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新型 HPV 疫苗和更少剂量：消除宫颈癌的有希望的最新进展（IARC 证据摘要第 4 号）
2023 年 4 月 21 日 新型 HPV 疫苗和更少剂量：消除宫颈癌的有希望的最新进展（IARC 证据摘要第 4 号）
单雇主定义的福利计划精算信息
at-risk status for fewer than five consecutive years and disregarding loading factor ........................................... 4b -123456789012345 5 Effective interest rate ............................................................................................................................................ 5 123.12 % 6 Target normal cost ................................................................................................................................................ a Present value of current plan year accruals ....................................................................................................... 6a b Expected plan-related expenses ....................................................................................................................... 6b c Total (line 6a + line 6b) ..................................................................................................................................... 6c
超过30多个汽车品牌计划返回2024年加拿大
There will be no fewer than 30 automotive brands on the main show floors of the AutoShow in the North and South buildings of the Metro Toronto Convention Centre, Returning from the 2023 AutoShow are Buick, Cadillac, Chevrolet, Chrysler, Dodge, Fiat, GMC, Hyundai, Jeep, Kia, Lexus, Nissan, Ram, Subaru, Tesla, Toyota, Vinfast和Wagoneer，与保时捷，福特，林肯，Infiniti，Polestar，Volvo和Genesis一起，将他们的最新车辆和创新带回了多伦多，以获得2024年的Autoshow。此外，还将是Bentley，Rolls Royce，Lamborghini，Aston Martin，Pinifarina和Bugatti等几个奢侈品牌。
美国森林加尔关于区域连通性的研究
•在东盟的大量能源部门投资和经济增长。到2050年： - 年度研发投资20亿美元。- 累计发电能力投资1.4万亿美元。- 通过改善发电，资源优化和降低的发电成本来发展的本地行业发展。– Regional clean energy supply chain • 2000-9000 direct annual jobs created • Reduced electricity costs regionally by 3-3.9% • Increased GDP by 0.8-4.6% per country • Reduced financial risk and increases energy access • Improved system reliability and resilience to weather event • Reduce particulate air pollution for 99% of population by average of 50% , leading to 15,000 fewer pollution-induced deaths annually
成本管理白皮书
卓越中心（COE）是临床上卓越，具有成本效益的医疗保健中心网络，这些网络有助于管理复杂的医疗状况，包括癌症和先天性心脏病，以及减肥，新生儿和移植需求。Having access to these kinds of curated networks is important when an employee or their family member is dealing with a complex condition, since COEs are built to enable: • More accurate diagnoses and fewer readmissions and complications • Reduced initial procedure costs and a simplified billing and payment experience • Higher survival rates and better outcomes • Care orchestrated by condition experts who regularly work together • Appropriate therapy — neither too much nor too little
NHOA宣布其c。€2.5亿欧元的权利发行NHOA宣布其c。€2.5亿欧元的权利发行
状态。As a result, the securities may and have been offered in any Relevant State only (i) to qualified investors within the meaning of the Prospectus Regulation, for any investor in a Member State of the European Economic Area, or Regulation (EU) 2017/1129 as part of national law under the European Union (Withdrawal) Act 2018 (the “ UK Prospectus Regulation ”), for any investor in the United Kingdom, (ii) to fewer than 150 individuals or legal entities （除了招股说明书法规或英国招股说明书法规所定义的合格投资者外，（iii）或（iii）根据招股说明书法规的第1（4）条所规定的豁免，或其他任何其他条件下不需要根据expectus prospectus法规的第3条规定的NHOA出版的任何其他情况下，该法规规定的规定，或/或适用于/或/或探险。
