本演示文稿包含有关未来结果,绩效和成就的前瞻性陈述,这些陈述受风险和不确定性的影响,并反映了由可用信息形成的管理层的观点和假设。历史事实陈述以外的所有陈述都是可以认为是前瞻性陈述的陈述。在此文档中使用时,诸如“预期”,“相信”,“估计”,“期望”,“打算”,“五月”,“计划”,“项目”或“应该”和类似表达式(与佳能相关的表达)之类的词,旨在识别前瞻性陈述。Many factors could cause the actual results, performance or achievements of Canon to be materially different from any future results, performance or achievements that may be expressed or implied by such forward-looking statements, including, among others, changes in general economic and business conditions, changes in currency exchange rates and interest rates, introduction of competing products by other companies, lack of acceptance of new products or services by Canon's targeted customers, inability to meet efficiency and cost reduction objectives, changes in business strategy and various其他因素,均在本演讲中引用和未引用。应实现一个或多个风险或不确定性,或者基本假设证明不正确,实际结果可能与本文所述的结果有很大不同。佳能不打算或承担更新这些前瞻性语句的任何义务。
本演示文稿包含有关未来结果,绩效和成就的前瞻性陈述,这些陈述受风险和不确定性的影响,并反映了由可用信息形成的管理层的观点和假设。历史事实陈述以外的所有陈述都是可以认为是前瞻性陈述的陈述。在此文档中使用时,诸如“预期”,“相信”,“估计”,“期望”,“打算”,“五月”,“计划”,“项目”或“应该”和类似表达式(与佳能相关的表达)之类的词,旨在识别前瞻性陈述。Many factors could cause the actual results, performance or achievements of Canon to be materially different from any future results, performance or achievements that may be expressed or implied by such forward-looking statements, including, among others, changes in general economic and business conditions, changes in currency exchange rates and interest rates, introduction of competing products by other companies, lack of acceptance of new products or services by Canon's targeted customers, inability to meet efficiency and cost reduction objectives, changes in business strategy and various其他因素,均在本演讲中引用和未引用。应实现一个或多个风险或不确定性,或者基本假设证明不正确,实际结果可能与本文所述的结果有很大不同。佳能不打算或承担更新这些前瞻性语句的任何义务。
ABSTRACT Background: Delayed diagnosis and inadequate treatment caused by limited biomarkers are associated with the outcomes of COVID-19 patients.有必要确定其他有希望的生物标志物和候选靶标,以定义失调的炎症状态。Methods: The triggering receptors expressed on myeloid cell (TREM)-1 and TREM-2 expression from hospitalized COVID-19 patients were characterized using ELISA and flow cytometry, respectively.评估了它们与疾病严重程度的相关性,并与主要的临床指标进行了对比。结果:与对照组相比,发现Covid-19患者血浆中可溶性TREM-1和TREM-2的表达增加。Moreover, membrane-bound TREM-1 and TREM-2 expression was upregulated on the cell surface of circulating blood T cells from COVID-19 patients.Correlation analysis showed that sTREM-2 levels were negatively correlated with PaO 2 /FiO 2 , but positively correlated with C-reactive protein (CRP), procalcitonin (PCT) and interleukin (IL)-6 levels.Receiver operating characteristic curve analysis indicated that the predictive efficacy of sTREM-1 and sTREM-2 was equivalent to CRP and IL-6, and a little better than absolute leukocyte or neutrophil count and PCT in distinguishing disease severity.Conclusion: TREM-2 and TREM-1 are critical host immune factors that response to SARS-COV-2 infection and could serve as potential diagnostic biomarkers and therapeutic targets for COVID-19.
