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成功的学术研究需要好奇心，创造力和愿意去证据领导的地方。这些项目体现了这种努力。These projects are the fruits of sustained and meaningful collaboration with faculty and fellow students and are often the capstone of a baccalaureate or master's degree program.Many of these projects are informed by and through community partnerships that serve to enrich the scholarship, research and creative activity of our students and faculty.These partnerships are critical to strengthening our institutional mission of fostering civic responsibility, addressing societal issues and contributing to the public good.
财务健康行动计划|麦哲伦医疗保健
人生的梦或目标：您的人生梦想，人生目标或愿望是什么？This is usually something that truly matters to us in one of the wellness dimensions: • social (meaningful relationships, sense of belonging), • physical (good nutrition, health, activity), • occupational (well-paying work, purposeful career), • intellectual (knowledge and creativity), • environmental (safe and decent housing, neighborhood, other environments), • emotional (experiencing joy, coping well with life's challenges), and • spiritual (feeling目的，含义）。对我们来说重要的是与我们的身份，我们的价值，我们的文化和身份密切相关。在阐明了您的人生梦或愿望之后，请写下为什么这对您和您的身份很重要。
![数据（使用和访问）帐单[HL] - （修订论文）](/simg/a\ae3f5f9aacc596eac0b1c0c85f5e319253198d61.webp)
数据（使用和访问）帐单[HL] - （修订论文）
(b) mechanisms for ensuring meaningful participant control and governance over shared datasets, (c) potential incentives for organisations to participate in or develop such data trusts, (d) safeguards to protect individuals' rights and freedoms when data is shared, (e) requirements for transparency in data trusts' decision-making, including governance arrangements and any commercial partnerships, (f) arrangements for ongoing independent oversight and review, and (g) an assessment这些模型如何在健康，气候弹性和能源等社会有益领域中推动创新，经济增长和数据驱动的研究。
Zolbetuximab注射（Vyloy）
来自2个随机，双遮盖的，安慰剂对照的III期试验（Spotlight and Glow）的证据表明，Zolbetuximab添加到氟吡啶丁胺 - 和铂的化学疗法中时（改良的氟尿嘧啶加氟尿嘧啶加上白细胞素的改性，以及对OXALIPPATIN 6 [MFOLFOLFOFFOOX 6]或CAPECITIPLAT []或CAPECITIPLAT []或CAPECITIPLATIN []或CAPECALIPLATIN []患有局部晚期不可切除或转移性HER2-阴性胃癌或GEJ腺癌的患者具有CLDN18.2阳性的肿瘤患者，从而增加了临床益处。The SPOTLIGHT trial (N = 565) demonstrated that treatment with zolbetuximab in combination with mFOLFOX6 resulted in statistically significant and clinically meaningful improvements in overall survival (OS) (hazard ratio [HR] = 0.784; 95% confidence interval [CI], 0.644 to 0.954; P = 0.0075) and progression-free survival (PFS) (HR = 0.751;与安慰剂结合使用MFOLFOX6，CI，0.598至0.942；The GLOW trial (N = 507) similarly demonstrated that treatment with zolbetuximab in combination with CAPOX resulted in statistically significant and clinically important meaningful improvements in OS (HR = 0.763; 95% CI, 0.622 to 0.936; P = 0.0047) and PFS (HR = 0.687; 95% CI, 0.544 to 0.866; P = 0.0007),与安慰剂与Capox结合使用相比。在关键试验中，与单独的化学疗法相比，用化学疗法结合使用Zolbetuximab与化学疗法结合使用，与恶心，呕吐和输注相关的反应的风险增加有关。但是，PERC与临床专家一致，这些不良事件（AES）在临床实践中可能是可以管理的。
epcoritamab（epkinly）
Evidence from 1 ongoing phase I/II open-label, single-arm study (EPCORE NHL-1, which included 157 patients with r/r LBCL) suggested that treatment with epcoritamab may result in clinically meaningful improvements in median overall survival (OS) (OS = 18.5 months; 95% confidence interval [CI], 11.7 to |||| ) and progression-free survival (PFS) (PFS = 4.4个月; 95％CI，3.0至8.8）。在12个月时对OS和PFS进行其他里程碑分析|||| |||||| ||| ||||||和18个月|||| |||||| ||| ||||||支持生存分析。epcoritamab与|||||的临床有意义的完整响应（CR）相关联||| ||| ||| || |||||和持久的响应（响应的中值持续时间[dor] = ||| ||||||; 95％CI，9.7 to |||||）。EPCORE NHL-1研究的结果表明，与健康相关的生活质量（HRQOL）没有损害。
Cadth报销建议
Evidence from one open-label phase III randomized controlled trial involving a total of 886 patients with locally advanced or metastatic urothelial cancer (Study EV-302) showed that treatment with enfortumab vedotin in combination with pembrolizumab demonstrated a clinically meaningful benefit compared to platinum plus gemcitabine chemotherapy (PLAT + GEM) in improving overall survival (HR: 0.468 [95% CI: 0.376，0.582]; p <0.00001），无进展生存率（HR = 0.450，95％CI：0.377，0.538; p <0.00001）和客观响应率（差异= 23.3％[95％CI，16.8％至29.6％]；Enfortumab Vedotin与Pembrolizumab结合使用的安全性与Enfortumab Vedotin单一疗法和pembrolizumab单一疗法的已知安全概况一致。
December 10, 2024 - Medicine Minute - Lazarte Receives Service Award | Staff Members Take on New Roles | Residents Match into Fellowship Programs
Obesity is a chronic complex disease defined by excessive fat deposits that can impair health. The cardiorenal metabolic syndrome, which includes obesity, diabetes, cardiovascular disease, chronic kidney disease and fatty liver disease, is a target of GLP-1 receptor and/or GIPR incretin-based therapies. These drugs, tirzepatide (sold under the brand names Mounjaro and Zepbound) and semaglutide (sold under the brand names Ozempic, Rybelsus, and Wegovy), are now widely used for weight loss and diabetes, and as such, offer a hopeful avenue to treat obesity and its related diseases. Researchers at UT Southwestern have shown the GIP receptor (GIPR), a protein in fat cells, is a meaningful target for the development of future incretin-based therapeutic interventions for treating obesity and its associated metabolic diseases.
