Jens Luebeck。AmpliconSuite:分析癌症基因组中的局部扩增 Anderson Bussing。FAST-scDECO:一种灵活、自适应的可扩展单细胞差异共表达分析工具 Ha Nguyen。DSCC:使用共识网络和多组学数据整合进行疾病亚型分析 Farzan Taj。一种用于预测单个癌细胞对遗传和化学扰动的反应的深度学习基础模型 Alexander Wenzel。数据驱动的基因特征细化用于富集分析和细胞状态表征 Daniel Bergman。轻松将多组学分析集成到基于代理的模型中:PhysiCell 的生物信息学演练 Sriya Potluri。ImmunoPheno:一个用于设计和分析免疫表型实验的数据驱动生物信息学平台 Selina Wu。通过分期改善肿瘤亚克隆重建:遗传性平滑肌瘤病和肾细胞癌病例研究 Jaime Wehr。精准肿瘤学决策支持信息学方法将可操作基因型与靶向疗法相匹配 Tushar Mandloi。CancerModels.Org - 一个开放的全球癌症研究平台,用于患者衍生的癌症模型。快闪演讲 5 月 16 日
Karim Lekadir, 1.2 Alejandro F Frangi, 3.4 Antonio R Porras, 5 Ben Glocker, 6 Celia Cintas, 7 Curtis P Langlotz, 8 Eva Weicken, 9 Folkert W Athsselbergs, 10.11 Fred Prior, 12 Gary S Collins, 13 Georgios Kaissis, 14 Gianna Tsakou, 15 Irène Bvat, 16 Jayashere Kalpathy-Cramer,17 John Mongan,18 Julia in Schnabel,19 Kaisar Kushibar,1 Katrine Riklund,20 Kostas Marias,21 Lameck M Amugongo,22 Lauren A Fromont,Fromont,23 Lena Maier-Hein,23 Lena Maier-Hein,24 LeonorCerdá-Alberich,25 luishirious,25 luiismartí,25 luiismartí-batifi。 Jorge Cardoso, 27 Maciej Bobowicz, 28 Mahsa Shabani, 29 Manolis Tsiknakis, 21 Maria in Zuluaga, 30 Marie-Christine Fritzsche, 31 Marina Camacho, 1 Marius George Linguraru, 32 Markus Wenzel, 9 Marleen de Bruijne, 33 Martin G Tolsgaard, 34 Melanie Goisauf, 35 Mónica Cano Abadía, 35 Nikolaos Papanikolaou, 36 Noussair Lazrak, 1 Orol Pujol, 1 Richard Osuala, 1 Sandy Napel, 37 Sara Colantonio, 38 Smriti Joshi, 1 Stefan Klein, 33 Susanna Aussó, 39 Wendy a Rogers, 40 Zohaib Salahuddin,41 Martijn P A Starmans 33;代表未来的ai联盟Karim Lekadir, 1.2 Alejandro F Frangi, 3.4 Antonio R Porras, 5 Ben Glocker, 6 Celia Cintas, 7 Curtis P Langlotz, 8 Eva Weicken, 9 Folkert W Athsselbergs, 10.11 Fred Prior, 12 Gary S Collins, 13 Georgios Kaissis, 14 Gianna Tsakou, 15 Irène Bvat, 16 Jayashere Kalpathy-Cramer,17 John Mongan,18 Julia in Schnabel,19 Kaisar Kushibar,1 Katrine Riklund,20 Kostas Marias,21 Lameck M Amugongo,22 Lauren A Fromont,Fromont,23 Lena Maier-Hein,23 Lena Maier-Hein,24 LeonorCerdá-Alberich,25 luishirious,25 luiismartí,25 luiismartí-batifi。 Jorge Cardoso, 27 Maciej Bobowicz, 28 Mahsa Shabani, 29 Manolis Tsiknakis, 21 Maria in Zuluaga, 30 Marie-Christine Fritzsche, 31 Marina Camacho, 1 Marius George Linguraru, 32 Markus Wenzel, 9 Marleen de Bruijne, 33 Martin G Tolsgaard, 34 Melanie Goisauf, 35 Mónica Cano Abadía, 35 Nikolaos Papanikolaou, 36 Noussair Lazrak, 1 Orol Pujol, 1 Richard Osuala, 1 Sandy Napel, 37 Sara Colantonio, 38 Smriti Joshi, 1 Stefan Klein, 33 Susanna Aussó, 39 Wendy a Rogers, 40 Zohaib Salahuddin,41 Martijn P A Starmans 33;代表未来的ai联盟
