amiodarone,Canagliflozin,Daclatasvir,Flibanserin,Flecainide,prazosin,prapafenone,propafenone,Quinidine,螺丝酮,大花生酸酯,大花环抗生素,例如。erythromycin and clarythromycin, tetracycline (and possibly other antibiotics), gentamicin, isavuconazole, itraconazole, ivacaftor, quinine, trimethoprim, alprazolam, indomethacin, propantheline, mirabegron, nefazodone, atorvastatin, ciclosporine, epoprostenol (transient), vasopressin receptor antagonists (tolvaptan and conivaptan), carvedilol, ritonavir/ritonavir containing regimens, taleprevir, dronedarone, ranolazine, simeprevir, telmisartan, lapatinib, ticagrelor, vandetanib, velpatasvir, venetoclax and vemurafenib。。血清高辛浓度应受到监测并用于滴定地高辛。
amiodarone amitriptyline(Elavil)atomoxetine(Stattera)阿奇罗霉素(Zithromax)氯喹(Aralen)氯丙嗪(Aralen)氯丙嗪氯普噻吩(三分)ciprofrofloofloofloofloofloofloofloofloofloofloofloporam(celexa)Clarithromycin(Cellithromycin)(Clarithromycin)(dislromencin)(Clarithromycin)(dipolycyrmodycyramidemidpyramidemidemidemetramidemidemidemidemidemidemetramide) Domperidone doxepin dronedarone(Multaq)droderidol ronythromycin(cipralex)氟卡因酯(Tambocor)氟康唑Gatifloxacin(Tequin)Haloperidol(haldol)(haldol)haldol)(haldol)hydroxychoroquine(plaquine)(plaquine)(plaqury)(corvertrome)(corvertrome) Maprotiline Methadone (Metadol) Mexiletine Moxifloxacin (Avelox) Ondansetron (Zofran) Oxaliplatin ( Eloxatin ) Papaverine HCl Pentamidine Pimozide Procainamide Propafenone (Rythmol) Propoxyphene Propofol ( Diprivan, Provoven ) Quinidine Saquinavir (Invirase) Sotalol trazodone Vandetanib(Caprelsa)
右美沙芬由 CYP2D6 代谢,具有广泛的首过代谢。同时使用强效 CYP2D6 酶抑制剂可使体内右美沙芬浓度增至正常水平的数倍。这会增加患者发生右美沙芬毒性作用(激动、精神错乱、震颤、失眠、腹泻和呼吸抑制)和患上血清素综合征的风险。强效 CYP2D6 酶抑制剂包括氟西汀、帕罗西汀、奎尼丁和特比萘芬。与奎尼丁同时使用时,右美沙芬的血浆浓度会增加高达 20 倍,这会增加该药物对中枢神经系统的不良影响。胺碘酮、氟卡宁和普罗帕酮、舍曲林、安非他酮、美沙酮、西那卡塞、氟哌啶醇、奋乃静和硫利达嗪对右美沙芬代谢也有类似的影响。如果必须同时使用 CYP2D6 抑制剂和右美沙芬,则应对患者进行监测,并可能需要减少右美沙芬的剂量。
Alpha 1 -adrenoreceptor antagonist: alfuzosin Antianginal: ranolazine Antiarrhythmic: dronedarone, propafenone, quinidine Anticancer drugs: neratinib, venetoclax Anti-gout: colchicine Antihistamines: terfenadine 抗精神病药/神经疗法:lurasidone,pimozide,Quetiapine良性前列腺增生性增生产品:硅氧脂蛋白心血管药物产品:eplerenone,eplerenone,ivabradineERGOT衍生物ERGOT衍生物:Dihydrogogotinal,Ergotanion,Ergioner ofergoterine:e氧素,甲基甲基辅助物质: cisapride Immunosuppressants: voclosporin Lipid-modifying agents: o HMG Co-A reductase inhibitors: lovastatin, simvastatin o Microsomal triglyceride transfer protein (MTTP) inhibitor: lomitapide Migraine medicinal products: eletriptan Mineralocorticoid receptor antagonists: finerenone 阿片类药物拮抗剂:NaloxegolPDE5抑制剂:Avanafil,Sildenafil,Tadalafil,Vardenafil镇静剂/催眠药:氯唑培训,白二爱,白唑仑,雌唑仑,氟他莎草,氟西唑仑,咪达唑仑和甲状腺酸唑仑和Triazopress•vastapaptin•divapapt
lapatinib和cyp3a4诱导剂(如地塞米松,苯二苯甲状腺肿,甲状腺素,甲状腺素,rifampin,rifabin、rifabutin,rifapentin rifapentin,苯巴比妥phemobitaline s s. st. st. st. st. st. st. john’s wert)克至每日5500毫克。corchicine:↑秋水仙碱血浆浓度和秋水仙碱毒性的风险增加。⚫羟氯喹,德罗纳酮,氟康唑,伏立康唑,奥心肽,氟喹诺酮类酮,多奈哌啶,丙咪吡啶,氟哌啶醇,舍氏甲酸,氯丙氨酸,氯丙氨酸,氯丙烷,Quetiapine,Quetiapine,Quetiapine,Quetiapine,sulpiride,sulpiride,prochlorazine,pro -proplanishisone,quanansonnon of quansetron,on qunand forsetron,quand forsetron,qund fornoude;间隔延长。⚫酮康唑:↑拉帕替尼暴露或血浆浓度。 carbamazepine,圣约翰麦芽汁:↓拉帕替尼暴露或血浆浓度。 怀:⚫酮康唑:↑拉帕替尼暴露或血浆浓度。carbamazepine,圣约翰麦芽汁:↓拉帕替尼暴露或血浆浓度。怀:
答:将成员考虑在后续行动中挥舞着旋转的曲折:1。Eliglustate1(GIC,CERDLE)或2。Tetrabean2(例如,Xenacine)或3。mptaminiary3。amptaminiary 3。amptaminiary 3(adzenys,adzenys,ampespel),ampespel),dyanakes,dyanakes,dyokes,diipp nipp and a vepes,4 (Eech,Aristoted)或6。Atomooxetine6(道德)或7。Brexpopprazle7(Ethat,Rexult)或8。Clospox)或8。Clozine8(for,for,for,for,fast。9Trabbencies 9(g Oxydine 12(Othing,Lightyra),或13。Meclass13。13。14。Mechlopramids14(道德,Reglan,Metozolv)或15。油15(伦理,Ollinvyk)或16. Small 16(Small 16) IP,Ultrami)或21。Valley21(GIC,工程师)或22。Venlafaxine22(Ethice,Efxeer)或23。Vorthox23。23。23。