peter Fraser,Astha Gupta,Luis Munuera,Helena Lindquist,Helena Lindquist,Alvaro Lopez-Peña和Monica Trolo的专业知识。Valuable Comments and Inputs Were Provided by Iea ColleAgues (in Alphabetical Order): Ashley Acker, Piotr Bojek, Stéphanie Bouckaert, Francois Briens, Eren Cam, Jonathan Coppel, Javier Jorquera Copier, Marc Casanovas, Tanguy de Bienassis, Chiara Delmab. Dirtil,Keith Everhart,Eric Fabozzi,Paolo Frankl,Enrique Gutierrez-Tavarez,Julia Guyon,Pablo Hevia-Koch,Zoe Hungerford,Nick Johnstone,Rena Kuwahata,Silvia Laera,Silvia Laera,Rebecca McKimm,Rebecca McKimm,Aloys nghiem,Aloys nghiem,alsesio isaia petrica isaia petrich,葡萄牙,Alison Pridmore,Arnaud Rouget,Alexandre Roussel,Gianluca Tonolo,Kartik Veerakumar,Brent Wanner,Jacques Warichet以及前IEA分析师Luis Lopez。这项工作得益于顾问Matt Chester,Peter Fraser,Astha Gupta,Luis Munuera,Helena Lindquist,Helena Lindquist,Alvaro Lopez-Peña和Monica Trolo的专业知识。
Chad Kendall: chadkend@marshall.usc.edu Ryan Oprea: roprea@gmail.com We thank Guillaume Frechette, Cary Frydman, Thomas Graeber, Ariel Rubinstein, Andrew Schotter, Emanuel Vespa, Georg Weizsacker, and Sevgi Yuksel for valuable conversations about this research.我们感谢纽约大学,伯克利·哈斯(Berkeley Haas),耶鲁大学,斯坦福大学,斯坦福大学,萨里,皇后区,柏林行为经济学研讨会,德克萨斯理工大学,第六届世界游戏理论协会的第六届世界大会,在揭露的偏好(WARP)和USC上的研讨会和USC。这项研究得到了国家科学基金会的支持,该基金会在Grant SES-1949366的支持下得到了UC Santa Barbara IRB的批准。1我们指的是“心理模型”(而不是“模型”),以强调他们不需要正式,明确甚至有意识地向决策者(DMS)提供,以指导选择。
My managers at Saab, Ulrik Pettersson and Henrik Pettersson; you gave me important sup- port and found time when I needed it. A special thank goes to Sören Steinkellner who in- spired me and often took me down from the ‘abstract heights’. At Saab, there are many col- leagues and co-authors that I want to thank; Ingela Lind, Magnus Carlsson, and many more. Thanks also to Lars Karlsson, Magnus Jomander, Kristoffer Johansson, Robert Lindohf and all of you in the EMMA team and at the Saab Simulator-Center who provided me with chal- lenges, knowledge, and data for this research. I also wish to thank members of the Machine Design and Fluid and Mechatronic Systems divisions for your friendship and valuable feed- back. I am also grateful to the ProViking research school and all inspiring PhD students.
The authors would like to thank all the participants of the interviews and those who contributed with data and case studies for their valuable input: Abdullah Alkulaib, Adam Ostaszewski, Alexandre Boon, Amadou Diallo, Carol Mungo, Charlie Knight, David Knaute, Diana Benato, Denis Muhoza, Ethiopia Haileyesus Yema, Goehringer Veit, Hamadou Tchiemogo, Jaivardhan Singh, Javier Mazorra, Jean Damascene Hategekimana, Joanis Holzigel, Jupsergi Prodige Dimi Ngolo, Kamran Siddiqui, Klaus Strasser, Louis Tavernier, Martha Mulerwa, Maria Knodt, Marina Madeo, Mbaitadom Mbaitenbe, Nour Alnajjar, Paul Yillia, Rainatou Co ulibaly, Rakesh Gupta, Nichanametla Ramasubbaiah, Ranjit Dhiman, Saddam Mohammed Zodi, Salvatore Vinci, Sikha VS, Simrin Chhachhi, Sonia Ramos, Spyridon Charamis, Surabhi Rajagopal, Teresa Le, Yuhei Honda, Yuri Lima Handem
95 Online Systems Software 195844 Individual AI Yoga Guru Saanvi Tayal Rahul Public School Delhi New Delhi 96 Online Systems Software 196523 Individual Valuable Trash Pranet Hiranandani The Cathedral and John Connon School Maharashtra Mumbai 97 Online Systems Software 197246 Individual Parkinson Disease Detection Using Markerless Video Arav Dhoot Neerja Modi School拉贾斯坦斋浦尔98在线翻译医学科学196411团队洞察力Arya Neel Aryel Arjun Raks Raks Pallikooodam Tamil Nadu Coimbatore 99在线转化医学科学196372个体视野内部的游戏研究阿尔茨海默氏症的评分算法Prisha Goyal Scope公立学校Madhya Bhopal 101在线转化医学科学196966 Team Parkinstep:电子监视器 - 揭幕帕金森氏症的步态
NSP3(NSP3MD)的大域在甲虫病毒中高度保守,而Chikungunya病毒(CHIKV)NSP3MD的ADP-核糖基水合酶活性对于Chikv病毒复制和毒力至关重要。迄今已确定针对CHIKV NSP3的小分子药物。在这里,我们报告了与NSP3MD结合的小片段,这些片段实际上是通过筛选片段和X射线晶体学来解决的。这些鉴定出的片段具有相似的支架,2-吡啶酮-4-羧酸,并特别结合了NSP3MD的ADP-核糖结合位点。Among the fragments, 2-oxo-5,6-benzo- pyrimidine-4-carboxylic acid showed anti-CHIKV activity with an IC 50 of 23 μ M. Our frag- ment-based drug discovery approach provides valuable information to further develop a specific and potent nsP3 inhibitor of CHIKV viral replication based on the 2-pyrimidone-4- carboxylic acid scaffold.表明,这种嘧啶支架也可以与其他α病毒和冠状病毒的大域结合,因此具有潜在的抗病毒活性。
WBGU要感谢所有外部专家的投入和宝贵的帮助。As a technical introduction to the topic, the WBGU received valuable input at expert hearings on 9 and 10 May 2023 with Prof Dr Akiça Bahri (former Minister of Agriculture, Tunisia), Prof Dr Christoph Donner (Ber- liner Wasserbetriebe) and Prof Dr Uli Paetzel (Deutsche Vereinigung für Wasserwirtschaft).2023年11月17日,约翰内斯·库尔曼(Johannes Cullmann)博士(联合国水)对WBGU对多边水政策进行了非常有趣的见解。During the expert hearing on 2 May 2024, the WBGU had the opportunity to exchange views with Prof Dr Dietrich Borchardt (Helmholtz Centre for Environmental Research – UFZ), Dr Ines Dombrowsky (German Institute of Development and Sustainability – IDOS), Prof Dr Dieter Gerten (Potsdam Institute for Climate Impact Research – PIK), Prof Dr Hans-Peter Grossart (Leibniz Institute of Freshwater生态学和内陆渔业),VerenaHöckele博士(ProjekträgerKarls-ruhe/Wassertechnologie,KarlsruherInstitutfürTechnologie - kit)弗莱堡)。