Karim Lekadir, 1.2 Alejandro F Frangi, 3.4 Antonio R Porras, 5 Ben Glocker, 6 Celia Cintas, 7 Curtis P Langlotz, 8 Eva Weicken, 9 Folkert W Athsselbergs, 10.11 Fred Prior, 12 Gary S Collins, 13 Georgios Kaissis, 14 Gianna Tsakou, 15 Irène Bvat, 16 Jayashere Kalpathy-Cramer,17 John Mongan,18 Julia in Schnabel,19 Kaisar Kushibar,1 Katrine Riklund,20 Kostas Marias,21 Lameck M Amugongo,22 Lauren A Fromont,Fromont,23 Lena Maier-Hein,23 Lena Maier-Hein,24 LeonorCerdá-Alberich,25 luishirious,25 luiismartí,25 luiismartí-batifi。 Jorge Cardoso, 27 Maciej Bobowicz, 28 Mahsa Shabani, 29 Manolis Tsiknakis, 21 Maria in Zuluaga, 30 Marie-Christine Fritzsche, 31 Marina Camacho, 1 Marius George Linguraru, 32 Markus Wenzel, 9 Marleen de Bruijne, 33 Martin G Tolsgaard, 34 Melanie Goisauf, 35 Mónica Cano Abadía, 35 Nikolaos Papanikolaou, 36 Noussair Lazrak, 1 Orol Pujol, 1 Richard Osuala, 1 Sandy Napel, 37 Sara Colantonio, 38 Smriti Joshi, 1 Stefan Klein, 33 Susanna Aussó, 39 Wendy a Rogers, 40 Zohaib Salahuddin,41 Martijn P A Starmans 33;代表未来的ai联盟Karim Lekadir, 1.2 Alejandro F Frangi, 3.4 Antonio R Porras, 5 Ben Glocker, 6 Celia Cintas, 7 Curtis P Langlotz, 8 Eva Weicken, 9 Folkert W Athsselbergs, 10.11 Fred Prior, 12 Gary S Collins, 13 Georgios Kaissis, 14 Gianna Tsakou, 15 Irène Bvat, 16 Jayashere Kalpathy-Cramer,17 John Mongan,18 Julia in Schnabel,19 Kaisar Kushibar,1 Katrine Riklund,20 Kostas Marias,21 Lameck M Amugongo,22 Lauren A Fromont,Fromont,23 Lena Maier-Hein,23 Lena Maier-Hein,24 LeonorCerdá-Alberich,25 luishirious,25 luiismartí,25 luiismartí-batifi。 Jorge Cardoso, 27 Maciej Bobowicz, 28 Mahsa Shabani, 29 Manolis Tsiknakis, 21 Maria in Zuluaga, 30 Marie-Christine Fritzsche, 31 Marina Camacho, 1 Marius George Linguraru, 32 Markus Wenzel, 9 Marleen de Bruijne, 33 Martin G Tolsgaard, 34 Melanie Goisauf, 35 Mónica Cano Abadía, 35 Nikolaos Papanikolaou, 36 Noussair Lazrak, 1 Orol Pujol, 1 Richard Osuala, 1 Sandy Napel, 37 Sara Colantonio, 38 Smriti Joshi, 1 Stefan Klein, 33 Susanna Aussó, 39 Wendy a Rogers, 40 Zohaib Salahuddin,41 Martijn P A Starmans 33;代表未来的ai联盟
