XiaoMi-AI文件搜索系统
World File Search Systemespecially
业务发展主管 - 伦敦
• New business development activities especially in infrastructure (including electricity) sector • Work closely with related external parties to promote new business development • Work closely with internal parties including the Head Quarters in Japan • Business travel to European countries is required (c. once per month) • Initiate and lead cross-border business development • Develop deal leads and manage projects through to completion whether that be investing, partnering or acquiring new companies • Interact closely with internal and external expert groups to gather industry and market information •开发新的网络/联系人/客户群•解释内部和外部业务挑战，并建议最佳的基于实践的解决方案•带领其他人解决复杂的问题并确定创新的解决方案•在欧洲地区内部和外部的SCEU充当SCEU的大使•塑造并指导我们的部门战略与总部与欧洲国家的业务旅行•需要商业旅行•需要提供商业旅行（c。每月一次）。资格/技能/个人素质/经验
血液学疾病中的全反式视黄酸
全反式视黄酸（ATRA）在组织发育，神经功能，繁殖，视力，细胞生长和分化，肿瘤免疫和凋亡中起作用。ATRA可以通过诱导自噬信号传导，血管生成，细胞分化，凋亡和免疫功能来起作用。在血液系统中，ATRA首先是在急性寄生虫细胞白血病（APL）中成功使用的，其中ATRA将白血病细胞分化为成熟的粒细胞。ATRA can play a role not only in APL, but may also play a role in other hematologic diseases such as immune thrombocytopenia (ITP), myelodysplastic syndromes (MDS), non-APL acute myeloid leukemia (AML), aplastic anemia (AA), multiple myeloma (MM), etc., especially by regulating mesenchymal stem cells and调节性T细胞用于治疗ITP。ATRA还可以增加肿瘤细胞表达的CD38的表达，从而改善了daratumumumab和cd38-cart的效率。在这篇综述中，我们关注ATRA的作用机理，其在各种血液疾病，药物组合和持续的临床试验中的作用。
揭开数字海市rage楼-Cense
虚拟资产无疑对金融机构的运营模型提出了复杂的挑战，严重影响了客户的尽职调查（“ CDD”），并了解您的客户（“ KYC”）流程。与虚拟资产相关的欺诈活动的增加导致许多金融机构与从事这些活动的用户断开联系。这种趋势通常是对减轻风险的回应，并避免了依从性成本的升级，也因对主要虚拟资产服务提供商的监管镇压而放大了。传统金融机构越来越远离与虚拟资产相互作用的用户疏远，这对他们与主流金融系统的脱节可能引起的潜在风险保持警惕。This cautious approach is further reinforced by banking regulators' hesitance to engage with crypto clients, especially given the intensified scrutiny by the US Securities and Exchange Commission The 2018 Thomson Reuters report on the “True Cost of Financial Crime”, which gathered responses from 2,373 C-suite and senior management professionals in large organizations, revealed a noteworthy preference: 72% of these leaders opted to minimize risk by避免使用高风险的客户，而不是管理相关风险。
牛子宫微生物群
Taina Lorraine Pereira Azevedo 1，Gabriela Geraldo de Lima 2，Jessica daPaz²RodrigoGarcia Motta，Antonio CampaignMartinez³，1名硕士学位学生，是MaringáState University（UEM）的动物和可持续生产研究生和可持续生产的硕士学生，2居住在玛格拉山州立大学（UEM）的动物繁殖和产科中，UMUARAMA -PR。``玛格拉山州立大学兽医医学课程（UEM）的兽医课程。“玛格拉拉玛拉马州玛那州立大学兽医医学课程（UEM）的动物繁殖区域不良教授 - PR。电子邮件：tainalpazevedo@gmail.com接收到：15/05/2024批准：15/06/2024发布：30/06/2024 doi：10.18677/encibio_2024b15通过识别和特征的构想，允许识别和特征的素质范围，牛的生殖功效。子宫长期以来一直被认为是无菌环境，最近的研究证明，有一个动态的局部微生物群，由细菌，原生动物和真菌等多种微生物组成。The composition of uterine microbial is varied by several factors such as the estRal cycle phase, number of raising, age, race, genetics, stress, gestational period, puberty, nutrition, dysstocia, attendance, presence of contamination, season, accommodation, systemic diseases and, especially, inflammatory diseases in postpartum, classified in metrite, endometrite Subclinical, clinical endometitis. 