XiaoMi-AI文件搜索系统
World File Search Systembesides
除了药物靶向之外的挑战——多剂量鼻腔喷雾剂的监管障碍
鼻喷雾泵作为整体式 DDC（MDR）的示例 鼻喷雾泵的工作原理是将液体制剂转化为喷雾，然后将药物喷射到鼻腔。通过工业加工和无菌灌装，它们被填充相应的（无菌）制剂，并因此融合成单个整体产品，该产品专用于给定组合。此外，鼻喷雾泵不可重复使用。所有这些特性都是 MDR 第 1(9) 条的主题，该条引导读者了解以下监管策略：在这种情况下，DDC 受药品框架管辖，而设备部件（鼻喷雾泵）需要满足 MDR 附件 I 中概述的一般安全和性能要求 (GSPR)。
泛素 - 蛋白酶体系统是杀死抗顺铂的膀胱癌细胞
摘要。同源重组修复（HRR）是双链DNA（dsDNA）断裂无错误修复的细胞机制。在编码HRR的蛋白质（例如BRCA1和BRCA2）的基因等位基因中具有突变的癌细胞在修复过程中都有缺陷。 因此，这些细胞用替代机制（例如非同源末端连接）修复DsDNA破裂。 在BRCA1和BRCA2基因中具有种系突变的乳腺癌中，HRR缺陷会导致对PARP抑制剂的敏感性，这些药物干扰PARP酶功能并促进酶在DNA上的捕获以及修复单链断裂的过程。 HRR缺陷也导致对DNA损害化学疗法的敏感性，因为细胞无法修复化学疗法诱导的DNA病变。 除了BRCA1和BRCA2中的种系突变外，这些基因或种系中的体细胞突变以及体细胞突变，或其他涉及同源重组（HR）的基因的其他遗传和表观遗传变化可能会产生HRR缺陷，从而导致对PARP抑制剂的敏感性。 然而，研究的结论较少，这一事实可能与这些情况下通常缺乏双行性功能丧失有关，而不是通常会损失双行性功能的癌症BRCA1或BRCA2缺陷的癌症。 in癌细胞在修复过程中都有缺陷。因此，这些细胞用替代机制（例如非同源末端连接）修复DsDNA破裂。在BRCA1和BRCA2基因中具有种系突变的乳腺癌中，HRR缺陷会导致对PARP抑制剂的敏感性，这些药物干扰PARP酶功能并促进酶在DNA上的捕获以及修复单链断裂的过程。HRR缺陷也导致对DNA损害化学疗法的敏感性，因为细胞无法修复化学疗法诱导的DNA病变。除了BRCA1和BRCA2中的种系突变外，这些基因或种系中的体细胞突变以及体细胞突变，或其他涉及同源重组（HR）的基因的其他遗传和表观遗传变化可能会产生HRR缺陷，从而导致对PARP抑制剂的敏感性。然而，研究的结论较少，这一事实可能与这些情况下通常缺乏双行性功能丧失有关，而不是通常会损失双行性功能的癌症BRCA1或BRCA2缺陷的癌症。in
核苷酸和核酸
Important roles of other nucleotides: • Energy rich (high energies of hydrolysis, but kinetically stable) besides ATP, includes: GTP, CTP, UTP • Carrier molecule (key intermediates in metabolism) UDP-sugars, CDP-lipids, NADH, FAD • Secondary messengers (cAMP, cGMP) • Other cofactors for enzymes
基于a-lyapunov的诉讼 - 诉讼 - > ...
Abstract In many real-world reinforcement learning (RL) problems, besides optimizing the main objective function, an agent must concurrently avoid violating a number of constraints.In particular, besides optimizing performance, it is crucial to guar- antee the safety of an agent during training as well as deployment (e.g., a robot should avoid taking actions - exploratory or not - which irrevocably harm its hard- ware).To incorporate safety in RL, we derive algorithms under the framework of constrained Markov decision processes (CMDPs), an extension of the standard Markov decision processes (MDPs) augmented with constraints on expected cu- mulative costs.Our approach hinges on a novel Lyapunov method.We define and present a method for constructing Lyapunov functions, which provide an ef- fective way to guarantee the global safety of a behavior policy during training via a set of local linear constraints.Leveraging these theoretical underpinnings, we show how to use the Lyapunov approach to systematically transform dynamic programming (DP) and RL algorithms into their safe counterparts.To illustrate their effectiveness, we evaluate these algorithms in several CMDP planning and decision-making tasks on a safety benchmark domain.Our results show that our proposed method significantly outperforms existing baselines in balancing con- straint satisfaction and performance.