saf港声明:本新闻稿中的某些陈述是前瞻性陈述。在某些情况下,我们已经通过“可能会导致”,“有信心”,“期望”,“期望”,“应该”,“可以”,“可能”,“”,“相信”,“相信”,“相信”,“预测”,“预测”,“预测”,“预测”,“估计”项目,“”项目,“”“”“”“”“”,“”“”“”“”,“”项目, 1995年《私人证券诉讼改革法》的含义中的“前瞻性陈述”,包括这些单词和短语的否定。这种前瞻性陈述基于我们有关未来事件,未来业务状况以及基于当前可用信息的Arcadium锂的前景的当前观点和假设。There are important factors that could cause Arcadium Lithium's actual results, level of activity, performance or achievements to differ materially from the results, level of activity, performance or achievements expressed or implied by the forward-looking statements, including the factors described under the caption entitled "Risk Factors" in Arcadium Lithium's 2023 Form 10-K filed with the Securities and Exchange Commission ("SEC") on February 29, 2024, as以及Arcadium锂的其他SEC文件和公共通讯。尽管Arcadium Lithium认为前瞻性陈述中反映出的期望是合理的,但Arcadium锂不能保证未来的结果,活动水平,绩效或成就。此外,Arcadium锂和任何其他人都不承担这些前瞻性陈述的准确性和完整性的责任。Arcadium Lithium无权在此新闻发布之日更新这些前瞻性陈述,以使其先前的陈述符合实际结果或经过修订的期望。
本演示文稿包含有关未来结果,绩效和成就的前瞻性陈述,这些陈述受风险和不确定性的影响,并反映了由可用信息形成的管理层的观点和假设。历史事实陈述以外的所有陈述都是可以认为是前瞻性陈述的陈述。在此文档中使用时,诸如“预期”,“相信”,“估计”,“期望”,“打算”,“五月”,“计划”,“项目”或“应该”和类似表达式(与佳能相关的表达)之类的词,旨在识别前瞻性陈述。Many factors could cause the actual results, performance or achievements of Canon to be materially different from any future results, performance or achievements that may be expressed or implied by such forward-looking statements, including, among others, changes in general economic and business conditions, changes in currency exchange rates and interest rates, introduction of competing products by other companies, lack of acceptance of new products or services by Canon's targeted customers, inability to meet efficiency and cost reduction objectives, changes in business strategy and various其他因素,均在本演讲中引用和未引用。应实现一个或多个风险或不确定性,或者基本假设证明不正确,实际结果可能与本文所述的结果有很大不同。佳能不打算或承担更新这些前瞻性语句的任何义务。
本演示文稿包含有关未来结果,绩效和成就的前瞻性陈述,这些陈述受风险和不确定性的影响,并反映了由可用信息形成的管理层的观点和假设。历史事实陈述以外的所有陈述都是可以认为是前瞻性陈述的陈述。在此文档中使用时,诸如“预期”,“相信”,“估计”,“期望”,“打算”,“五月”,“计划”,“项目”或“应该”和类似表达式(与佳能相关的表达)之类的词,旨在识别前瞻性陈述。Many factors could cause the actual results, performance or achievements of Canon to be materially different from any future results, performance or achievements that may be expressed or implied by such forward-looking statements, including, among others, changes in general economic and business conditions, changes in currency exchange rates and interest rates, introduction of competing products by other companies, lack of acceptance of new products or services by Canon's targeted customers, inability to meet efficiency and cost reduction objectives, changes in business strategy and various其他因素,均在本演讲中引用和未引用。应实现一个或多个风险或不确定性,或者基本假设证明不正确,实际结果可能与本文所述的结果有很大不同。佳能不打算或承担更新这些前瞻性语句的任何义务。