关键字：微生物瘤；反刍动物；子宫。The composition of uterine microbial is varied by several factors such as the estRal cycle phase, number of raising, age, race, genetics, stress, gestational period, puberty, nutrition, dysstocia, attendance, presence of contamination, season, accommodation, systemic diseases and, especially, inflammatory diseases in postpartum, classified in metrite, endometrite Subclinical, clinical endometitis.关键字：微生物瘤；反刍动物；子宫。与临床和亚临床内测量炎相比，健康的子宫在属和物种中具有更大的细菌多样性。孤立的健康动物子宫中24种流派的细菌是分离出的，具有较高的葡萄球菌，大肠杆菌，芽孢杆菌。在患有临床子宫内膜炎的母牛中发现了22种流派，主要的Truepela Escherichia和葡萄球菌。在患有亚临床内炎的奶牛中仅鉴定出12种细菌类型：芽孢杆菌，肠球菌，假单胞菌。子宫疾病可能会导致牛奶产量，生育能力下降，牛奶和动物处置以及对子宫微生物组的理解，以及细菌对马关炎的影响和子宫内在的影响以提高母牛的生殖效率。
Post-transplant Malignancies: Current Perspective on Risk Factors, Prevention, and Management
Post-transplant malignancies arise from a complex interplay of factors, with immunosuppression playing a pivotal role. Chronic immunosuppressive treatment compromises the recipient's immune system, rendering it less efficient at recog- nizing and eliminating malignant cells. Additionally, viral infections, especially Epstein–Barr virus and Human papilloma- virus, are major contributors to malignancy development. Lifestyle modifications, including smoking cessation and sun protection, are recommended for reducing certain cancer risks. Regular screening for malignancies may provide the early diagnosis as in the general population. After the diagnosis of cancer, tailoring immunosuppressive regimens to maintain graft function is crucial. Treatment options, such as chemotherapies, targeted therapies, and immunotherapies, should be selected with consideration of the patient's overall health and the potential impact on the transplanted organ. A multidis- ciplinary approach is required in order to provide optimal treatment to our kidney transplant recipients. With this review article, we aim to discuss pathophysiological mechanisms, review guidelines, and provide information on the incidence and management options for various cancers. Keywords: Immune checkpoint inhibitors, malignancy, prevention, kidney transplantation, screening
cOVID-19诱导CNS细胞因子表达和海马神经发生的丧失
严重急性呼吸道综合征2（SARS-COV-2）感染与急性和急性认知和神经精神症状有关，包括记忆力受损，浓度，注意力，睡眠和AFECT。这些大脑症状背后的机制仍在研究。在这里，我们报告说，尽管血液异常 - 脑屏障的通透性异常，但SARS-COV-2感染的仓鼠表现出缺乏病毒神经侵袭。Hamsters and patients deceased from coronavirus disease 2019 (COVID-19) also exhibit microglial activation and expression of interleukin (IL)-1 β and IL-6, especially within the hippocampus and the medulla oblongata, when compared with non-COVID control hamsters and humans who died from other infections, cardiovascular disease, uraemia or trauma.在Covid-19仓鼠和人类的海马齿状回中，我们观察到更少的神经爆炸和未成熟的神经元。持续的炎症，血液 - 脑屏障破坏和小胶质细胞激活可能会导致神经传递，神经发生和神经元损害改变，从而解释了Covid-19的神经精神上的表现。海马的参与可能解释了COVID-19患者的学习，记忆和执行功能障碍。
拓扑结节点超导二 -