新闻稿，2025年1月21日，韩国授予Diamyd Medical的Precision Medicine in Autommune Diabetes
1st-line benefit in combination with widely approved CDK4/6 inhibitors Positive high-level results from a planned interim analysis of the SERENA-6 Phase III trial showed that AstraZeneca's camizestrant in combination with a cyclin-dependent kinase (CDK) 4/6 inhibitor (palbociclib, ribociclib or abemaciclib) demonstrated a highly statistically significant and clinically meaningful无进展生存期（PFS）的主要终点的改善。该试验评估了切换到芳香酶抑制剂（AI）（ANASTROZOLE或LETROOZOLE）与CDK4/6抑制剂在一线治疗激素受体（HR）患者（HR）蛋白（HR） - 蛋白蛋白酶（Her2）型乳腺较大较大的癌症中的一线治疗中，与CDK4/6抑制剂结合使用了CDK4/6抑制剂，将切换到持续的护理标准治疗。
Respecting Rights in Renewable Energy
• Global modern slavery regulation, which fails to adequately compel companies to remove products made with the use of forced labour from their supply chains, exacerbates this issue. The notable exception to this is the US Uyghur Forced Labor Prevention Act (UFLPA), which applies a rebuttable presumption that any product mined, produced or manufactured, wholly or in part, in the Uyghur Region is tainted by forced labour and consequently cannot be imported into the US. Many of the investors we approached noted that the UFLPA was the primary incentive for meaningful investor action. Companies operating in jurisdictions without import controls or comparable legislation have little material incentive to undertake the labour-intensive work of supply chain tracing and thus are less proactive in addressing portfolio exposure.
Adam D. Pazda
使用并被视为性信号。在A. Columbus（编辑），《心理学研究进展》，第89卷。Hauppauge，纽约：Nova。 Grants (*denotes student collaborator) SC Research Foundation, Magellan ($2,460) 2024 The black clothing effect and perceptions of aggression: Impacts of gender and skin color *Chloe Powell & Adam Pazda USC Aiken Center for Research Excellence, Connections ($680) 2024 Examining the degree to which experiencing awe influences perceptions of living a meaningful life *Emma Leopard &南卡罗来纳大学的亚当·帕兹达（Adam Pazda）上升（6,000美元）2023社交媒体使用使用会预测具有回避社交目标的人的抑郁和焦虑社交媒体的使用如何缓和心理需求满意度 *Madeline Riggins和Adam Pazda USC Aiken Aiken卓越研究中心，联系（925美元）2022探索社交方法/避免，主动/被动社交媒体的使用以及性别如何预测福利 *Hauppauge，纽约：Nova。Grants (*denotes student collaborator) SC Research Foundation, Magellan ($2,460) 2024 The black clothing effect and perceptions of aggression: Impacts of gender and skin color *Chloe Powell & Adam Pazda USC Aiken Center for Research Excellence, Connections ($680) 2024 Examining the degree to which experiencing awe influences perceptions of living a meaningful life *Emma Leopard &南卡罗来纳大学的亚当·帕兹达（Adam Pazda）上升（6,000美元）2023社交媒体使用使用会预测具有回避社交目标的人的抑郁和焦虑社交媒体的使用如何缓和心理需求满意度 *Madeline Riggins和Adam Pazda USC Aiken Aiken卓越研究中心，联系（925美元）2022探索社交方法/避免，主动/被动社交媒体的使用以及性别如何预测福利 *