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CORM -3对TNBC的结构修改... -orca
鼠标抗GAPDH 37-0.2 µg/ml SC-32233鼠标抗Perk1/2 42/44 Y204 Y204 0.4 µg/ml SC-7383兔子抗PVEGFR2 152 Y1175 Y1175 Y1175 1.49 µg/ml AB-194806 rabbit andi-ps 60 Y41 Y419 0.538 y4419 Y4419 Y4419 Y419 AB-185617兔抗HO-1 32-1.0 µg/ml HC3001兔抗Pfak 119 Y397 Y397 1.0 µg/ml AB-81298
抑制剂JAB-23425
表2。JAB-23425抑制KRAS突变/扩增的癌细胞的生长。A. JAB-23425 IC 50 data in KRAS-dependent cancer cell lines harboring multiple KRAS mutations, by pERK T202/Y204 HTRF assays (2 h) and CTG viability assay (6 days).ND, not detected.* 2D CTG生存力测定。B. JAB-23425 IC 50 data in KRAS WT cell lines with or without KRAS amplification, by pERK T202/Y204 HTRF assay (2 h) and CTG viability assay (6 days).Viability of cancer cell lines having KRAS WT amplification (KRAS-dependent) was significantly inhibited by JAB-23425, while there is no obvious inhibitory effect of JAB-23425 on cancer or normal cell lines without KRAS mutation or amplification (KRAS-independent).SK-MEL-2和KU-19-19 NRAS Q61R突变和A375 Harbors BRAF V600E突变。ND, not detected.* 2D CTG生存力测定。