摘要：二维（2D）杂交有机 - 无机渗透性滑石（HOIP）具有增强的稳定性，高可调性和强型自旋 - 轨道耦合，在广泛的应用中显示出很大的潜力。在这里，我们将2D HOIP的已经丰富的功能扩展到了一个新的领域，实现了拓扑超导性和主要量子计算模式。Especially, we predict that room- temperature ferroelectric BA 2 PbCl 4 (BA for benzylammonium) exhibits topological nodal-point superconductivity (NSC) and gapless Majorana modes on selected edges and ferroelectric domain walls when proximity- coupled to an s-wave superconductor and an in-plane Zeeman field, attractive for experimental verification and application.由于NSC受2D HOIP的空间对称性保护，因此我们设想在此类材料中可以找到更多外来的拓扑超导状态，因为它们的多种非中性空间组可能会在HOIPS和拓扑超导率的田间开设新的途径。关键字：二维，铁电混合钙蛋白，拓扑结节点超导性，边缘/域 - 墙壁Majoragara模式
甘蔗育种：技术和方法驱动的奇妙的过去和有希望的未来
甘蔗是世界上最重要的糖和能源作物。在甘蔗育种期间，技术是需求，方法是手段。我们知道，种子是甘蔗产业发展的基石。Over the past century, with the advancement of technology and the expansion of methods, sugarcane breeding has continued to improve, and sugarcane production has realized a leaping growth, providing a large amount of essential sugar and clean energy for the long-term mankind development, especially in the face of the future threats of world population explosion, reduction of available arable land, and various biotic and abiotic stresses.Moreover, due to narrow genetic foundation, serious varietal degradation, lack of breakthrough varieties, as well as long breeding cycle and low probability of gene polymerization, it is particularly important to realize the leapfrog development of sugarcane breeding by seizing the opportunity for the emerging Breeding 4.0, and making full use of modern biotechnology including but not limited to whole genome selection, transgene, gene editing, and synthetic生物学，结合遥感和深度学习等信息技术。鉴于此，我们从技术和方法的角度专注于甘蔗育种，回顾了主要历史，指出了当前的状态和挑战，并为智能育种前景提供了合理的前景。
珊瑚礁中的生物多样性
Explain how the use of different energy resources affects the environment and the economy (SE- M-A6) Analyze positive and negative effects of human actions on ecosystems (LS-H-D4) (SE-H-A7) Identify resources humans derive from ecosystems (SE-M-A1) Rationale and suggested sequence for reading: The intent of this pack is to build knowledge round the coral reef, especially about the biodiversity with in the珊瑚礁和对人类和自然的礁石的威胁。包装随着文本的进展而增加，从事实语句和息肉图开始，整个珊瑚礁都是从建造的动物开始的，然后使用书面和视觉来源进行探索生物多样性。最复杂的文本描述了对礁石的威胁，包装以一篇文章结束，该文章将生物多样性和威胁的概念融合在一起，而螃蟹将礁石从入侵的海星中拯救出来。学生会发现，随着单词在不同的环境中重复的单词重复时，他们会发现越来越易于访问的第2层和域特异性词汇，并且发现该生态系统的微妙平衡将支持他们学习其他生态系统，海洋生命以及自然和人类对环境的影响的能力。ELA/读写能力的共同核心变化：
标题：BACTEC方法的验证和可比性...
不育测试是CAR -T（嵌合抗原受体T细胞）疗法的批处理释放过程中的重要和关键步骤。CAR -T疗法涉及基因工程患者自己的T细胞靶向和破坏癌细胞。这些疗法通常用于治疗患有严重癌症的患者，尤其是血液学恶性肿瘤。鉴于CAR -T治疗的高度专业化和接受它们的患者的免疫功能低下的状态，确保这些疗法的无菌性至关重要。与典型的方式不同，细胞和基因疗法是生命最终产品。但是，区分所需的活细胞（例如T细胞）和不希望的成分（例如细菌，真菌）至关重要。This is especially vital for autologous CAR‐T cells therapies as each small batch must be tested due to limited volume, and rapid testing is essential to ensure timely delivery for patient treatment (Source: https://www.pharmtech.com/view/contamination‐control‐for‐cell‐and‐gene‐therapies‐needs‐ new‐analytics).该行业使用的标准参考是汇编不育测试，涉及将微生物直接接种到培养基中（Ph.Eur。第2.6.1章和USP <71>）。此方法需要14天，并因其遵守监管标准和可靠性而被该行业认可。