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代谢相关脂肪肝和胰岛素抵抗儿童外周血单核细胞表达的 miRNA 谱
1. Fazel Y、Koenig AB、Sayiner M、Goodman ZD、Younossi ZM。非酒精性脂肪性肝病的流行病学和自然史。代谢。2016；65(8):1017-1025。2. Marchesini G、Brizi M、Bianchi G 等人。非酒精性脂肪性肝病 2001；50。3. Lonardo A、Nascimbeni F、Maurantonio M、Marrazzo A、Rinaldi L、Adinolfi LE。非酒精性脂肪性肝病：不断发展的范式。世界胃肠病杂志。2017；23(36):6571-6592。4. Stefan N、Hans-Ulrich Häring KC。非酒精性脂肪性肝病：病因、诊断、心脏代谢后果和治疗策略。柳叶刀糖尿病内分泌学。2019；4：313-324。5. Newton KP、Hou J、Crimmins NA 等人。非酒精性脂肪性肝病儿童中 2 型糖尿病和糖尿病前期的患病率 Kimberly。JAMA Pediatr。2016；170(10):e161971。6. Eslam M、Newsome PN、Sarin SK 等人。代谢功能障碍相关脂肪性肝病的新定义：国际专家共识声明。J Hepatol。2020；73(1):202-209。doi: 10.1016/j。 jhep.2020.03.039 7. Eslam M, Alkhouri N, Vajro P 等。定义儿童代谢（功能障碍）相关脂肪肝疾病：国际专家共识声明。柳叶刀胃肠肝病。2021；6(10): 864-873。
在大米中高夜温度压力下差异表达基因的启动子中的保守域：如何找到它们，它们能告诉我们什么？
抽象作物植物对压力的反应涉及基因表达模式的变化。这种基因调节的复杂过程取决于顺式和反式作用成分的存在。理解与植物对胁迫反应相关的基因表达变化的关键步骤之一始于鉴定差异表达基因（DEGS）启动子中“保守域”的鉴定。保守域可以通过为转录因子提供结合位点在基因调节中起关键作用。在这项研究中，我们旨在确定149摄氏度的启动子中的顺式调节元件（CRE），这些元素在两个水稻品种的转录组分析中被鉴定出来：cypress and Lagrue。这两个水稻品种根据其承受热应激的能力，在高夜晚（HNT）下分别表现良好。可以预期，受Hnt应力向上或向下调节的DEG要么在其启动子中表现出一组共享的CRE，要么在特定DEG模式中共有多态模式，其识别可以帮助理解植物对压力的各种反应。将使用多种计算方法来找到与水稻中HNT应力有关的顺式作用元件 /转录激活基序。这些信息将在机器学习算法中利用，以开发针对繁殖目的操纵基因的预测模型，例如提高谷物质量和产量，从而增强了水稻植物对高夜间温度的韧性，并为水稻作物的整体适应性做出了贡献。
datopotamab deruxtecan（dato-dxd）增强了对小鼠中trop2-表达肿瘤pd-1/pd-l1抑制剂的抗肿瘤反应
• Trophoblast cell surface antigen 2 (TROP2) is a 36-kDa single-pass transmembrane protein which is widely expressed in solid tumors, and highly expressed in non-small cell lung cancer (NSCLC), hormone receptor positive breast cancer (HR+BC) and triple negative breast cancer (TNBC) 1 , supporting the therapeutic potential of TROP2- directed therapies in these跨不同治疗线的肿瘤类型
Economic Impact of Closing the Nuclear Fuel Cycle
DISCLAIMER This information was prepared as an account of work sponsored by an agency of the U.S. Government. Neither the U.S. Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness, of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. References herein to any specific commercial product, process, or service by trade name, trade mark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the U.S. Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the U.S. Government or any agency thereof.