Karim Lekadir, 1.2 Alejandro F Frangi, 3.4 Antonio R Porras, 5 Ben Glocker, 6 Celia Cintas, 7 Curtis P Langlotz, 8 Eva Weicken, 9 Folkert W Athsselbergs, 10.11 Fred Prior, 12 Gary S Collins, 13 Georgios Kaissis, 14 Gianna Tsakou, 15 Irène Bvat, 16 Jayashere Kalpathy-Cramer,17 John Mongan,18 Julia in Schnabel,19 Kaisar Kushibar,1 Katrine Riklund,20 Kostas Marias,21 Lameck M Amugongo,22 Lauren A Fromont,Fromont,23 Lena Maier-Hein,23 Lena Maier-Hein,24 LeonorCerdá-Alberich,25 luishirious,25 luiismartí,25 luiismartí-batifi。 Jorge Cardoso, 27 Maciej Bobowicz, 28 Mahsa Shabani, 29 Manolis Tsiknakis, 21 Maria in Zuluaga, 30 Marie-Christine Fritzsche, 31 Marina Camacho, 1 Marius George Linguraru, 32 Markus Wenzel, 9 Marleen de Bruijne, 33 Martin G Tolsgaard, 34 Melanie Goisauf, 35 Mónica Cano Abadía, 35 Nikolaos Papanikolaou, 36 Noussair Lazrak, 1 Orol Pujol, 1 Richard Osuala, 1 Sandy Napel, 37 Sara Colantonio, 38 Smriti Joshi, 1 Stefan Klein, 33 Susanna Aussó, 39 Wendy a Rogers, 40 Zohaib Salahuddin,41 Martijn P A Starmans 33;代表未来的ai联盟Karim Lekadir, 1.2 Alejandro F Frangi, 3.4 Antonio R Porras, 5 Ben Glocker, 6 Celia Cintas, 7 Curtis P Langlotz, 8 Eva Weicken, 9 Folkert W Athsselbergs, 10.11 Fred Prior, 12 Gary S Collins, 13 Georgios Kaissis, 14 Gianna Tsakou, 15 Irène Bvat, 16 Jayashere Kalpathy-Cramer,17 John Mongan,18 Julia in Schnabel,19 Kaisar Kushibar,1 Katrine Riklund,20 Kostas Marias,21 Lameck M Amugongo,22 Lauren A Fromont,Fromont,23 Lena Maier-Hein,23 Lena Maier-Hein,24 LeonorCerdá-Alberich,25 luishirious,25 luiismartí,25 luiismartí-batifi。 Jorge Cardoso, 27 Maciej Bobowicz, 28 Mahsa Shabani, 29 Manolis Tsiknakis, 21 Maria in Zuluaga, 30 Marie-Christine Fritzsche, 31 Marina Camacho, 1 Marius George Linguraru, 32 Markus Wenzel, 9 Marleen de Bruijne, 33 Martin G Tolsgaard, 34 Melanie Goisauf, 35 Mónica Cano Abadía, 35 Nikolaos Papanikolaou, 36 Noussair Lazrak, 1 Orol Pujol, 1 Richard Osuala, 1 Sandy Napel, 37 Sara Colantonio, 38 Smriti Joshi, 1 Stefan Klein, 33 Susanna Aussó, 39 Wendy a Rogers, 40 Zohaib Salahuddin,41 Martijn P A Starmans 33;代表未来的ai联盟