S＆T Prism（印度政府矿业部）www。 ...
•对于飞行员，提出了一个能够在72小时的铅锂PB 83 li 17中处理20 kg/批次的单个细胞系统•BARC和SARU SLU SMELTING PVT LTD（SSPL）已开发了实验室量表技术，已与BARC签订了一项技术转移协议。•SSPL在技术顾问的指导下开发了详细的工厂工程 - 技术顾问Riju Bhatnagar先生，已由Barc，Materials Group批准。•BARC将继续手持SSPL。as a mentor & incubating partners by providing their continued technical resources for trouble solvingh, testing & qualification besides also providing inter disciplinary expertise in fields of science & technology Name Of Presenter Shashank Jain/Rijju Bhatnagar, Mobile No 9837041182 E-mail shashank@sarumetals.com Proposed Budget Rs 116.5 Lakhs
电子商务管理学士学位（...
The School of Management, XMU, was granted accreditation The School of Management, XMU, was granted accreditation by AMBA (2011), EQUIS (2013) and AACSB (2020), joining a by AMBA (2011), EQUIS (2013) and AACSB (2020), joining a prestigious group of 1% business schools worldwide which prestigious group of 1% business schools worldwide which hold the “Triple冠军”。此外，根据“三冠王”的荣誉。Besides, according to the Tilburg University Worldwide Economics Schools Research Tilburg University Worldwide Economics Schools Research Ranking 2015, the School of Economics, XMU, was ranked Ranking 2015, the School of Economics, XMU, was ranked among the top 4 in China and 16th in Asia based on the number among the top 4 in China and 16th in Asia based on the number of articles published in prestigious international publications of articles从2011年到2015年发表在著名的国际出版物中。从2011年到2015年。
(ESIA) for conducting a
Himachal Pradesh State Road Transformation Project (HPSRTP) is an ambitious project of the Govt. of Himachal Pradesh under which it intends to strategically transform the Core Road Network of 2000 km road length. In the project, State Road Network roads of 650 km road length will be widened, and 1350 km road length will be provided periodic maintenance besides other institutional, development activities. Based on the outcome of the feasibility study of 2000 km length, 650 km of core roads have been prioritized for upgrading under Tranche-I, Tranche-II and Tranche-III project adopting appropriate contracting models. Now, HPRIDCL intends to Prepare Feasibility Study and Detailed Project Report for Selected Corridors in Himachal Pradesh of about 221 Km of additional MDR/ODR roads, with the expected outcome of upgradation and Detailed Engineering, including integration of Environment and Social aspects for the next tranche and will be used for improvement and up gradation of State Road network under Tranche-II.
范德华（Van der Waals）的应变工程的最新进展2D材料：可调电气，电化学，磁性和光学特性
对应物。[2]因此，2D材料非常适合柔性光电子，并且有可能用于下一代超薄电子和光电设备。[1]在2004年发现石墨烯时，首先实现了2D材料的概念。[4]石墨烯对其出色的电气，光学和机械性能引起了广泛的关注。[4-6]已经研究了各种技术应用，包括Spintronics，sensors，opetelectronics，SuperCapitors和Solar Cells等。[5,7] Besides graphene, other 2D materials, such as h-BN, phosphorene, silicene, germanene, and transition metal dichalcogenides (molybdenum disulfide (MoS 2 ), molybdenum diselenide (MoSe 2 ), tungsten disulfide (WS 2 ), and tungsten diselenide (WSe 2 ), etc.），近年来已经进行了广泛的研究。[1,8–11]单层二维材料的厚度通常在订单上或小于1 nm。同时，它们的侧向尺寸可以达到更大的尺寸（从微米到偶数英寸），并且在随后的处理或进行特征或设备应用程序的后续处理或后续测量之前，可以将2D材料转移到不同的基板上。
