从愿景开始:6个步骤,有效地计划,创建解决方案并采取行动2021年11月17日|上午8:30 - 下午4:30当要求员工面临最大的挑战时,回答范围为“我对盘子上的一切感到不知所措”到“我们有一个很好的机会,但我们不能让所有人保持一致。”答案范围很广,但是它们都共享一个共同的问题 - 他们需要一个实用,易于管理的计划过程,并将有助于发展前进的方向。成为您花在了50多个组织的研究中,成为您如何计划和问题解决的50多个组织,以确定有效和无效的问题。发现不到10%的领导者有计划或解决问题的过程很有趣。要缩小差距的计划方法,即六步过程,诞生了。该计划将利用六步流程为个人和团队提供一个过程,以解决他们最大的问题,并制定一个明确的计划,以解决谁在解决问题时会做什么。六步过程是许多成功组织用于解决其最大挑战的过程。虽然它将适用于任何组织问题或机会,但人们也可以使用它来解决他们可能面临的任何个人挑战。在此实践和互动计划中,每个领导者将解决他们面临的最重要的问题 - 个人或专业的问题 - 然后使用六步过程来找到解决方案并制定计划来解决该解决方案。这种体验将提供您在个人和职业生活中可能一次又一次使用的过程!此程序将帮助领导者:可以立即将六步过程带回您的团队,以解决任何问题,直到成为您文化的一部分。
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•具有同源修复缺陷(HRD)的肿瘤对中断DNA修复的药物敏感。去泛素酶USP1涉及Translesion合成和Fanconi贫血途径的DNA损伤反应。和USP1和HRD的合成致死性得到很好的报道。此外,USP1或其下游途径的缺乏会导致HRD肿瘤对PARP抑制过敏。•此外,与靶标相关的造血毒性被广泛观察到在包括PARP和ATR抑制剂在内的serval DNA损伤反应(DDR)途径抑制剂,这限制了联合疗法。•在这里,我们报道了SP-002是一种有效的USP1抑制剂,在HRD癌症中显示了与PARP抑制剂(PARPI)的单一疗法潜力和组合活性。
本文介绍了一种具有集成多模干涉耦合器的新锥形半导体激光器。新激光器的种子来源是多模干扰耦合器半导体激光器,它克服了脊方波导区域中单模式输出与增益中等体积之间关系所带来的局限性。The simulation results show that the multi-mode interference coupler can effectively provide a spatial single- mode seed light source for the tapered output waveguide, and the tapered output waveguide of the tapered semiconductor laser can also effectively reduce the optical power density of the output laser, which verifies the feasibility of the design scheme and provides a new idea for the design of high beam quality and high power tapered半导体激光器。
Given the scale and importance of scope 3 target-setting, and an increasing urgency for action, the SBTi has launched a process to review and update scope 3 target-setting guidance, methods, and criteria with the aim of ensuring the framework effectively catalyzes value-chain decarbonization while being cognisant of barriers corporates face.
在此综合报告中,就当前计划,估计,策略和信念以及其他不是历史事实的陈述所作的陈述是关于阿斯特拉斯未来表现的前瞻性陈述。这些陈述是根据当前可用的信息,涉及已知和未知的风险和不确定性的信息,基于管理层当前的假设和信念。许多因素可能导致实际结果与前瞻性陈述中讨论的结果有重大差异。Such factors include, but are not limited to: (i) changes in general economic conditions and in laws and regulations relating to pharmaceutical markets, (ii) currency exchange rate fluctuations, (iii) delays in new product launches, (iv) the inability of Astellas to market existing and new products effectively, (v) the inability of Astellas to continue to effectively research and develop products accepted by customers in highly competitive markets, and (vi)第三方侵犯阿斯特拉斯的知识产权。有关药品的信息(包括目前正在开发的产品)中,该综合报告中包含的信息并不构成广告或医疗建议。
在此材料中,关于当前计划,估计,策略和信念以及其他不是历史事实的陈述的陈述是关于Astellas Pharma的未来表现的前瞻性陈述。这些陈述是根据当前可用的信息,涉及已知和未知的风险和不确定性的信息,基于管理层当前的假设和信念。许多因素可能导致实际结果与前瞻性陈述中讨论的结果有重大差异。Such factors include, but are not limited to: (i) changes in general economic conditions and in laws and regulations relating to pharmaceutical markets, (ii) currency exchange rate fluctuations, (iii) delays in new product launches, (iv) the inability of Astellas to market existing and new products effectively, (v) the inability of Astellas to continue to effectively research and develop products accepted by customers in highly competitive markets, and (vi)第三方侵犯了阿斯特拉斯的知识产权。关于药品(包括目前正在开发的产品)的信息不构成广告或医疗建议。
Shaping tomorrow's HR: Market trends and real- world insights Redefining employee experience: The role of total rewards, mental health and job transitions Succession planning in action: Challenges, approaches, and best practices Supporting leaders to effectively address psychosocial risks & build workplace trust Enhancing leadership impact: The strategic power of micro-pauses
Builds and maintains strong internal and external customer and other relationships relevant to role Is able to effectively understand and support customer needs while balancing business needs Takes responsibility for meeting agreed service levels and other commitments Strives to deliver excellence and innovates to deliver solutions Ensures that everything that they do complies with all Treating Customers Fairly (TCF) principles
Management actions identified (including enforcement, communication, collaboration, monitoring, reporting and reassessment) and implemented to substantially/ effectively reduce human induced extinction of known threatened species and for the recovery and conservation of species, to significantly reduce extinction risk, as well as to maintain and restore the genetic diversity while managing human-wildlife interactions to minimise conflicts (including the empowerment of Indigenous peoples and local communities to support这样的行动)。