Karim Lekadir, 1.2 Alejandro F Frangi, 3.4 Antonio R Porras, 5 Ben Glocker, 6 Celia Cintas, 7 Curtis P Langlotz, 8 Eva Weicken, 9 Folkert W Athsselbergs, 10.11 Fred Prior, 12 Gary S Collins, 13 Georgios Kaissis, 14 Gianna Tsakou, 15 Irène Bvat, 16 Jayashere Kalpathy-Cramer,17 John Mongan,18 Julia in Schnabel,19 Kaisar Kushibar,1 Katrine Riklund,20 Kostas Marias,21 Lameck M Amugongo,22 Lauren A Fromont,Fromont,23 Lena Maier-Hein,23 Lena Maier-Hein,24 LeonorCerdá-Alberich,25 luishirious,25 luiismartí,25 luiismartí-batifi。 Jorge Cardoso, 27 Maciej Bobowicz, 28 Mahsa Shabani, 29 Manolis Tsiknakis, 21 Maria in Zuluaga, 30 Marie-Christine Fritzsche, 31 Marina Camacho, 1 Marius George Linguraru, 32 Markus Wenzel, 9 Marleen de Bruijne, 33 Martin G Tolsgaard, 34 Melanie Goisauf, 35 Mónica Cano Abadía, 35 Nikolaos Papanikolaou, 36 Noussair Lazrak, 1 Orol Pujol, 1 Richard Osuala, 1 Sandy Napel, 37 Sara Colantonio, 38 Smriti Joshi, 1 Stefan Klein, 33 Susanna Aussó, 39 Wendy a Rogers, 40 Zohaib Salahuddin,41 Martijn P A Starmans 33;代表未来的ai联盟Karim Lekadir, 1.2 Alejandro F Frangi, 3.4 Antonio R Porras, 5 Ben Glocker, 6 Celia Cintas, 7 Curtis P Langlotz, 8 Eva Weicken, 9 Folkert W Athsselbergs, 10.11 Fred Prior, 12 Gary S Collins, 13 Georgios Kaissis, 14 Gianna Tsakou, 15 Irène Bvat, 16 Jayashere Kalpathy-Cramer,17 John Mongan,18 Julia in Schnabel,19 Kaisar Kushibar,1 Katrine Riklund,20 Kostas Marias,21 Lameck M Amugongo,22 Lauren A Fromont,Fromont,23 Lena Maier-Hein,23 Lena Maier-Hein,24 LeonorCerdá-Alberich,25 luishirious,25 luiismartí,25 luiismartí-batifi。 Jorge Cardoso, 27 Maciej Bobowicz, 28 Mahsa Shabani, 29 Manolis Tsiknakis, 21 Maria in Zuluaga, 30 Marie-Christine Fritzsche, 31 Marina Camacho, 1 Marius George Linguraru, 32 Markus Wenzel, 9 Marleen de Bruijne, 33 Martin G Tolsgaard, 34 Melanie Goisauf, 35 Mónica Cano Abadía, 35 Nikolaos Papanikolaou, 36 Noussair Lazrak, 1 Orol Pujol, 1 Richard Osuala, 1 Sandy Napel, 37 Sara Colantonio, 38 Smriti Joshi, 1 Stefan Klein, 33 Susanna Aussó, 39 Wendy a Rogers, 40 Zohaib Salahuddin,41 Martijn P A Starmans 33;代表未来的ai联盟
