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简历 - Rafael Cacao
● 德克萨斯理工大学 INFORMS 第 2022 章演讲比赛获胜者 ● 巴西公立学校数学奥林匹克 (2006 - 2009) 3 枚金牌和 1 枚铜牌 ● 5 月国际数学奥林匹克 (2007) 1 枚银牌，巴西数学奥林匹克 (2006) 1 枚铜牌 ● Arlindo de Andrade Gomes 博士功绩荣誉奖章 ● 德克萨斯理工大学 JT 和 Margaret Talkington 奖学金和 TTU Whitacre 工程学院奖学金 ● 巴西 CAPES 科学无国界奖学金
更新04.03.2025.pdf -Portal Gov.br
BioagrosscurióVitalBrasil化学工业和化学商业LTDA -ME 19021 Beauveria Bassiana，孤立的IBCB 66 + Anisopliae，孤立的IBCB 425微生物昆虫学
npr1样基因可可瘤：进化洞察力和增强对植物含量的抗性性的潜力
与发病机理相关1（NPR1）的非XPRessor对于通过信号分子水杨酸（SA）激活植物免疫系统至关重要，这会触发拟南芥的全身性获得性（SAR）。在这项研究中，已经在Cacao的基因组中鉴定出了三个与NPR1相关的假定基因，即TCNPR1，TCNPR2和TCNPR3，这表明这三个基因实体之间的功能多样化表明。系统发育分析表明，TCNPR1和TCNPR2与它们的拟南芥直系同源物NPR1和NPR2一起分支，表明这些基因在不同物种的SA信号传导途径中保持了保守的作用。相比之下，TCNPR3存在于单独的进化枝中，表明了独特的功能作用和进化差异。对这些TCNPR的生理化学特性的比较分析显示出不同的亚细胞定位，因为TCNPR1在细胞质中持续存在，而TCNPR3在细胞核中发现，与其在SA信号传导和转录性调节中的作用保持一致。此外，我们确定了针对TCNPR3的microRNA，这表明P. Megakarya可能会利用转录调节网络绕过植物防御激活。通过RNA干扰介导的基因沉默对TCNPR基因的瞬时过表达或抑制可能足以研究对其他分子的产生的影响，例如SA，某些PR蛋白表达以及对巨疟原虫的抗性。由TCNPRS编码的蛋白质与P. megakarya的细胞蛋白质之间的相互作用将提供有关Patho Gen是否操纵宿主防御的洞察力。最后，P。Megakarya响应感染TCNPR基因的表达提供了有关防御反应过程中时间和空间激活的有价值的信息。
sancao汤剂与顺铂结合减轻乳腺癌的肺转移，可缓解前转移性壁niche
摘要背景：中医化合物Sancao汤（SCD）是调节免疫力的民间处方。它由8种中草药，例如Prunellae Spica（Xiakucao），Houttuyniae Herba（Yuxingcao），Lysimimachiae Herba（Jinqiancao）等。在癌症中，白介素-6（IL-6）/转录3（STAT3）途径的信号传感器和激活因素直接促进癌细胞的增殖，存活和血管生成，精氨酸酶-1（ARG-1）是骨髓机源性抑制细胞（MDSCS）的关键酶，以促进免疫功能。尚不清楚SCD是否通过IL-6/STAT3途径调节MDSC中ARG-1的表达。因此，我们探讨了SCD对乳腺癌肺转移的作用和机制。方法：SCD中的组件已通过HPLC-MS分析。通过将4T1细胞注入BALB/C小鼠的乳腺脂肪垫中，建立了乳腺癌的自发转移模型。通过肺转移结节，肺病理学测试和免疫荧光评估2-4周，评估了 te-div>用肺转移结节，肺病理测试和免疫荧光评估SCD对PMN的作用。 血清测试和苏木精 - 欧洲蛋白染色（H＆E）用于评估顺铂的副作用。 Western印迹和ELISA用于检测小鼠肺组织中Stat3信号通路的蛋白质和细胞因子。 结果：与仅SCD或顺铂治疗相比，SCD/顺铂（CP）协同给药不仅显着抑制了正交性乳腺肿瘤的生长，而且还减少了肺转移，并减少了CP诱导的肝毒性。te-div>用肺转移结节，肺病理测试和免疫荧光评估SCD对PMN的作用。血清测试和苏木精 - 欧洲蛋白染色（H＆E）用于评估顺铂的副作用。Western印迹和ELISA用于检测小鼠肺组织中Stat3信号通路的蛋白质和细胞因子。结果：与仅SCD或顺铂治疗相比，SCD/顺铂（CP）协同给药不仅显着抑制了正交性乳腺肿瘤的生长，而且还减少了肺转移，并减少了CP诱导的肝毒性。值得注意的是，该组合有效地抑制了PMN的形成和MDSC在肺PMN中的积累，并伴随着CD4
Sands China与Alipay和Macau Pass合作，成功地引入了创新的Aripay Tap！在澳门
2025年1月14日，简化国内和国际游客的付款，Sands China Ltd.，Alipay和Macau Pass共同引入了Aripay Tap！服务
认证实践澳门邮政和电信eSigntrust认证服务版权所有©Correios ETelecomunicaçõe
4.4.1。Conduct constituting certificate acceptance ................................................................... 35 4.4.2.CA出版证书............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 35 4.4.3。Notification of certificate issuance by the CA to other entities ....................................... 35 4.5.k ey p air and c ertificate u sage ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 36 4.5.1。Subscriber private key and certificate usage .................................................................. 36 4.5.2.Relying party public key and certificate usage ............................................................... 36 4.6.C ERTIFICATE R ENEWAL ....................................................................................................... 36 4.6.1.Circumstance for certificate renewal.............................................................................. 36 4.6.2. Who may request renewal ............................................................................................... 36 4.6.3.处理证书续订请求........................................................................................................................................................................................................................................................................................................................................................................................... 36 4.6.4。Notification of new certificate issuance to subscriber .................................................... 36 4.6.5.行为构成续签证书的接受............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 37 4.6.6。CA出版的续签证书................................................................................................................................................................................................................ 37 4.6.7。Notification of certificate issuance by the CA to other entities ....................................... 37 4.7.C ERTIFICATE R E - KEY ........................................................................................................... 37 4.7.1.Circumstance for certificate re-key ................................................................................ 37 4.7.2. Who may request certification of a new public key ....................................................... 37 4.7.3.Processing certificate re-keying requests ....................................................................... 37 4.7.4.Notification of new certificate issuance to subscriber .................................................... 37 4.7.5.Conduct constituting acceptance of a re-keyed certificate ............................................. 37 4.7.6.CA由CA的重新钥匙证书出版............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 38 4.7.7Notification of certificate issuance by the CA to other entities ....................................... 38 4.8.c or毒性..................................................................................................................................................................................................................................................................... 38 4.8.1。证书修改的情况............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 38 4.8.2。谁可以要求修改证书............................................................................................................................ 38 4.8.3。处理证书修改请求.......................................................................................................................................................................................... 38 4.8.4。Notification of new certificate issuance to subscriber .................................................... 38 4.8.5.Conduct constituting acceptance of modified certificate ................................................ 38 4.8.6.Publication of the modified certificate by the CA ........................................................... 38 4.8.7.Notification of certificate issuance by the CA to other entities ....................................... 