本演示文稿包含有关布里斯托尔美犬公司(“公司”)未来财务业绩,计划,业务发展策略,预期临床试验,结果和监管部门批准的陈述,这些临床试验,结果和监管部门构成了前瞻性陈述,构成了《安全港规定》,《私人证券诉讼改革法案》,1995年的《私人证券诉讼改革法》。所有不是历史事实陈述的陈述都是或可能被认为是前瞻性陈述。Actual results may differ materially from those expressed in, or implied by, these statements as a result of various factors, including, but not limited to, (i) new laws and regulations, (ii) our ability to obtain, protect, and maintain market exclusivity rights and enforce patents and other intellectual property rights, (iii) our ability to achieve expected clinical, regulatory and contractual milestones on expected timelines or at all, (iv) difficulties or delays in the development以及新产品的商业化,(v)在我们的临床试验以及产品的制造,分销和销售中的困难或延迟,(vi)法律或监管程序中的不利结果,(VII)风险与收购,划分,联盟,联盟,合资风险,合资企业和其他投资组合行动以及(VIII和财务状况)的风险有关这些和其他重要因素在公司的最新年度报告中进行了10-K的最新报告,以及有关表格10-Q和8-K的报告。这些文件可在美国证券交易委员会的网站,公司的网站或Bristol-Myers Squibb投资者关系中找到。无法保证前瞻性语句。
该药物会受到其他监测。这将允许快速识别新的安全信息。医疗保健专业人员被要求报告任何可疑的不良反应。有关如何报告不良反应的第4.8节。1。药物产物的名称Incellipan悬浮液在预填充的注射器大流行性流感疫苗(H5N1)(表面抗原,灭活,佐剂,佐剂,在细胞培养物中制备)。2。QUALITATIVE AND QUANTITATIVE COMPOSITION Influenza virus surface antigens (haemagglutinin and neuraminidase), inactivated, of strain*: A/turkey/Turkey/1/2005 (H5N1)-like strain (NIBRG-23) 7.5 micrograms** per 0.5 ml dose * propagated in Madin Darby Canine Kidney (MDCK) cells ** expressed in微克血凝素。Adjuvant MF59C.1 containing per 0.5 ml dose: squalene 9.75 milligrams polysorbate 80 1.175 milligrams sorbitan trioleate 1.175 milligrams sodium citrate 0.66 milligrams citric acid 0.04 milligrams This vaccine complies with the WHO recommendations and EU decision in an officially declared pandemic situation.incellipan可能包含β-丙二醇,多溶棒80和氯铵溴化物的痕量残留物,这些残留物在制造过程中使用(请参阅第4.3节)。有关赋形剂的完整列表,请参见第6.1节。3。注射药物悬浮液(注射)。乳白色悬架。4。临床细节4.1治疗指示Incellipan在官方宣布的大流行中进行了主动免疫对流感的主动免疫。应根据官方建议使用Incellipan。4.2六个月大的成年人和儿童的职位和行政方法
摘要。紧密连接(TJ)是细胞连接的重要组成部分;它们保持细胞极性,渗透性和粘附,并参与细胞增殖和分化的调节。Claudin(CLDN)家族是TJ不可或缺的一部分,Cldn6是该家族的重要成员。CLDN6的异常表达可以通过各种机制破坏TJ的完整性,并且可以在肿瘤的发生和发育中起多种作用。 cldn6在各种肿瘤中广泛表达,但在健康的成年组织中很少表达。 本综述的目的是批判性地检查有关CLDN6的最新文献,包括其结构,不同肿瘤中的表达,调节机制和治疗前景。 尽管某些结论是有争议的,但在某些肿瘤中,例如肝脏,卵巢,子宫内膜和食管癌,以及非典型的致畸形/牙龈肿瘤,但研究始终表明CLDN6在肿瘤组织中表达,但在周围组织中不表达或在低水平的组织中表达。 在这些肿瘤中,CLDN6具有癌胚抗原和治疗靶标的潜力。CLDN6的异常表达可以通过各种机制破坏TJ的完整性,并且可以在肿瘤的发生和发育中起多种作用。cldn6在各种肿瘤中广泛表达,但在健康的成年组织中很少表达。本综述的目的是批判性地检查有关CLDN6的最新文献,包括其结构,不同肿瘤中的表达,调节机制和治疗前景。尽管某些结论是有争议的,但在某些肿瘤中,例如肝脏,卵巢,子宫内膜和食管癌,以及非典型的致畸形/牙龈肿瘤,但研究始终表明CLDN6在肿瘤组织中表达,但在周围组织中不表达或在低水平的组织中表达。在这些肿瘤中,CLDN6具有癌胚抗原和治疗靶标的潜力。