r e v i e w的发展和关节内注射治疗的前景：评论
摘要：骨关节炎（OA）是一种常见的退化性疾病，影响了绝大多数老年人，最终可能踏上了总膝关节置换术（TKA）的道路，尽管在医学界仍然存在有关骨关节炎最佳疗法的医学界。Compared with physical therapy, oral analgesics and other non-operative treatments, intra-articular injection is more safe and effective.Moreover, intra-articular injection is much less invasive and has fewer adverse reactions than surgical treatment.本文回顾了皮质类固醇（CS），透明质酸（HA），富含血小板的血浆（PRP），间充质干细胞（MSC），基质血管分数（SVF）（SVF）和其他新疗法（例如：基因治疗）的机制，益处和不良反应。The application prospect of intra-articular injection was analyzed according to the recent progress in drug research.Keywords: osteoarthritis, intra-articular injection, treatment, prospect, review
河岸树在气候危机中的韧性 - 碳
摘要 - 人类的生命是短暂的，而Cauvery是永恒的。随着行星由于人为作用而应对气候紧急情况，Cauvery River Basin（CRB）的河岸树作为重要的监护人，其重要的蛋白质用于隔离碳。这项研究强调了使用基于地面的非破坏性方法依属于CRB保护区的Talakaveri和Muthathi旅游场所中河岸树的碳固执潜力。Talakaveri, situated in Talakaveri Wildlife Sanctuary, neighbouring the Brahmagiri Wildlife Sanctuary witness diverse range of riparian tree species demonstrating significant carbon sequestration potential, whereas Muthathi despite harbouring fewer riparian tree species exhibit higher carbon sequestration potential primarily attributed tothe presence of Terminalia arjuna (Roxb.)Wight＆Arn。，CRB中的Keystone物种。这项研究揭示了河岸树在CRB内的碳封存中的关键作用，因此成为减轻气候危机并保护河流遗产的希望的灯塔。
疫苗不足儿童母亲的疫苗犹豫的患病率和预测因素：基于医院的横断面研究
结果：在574名受访者中，有161个母亲的孩子被认为是疫苗固化的（拒绝= 7；延迟= 154）；疫苗犹豫的患病率为28.05％。在所有推荐的疫苗中都观察到了延迟，但是仅在四种疫苗中看到拒绝或不情愿（丙型肝炎出生剂量= 1； IPV 1和2 = 2；麻疹1和2 = 3；以及rota 1、2和3 = 1）。The respondents' demographics like no or lower parent education (OR = 3.17; 95%CI = 1.50–6.72) and fewer antenatal visits (OR = 2.30; 95%CI = 1.45–3.36) showed higher odds, whereas the upper socioeconomic status showed lower odds (OR = 0.09; 95%CI = 0.02–0.36) toward vaccine hesitancy.The WHO– SAGE dimensions like awareness (OR = 0.14; 95%CI = 0.03–0.53), poor access (OR = 7.76; 95%CI = 3.65–16.51), and low acceptability of the individual (OR = 07.15; 95%CI = 1.87–27.29), community (OR = 6.21; 95%CI = 1.58–24.33）与疫苗犹豫显着相关。
胸腔手术后增强四倍的健康结果：可行性飞行员使用数字家庭监控
背景：出院后的手术恢复通常给患者和看护人带来挑战。术后并发症和在家管理不良的疼痛可能会导致对急诊科（ED）的意外访问和去医院的再入院。数字家庭监控（DHM）可以改善术后护理。目的：与标准护理相比，我们进行了一项随机对照试验（RCT）的可行性研究，以评估胸外科手术后的DHM有效性。方法：我们在单个三级护理中心进行了2臂平行组飞行员RCT。接受胸腔手术程序的成年患者被随机分为2组：DHM组和护理标准（对照组）。我们遵守了意向性治疗分析原则。主要结果是预先确定的RCT可行性标准。如果超过75％的试验募集，协议依从性和数据收集，则该试验将是可行的。次要结果包括30天的ED访问率，30天的再入院率，术后并发症，住院时间长度，30天阿片类药物消费量，30天的恢复质量，患者培训质量满意度，照料者满意度，医疗保健提供者满意度以及每例案例成本。结果：满足所有RCT可行性标准。试验招聘率为87.9％（95％CI 79.4％-93.8％）。协议依从性和结果数据收集率分别为96.3％（95％CI 89.4％-99.2％）和98.7％（95％CI 92.9％-99.9％）。总共有80名患者被随机分配，DHM组为40例（50％），对照组40例（50％）。基线患者和临床特征在两组之间是可比的。The DHM group had fewer unplanned ED visits (2.7% vs 20.5%; P =.02), fewer unplanned admission rates (0% vs 7.6%; P =.24), lower rates of postoperative complications (20% vs 47.5%, P =.01) shorter hospital stays (4.0 vs 6.9 days; P =.05), but more opioid consumption （111.6，SD 110.9）vs 74.3，SD 71.9 mg吗啡等效物；与对照组相比，p = .08）。DHM also resulted in shorter ED visit times (130, SD 0 vs 1048, SD 1093 minutes; P =.48) and lower cost per case (CAD $12,145 [US $ 8436.34], SD CAD $8779 [US $ 6098.20] vs CAD $17,247 [US $11,980.37], SD