* 欧盟委员会 – 竞争总司 – 信息技术、通信和媒体司。作者感谢 Brice Allibert、Inge Bernaerts、Friedrich Wenzel Bulst、Kassiani Christodoulou、Thomas Kramler、Luca Manigrassi、Linsey McCallum、Neale McDonald、Emily O'Reilly、Carlota Reyners Fontana、Annemarie Ter Heegde、Paolo Tomassi、Joao Vareda 和 Marc Zedler 对本摘要编写的宝贵意见和贡献。1 参见欧洲议会和理事会 2024 年 6 月 13 日颁布的 (EU) 2024/1689 条例,该条例规定了关于人工智能的协调规则并进行了修订(人工智能法)OJ L, 2024/1689,2024 年 7 月 12 日,第 99 和 105 条;欧盟委员会《关于在研究中负责任地使用生成式人工智能的现行指南》,ERA 论坛利益相关者文件,网址为 https://research-and-innovation.ec.europa.eu/document/download/2b6cf7e5-36ac-41cb-aab5-0d32050143dc_en?filename=ec_rtd_ai-guidelines.pdf,第 3 页。另请参阅 G7 竞争管理机构和政策制定者峰会数字竞争公报,2023 年 11 月 8 日,网址为 https://www.bundeskartellamt.de/SharedDocs/Publikation/EN/Others/G7 _2023_Communique.pdf?__blob=publicationFile&v=2。 2 请参阅委员会工作人员工作文件《欧盟关于 Web 4.0 和虚拟世界的倡议:下一次技术转型的先机》,网址为 https://digital-strategy.ec.europa.eu/en/library/staff-working-document-information-insights-and-market-trends-web-40-and-virtual-worlds,第 3 页和第 87 页。
3. Banerjee M、Bouillon B、Shafizadeh S 等。多发性创伤患者肢体损伤的流行病学。Injury 2013;44:1015-21。4. Lunevicius R、Mesri M。2011 年至 2018 年英格兰西北部主要创伤中心概况。Sci Rep 2021;11:5393。5. GBD 2019 骨折合作者。1990-2019 年 204 个国家和地区的全球、地区和国家骨折负担:2019 年全球疾病负担研究的系统分析。Lancet Healthy Longev 2021;2(9):e580-e592。6. Gawande A。两百年的外科手术。 N Engl J Med 2012;366:1716-23。7. Wenzel RP。手术部位感染和微生物组:最新视角。感染控制医院流行病学 2019;40:590-6。8. PREP-IT 研究人员。四肢骨折手术固定前的皮肤消毒。N Engl J Med 2024;390:409-20。9. Raineri EJM、Altulea D、van Dijl JM。葡萄球菌贩运和感染——从“鼻腔到肠道”再返回。FEMS Microbiol Rev 2022;46(1):fuab041。10. Hyoju S、Machutta K、Krezalek MA、Alverdy JC。肠道在伤口感染中起什么作用? Adv Surg 2023;57:31-46。
本教科书基于我在哥德堡大学和瑞典哥德堡的Chalmers技术大学提供的课程人工神经网络的讲义。当我准备讲座时,我的主要来源是Hertz,Krogh和Palmer [1]对神经计算理论的介绍。其他来源是神经网络:Haykin [2]的综合基础,霍纳的讲座注释[3],Heidelberg,Goodfellow,Bengio&Courville的深度学习[4],在线书籍神经网络和Nielsen的深度学习[5]。I thank Martin ˇ Cejka for typesetting the first version of my hand-written lecture notes, Erik Werner and Hampus Linander for their help in preparing Chapter 8, Kris- tian Gustafsson for his detailed feedback on Chapter 11, Nihat Ay for his comments on Section 4.5, and Mats Granath for discussions about autoencoders.I would also like to thank Juan Diego Arango, Oleksandr Balabanov, Anshuman Dubey, Johan Fries, Phillip Gräfensteiner, Navid Mousavi, Marina Rafajlovic, Jan Schiffeler, Ludvig Storm, and Arvid Wenzel Wartenberg for implementing algorithms described in this book.许多数字基于其结果。Oleksandr Balabanov,Anshuman Dubey,Jan Meibohm,尤其是Johan Fries和Marina Rafajlovic提出了考试问题,这些问题成为了本书的练习。最后,我要感谢StellanÖstlund的鼓励和批评。最后但并非最不重要的一点是,许多同事和学生(过去和现在)指出了错误的印刷和错误,并提出了改进。我感谢他们。目前的版本不包含练习(剑桥大学出版社拥有的版权)。完整的书可从剑桥大学出版社获得。