e x p e rt o p i n i o n o n挑战和策略改善了马来西亚获得癌症药物的机会：在
摘要：近几十年来，癌症药物开发取得了很大进展。但是，对于包括马来西亚在内的低收入和中等收入国家的人们，其中许多药物不容易获得。在第二马来西亚癌症研究协会（MACR）国际科学会议期间，举行了论坛讨论，以应对这些挑战，并探索改善该国癌症药物的策略。本文介绍了上述论坛讨论的结果。强调了癌症药物进入的一些挑战，包括冗长的认可和监管实践，药品成本和制造障碍。此外，提出了一些减轻其中一些挑战的策略，例如降低成本的机制，吸收生物仿制药和仿制药，本地制造业，公共私人伙伴关系，加强保险公司的作用，资金和监管，资金和监管，以及从癌症疾病的疾病中，促进了药物访问型脱不同的疾病。总体而言，本文概述了改善马来西亚癌症药物的挑战和策略，并为政策制定者，医疗保健提供者，制药行业，癌症患者，癌症支持小组以及其他从事这一重要问题工作的利益相关者提供了宝贵的见解。关键词：癌症药物获取，癌症治疗，马来西亚，非公平癌症药物分布
梅加拉亚邦将在未来五年内将其GSDP翻一番，达到100亿美元，以实现总理纳伦德拉·莫迪（Narendra Modi）设定的目标
He also expressed his confidence that NITI Aayog's fundamental approach of cooperative federalism will promote good governance and will guide the achievement of the vision of ‘Aatma Nirbhar Bharat'.Elaborating on doubling the GSDP, the chief minister stated that Meghalaya has identified six pillars - Human Capital Development, Primary Sector Rejuvenation, Infrastructure Development, Entrepreneurship, Environment and Governance.
molecular-quantitative-trait-loci-in-reproductive-tissues- ...
Testis Epididymis Vas deferens Samples 117 103 84 Expressed genes 20,222 20,376 19,063 eQTL 15,642 4,768 4,211 eGenes 11,164 4,347 3,889 eGenes with >1 eQTL 3,647 402 310 eVariants 3,687,265 925,916 673,696个剪接基因14,243 13,558 12,332 SQTL 11,450 3,165 1,920 Sgenes 7,000 2,662 1,718
Raten ICN在国际... 中的贡献 对太空旅行的核推进的承诺和挑战 Koivunoro-1：硼中子捕获疗法中的治疗计划和剂量计算 NASA对太空核裂变技术的投资 回旋基础知识
Focus on the development of the LFR demonstrator (technical and economic viability) ALFRED Demonstrator, 125 MWe, connected to grid Evolution : • 2011, Romania expressed the interest to host ALFRED • 2013, FALCON international consortium set-up • 2014, nuclear platform Mioveni as reference site • 2018, RATEN ICN notified the regulatory body on the pre-licensing phase • 2020, starting the construction of相关许可和RDI基础架构
Bonney Lake Bess Coober Pedy Reenwable Hybrid Project V2G电力市场建模报告 KS6 - SPP1操作报告
This Report is for general information only and the Iberdrola Entities, their related entities and their respective directors, officers, employees, agents, consultants and contractors do not accept, and expressly disclaim, any liability whatsoever (including for negligence or negligent misstatement) for any loss or damage suffered or incurred arising out of, or in connection with (i) the information, statements, opinions, recommendations and other matters expressed or （ii）本报告中包含的任何遗漏，以及（iii）使用本报告或依赖此处包含的信息的任何遗漏。
分子标记
PCR based genetic markers : RAPD (Random Amplified Polymorphic DNA), AFLP (Amplified Fragment Length Polymorphism), SSR (Simple Sequence Repeat), STR (Single Tendem Repeats), VNTR (Variable Number Tendem Repeat), STS (Sequence Tag Size), SNP (Single Nucleotide Polymorphism), EST (Expressed Sequence Tagged) Hybridization based遗传标记：RFLP（限制片段长度多态性）分子标记也可以分类为 -