38 4.9.C ERTIFICATE R EVOCATION AND S USPENSION ...................................................................... 39 4.9.1.Circumstances for revocation ......................................................................................... 39 4.9.2. Who can request revocation ........................................................................................... 39 4.9.3.Procedure for revocation request ................................................................................... 39 4.9.4.Revocation request grace period .................................................................................... 40 4.9.5.CA必须处理撤销请求的时间....................................................................................................................................................................................................................................................................................................................................... 40 4.9.6。撤销检查要求依赖方............................................................................................................................................................................................................................ 41 4.9.7。CRL issuance frequency ................................................................................................. 41 4.9.8.Maximum latency for CRLs ............................................................................................ 41 4.9.9.在线撤销/状态检查可用性........................................................................................................................................................................................................................................................................................................ 41 4.9.10。 On-line revocation checking requirements ..................................................................... 41 4.9.11. 其他形式的吊销广告可用................................................................................................................................................................................................................. 41 4.9.12。 Special requirement re-key compromise ......................................................................... 41 4.9.13. 悬架的情况...................................................................................................................................................................................................................... 42 4.9.14。 Who can request suspension ........................................................................................... 42 4.9.15. Procedure for suspension request ................................................................................... 42 4.9.16. 暂停期限的限制....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 42 4.10。 C ERTIFICATE S TATUS S ERVICES ........................................................................................... 43 4.10.1. Operational characteristics ............................................................................................ 43 4.10.2. Services availability ........................................................................................................ 43 4.10.3. Optional features ............................................................................................................ 43 4.11. Session key encapsulation and recovery policy and practices ........................................ 43在线撤销/状态检查可用性........................................................................................................................................................................................................................................................................................................ 41 4.9.10。On-line revocation checking requirements ..................................................................... 41 4.9.11.其他形式的吊销广告可用................................................................................................................................................................................................................. 41 4.9.12。Special requirement re-key compromise ......................................................................... 41 4.9.13.悬架的情况...................................................................................................................................................................................................................... 42 4.9.14。 Who can request suspension ........................................................................................... 42 4.9.15.Procedure for suspension request ................................................................................... 42 4.9.16.暂停期限的限制....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 42 4.10。C ERTIFICATE S TATUS S ERVICES ........................................................................................... 43 4.10.1.Operational characteristics ............................................................................................ 43 4.10.2.Services availability ........................................................................................................ 43 4.10.3.Optional features ............................................................................................................ 43 4.11.Session key encapsulation and recovery policy and practices ........................................ 43E ND OF S UBSCRIPTION ......................................................................................................... 43 4.12.K EY E SCROW AND R ECOVERY ............................................................................................. 43 4.12.1.Key Escrow and recovery policy and practices .............................................................. 43 4.12.2.
高质量单类石墨烯，区域
总结在这项研究中，低压蒸汽的方法用于使高质量的单层石墨烯具有铜板表面大面积的高面积。石墨烯的形成和质量受到基础CH4：H2的温度和比率的显着影响。最佳类单层石墨烯是在约1000°C的温度下进行的，生长周期为120分钟，而CH4：H2的比率为35：6 SCCM。反应室中的总压力在1.0至1.2托尔的范围内变化。峰值2d（〜63.43 cm-1）的峰（FWHM）与拉曼光谱的峰i2d/ig（〜3,10）的强度之比证实了单层石墨烯。石墨烯微不足道和高均匀性的残疾通过低圆形拉曼峰证实。已经评估了许多Khaists的温度和压力参数，是合成高品质石墨烯的最佳选择，有望在光学，电化学，电子和有毒气体传感器的领域打开新应用。