会增强对微生物和生态系统对干扰的反应的基本理解(图1)。城市化对包括多种微生物组的地球化学,气候和生物群产生了巨大影响。尽管目前的城市地区占全球土地地区的0.5%(Schneider等,2009),但城市土地覆盖范围仍在不断扩大,这可能对环境健康和可持续性有很大的影响(Seto等,2012)。城市化会导致景观碎片,从而减少动植物的生物植物(Delaney等,2010; Liang等,2008; Su等,2011)。城市的光线和声音污染可以改变动物的行为,破坏物种的相互作用,并导致物种丰富度和成分的转变(Ciach&Fröhlich,2017; Firbaugh&Haynes,2016; Francis et al。,2009; Longcore&Rich,2004)。城市中的土壤通常被有机污染物和重金属污染。这些污染物可以压力植物,污染植物组织,影响土壤和传粉动物群落,并为人类居民带来健康风险(Hern Andez&Pastor,2008; Pan等,2018; Pavao-Zuckerman&Coleman,2007; Wang等,2013)。通过温室气体排放(Pichler等,2017),大气氮的沉积(Fenn等,2003)和水污染(Overbo等,2021; Wright等,2011)。同时,城市环境维持关键的生态系统过程。昆虫的花粉可以在城市景观中壮成长,这使它们成为城市保护工作的重点(Baldock等,2019; Hall等,2017)。例如,庞大的城市地区继续提供足够的栖息地,资源和途径来支持高水平的生物多样性(Angold等,2006; Wenzel等,2020)。城市绿色空间可以通过过滤空气,调节气候和放缓径流来帮助抵消城市化的影响(Bolund&Hunhammar,1999; McPhearson等,2015)。城市土壤支持养分循环过程,并使用适当的
Elliot Israel,医学博士1,Loren C. Denlinger,医学博士,博士2,Leonard B. B. Bacharier,医学博士3,Lisa M. Lavange,PhD 4,Wendy C. Moore,MD 5,Michael C. Peters,Michael C. Peters,MD 6,MD 6,MD 6,Steve N. Georas,Georas,MD 7,MD J. Wright,Rosalind J. Wright,MD,MD,MD.M. PHD,PARD,PARD,PARD。 ,Praveen Akuthota,MD 11,Julia Bach,BSN,RN 2,Eugene R.Bleecker,MD 12,Juan Carlos Cardet,MD 13,Tara F. Carr,MD 12,Mario Castro,Mario Castro,MD,MD,MD,MPH 14,Angeles Cinelli,Cinelli,Ba 35,Ba 35,Suzy A.A. A.A. A.A. Comhair, PhD 15 , Ronina A. Covar, MD 16 , Laura Crotty Alexander, MD 11 , Emily A. DiMango, MD 17 , Serpil C. Erzurum, MD 15 , John V. Fahy, MD, MSc 6 , Merritt L. Fajt, MD 18 , Benjamin M Gaston, MD 19 , Eric A. Hoffman, PhD 20 , Fernando Holguin, MD,MPH 21,Daniel J. Jackson,医学博士2,Sonia Jain,Sonia Jain,PhD 11,Nizar N. Jarjour,MD 2,Yuan JI,Yuan JI,PhD 22,Nicholas J. Kenyon,MAS 23,MAS 23,Michael R. Kosorok,Michael R. Kosorok,Michael R. Kosorok,Phd 4,Monica Kraft,Monica Kraft,Monica Kraft,MD12,MD 12,MD 12,MD,JRISHNAN MD,LIE和MSERH MD,MSJESH KUM JUMJ,MSJESH KUMJ,MSJESH KUM JUMJ,MSJ,MSJ,MSJ, MD 26,21,Mark C. Liu,MD 27,Ngoc P. Ly,MD,MPH 6,M.Alison Marquis,Mstat 4,Mstat 4,Fernando D. Martinez,MD 12,James N. Moy,MD 28,Wanda K. O'Neal,PhD 29,Phd 29,Phd 29,Ph.罗斯,医学博士32,刘易斯·史密斯(Lewis J. A. Zeki,医学博士,MAS 23和Anastasia Ivanova,博士4