(%)所见的住院患者比例(<30%)60 75 75 75 80胰岛素N/A 86 80 86的患者比例在DKA/HHS N/A 100 95 100的患者中,患者的比例在DFD N/A 97 95 100降低了胰岛素给药的患者中(22%)15 9 12 7 12 7 12 7 12 7降低了DFD N/A 97 95的患者比例。 (27%)14 5 5 0
1。引言不可凝聚的气体(NCG)是所有地热系统中都存在的天然气体,从世界各种系统的各种系统中的小到大的质量分数(<0.1 wt%至> 3 wt%> 3 wt%,代表NCGS在整个储层中使用NCGS的比例,在本文中使用了这一定义)。二氧化碳(CO 2)通常主导着NCG化妆品,但其他气体(例如硫化氢(H 2 S),甲烷(CH 4)和其他气体经常存在。The quantity and the relative proportion of each NCG gas is primarily driven as a function of geology, of magma type/heat source, and subsurface stratigraphy that fluids encounter (Fridriksson et al, 2017).作为排放,NCG的释放可能会不利,包括对温室气体排放,空气质量和环境危害的贡献(Richardson and Webbison,2024年)。然而,在自流动(自流式)生产井中,NCG可以通过提高可交付性来使生产受益:井对自流到给定的井口压力的能力。重新注射NCG既可以抵消排放的负面影响,又可以延长交付性益处。
Urothelial carcinoma (UC) originates from the urothelial lining renal pelvis, ureter, bladder, and urethra. Based on the report from Global Cancer Statistics 2020, bladder cancer is the 7th and 13th most frequent malignancy among men worldwide and those in Japan, respectively (1,2). Unresectable, metastatic, or advanced UC (aUC) is a progressive, poor prognostic disease with a median overall survival (OS) time of approximately 19–26 months following first-line (1L) platinum-based chemotherapy and subsequent administration of immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies (3-6). A substantial proportion of the population responds poorly to chemotherapy and ICIs, resulting in poor survival outcomes. Novel upfront drug combinations including ICIs, antibody-drug conjugates, and tyrosine kinase inhibitors (TKIs) are currently being tested in an attempt to overcome drug resistance and improve antitumor activity.
表1:胸部X射线发现的三种优先策略中AI系统的性能指标,包括灵敏度,特异性,正预测值(PPV)和负预测值(NPV)。ppv:阳性预测价值 - 真正阳性的AI阳性病例的比例。npv:负预测价值 - 真正负面因素的AI阴性案例的比例。fpr:误报率 - AI标记的非癌症案件的比例。fnr:假阴性率 - AI错过的癌症病例的比例。
表32。Schedule of Events - Screening, Baseline, and Treatment Period – Visits 1 through 14* ......................................................................................................................................................87 Table 33.事件时间表 - 治疗期限续。- 访问15至27* .........................................................................................................................................................................................................................................................................................................................................................................................................................................................活动时间表 - 后续行动,外观访问和提前终止*............................................................................................................................................................................................................................. 91表35。Initial (16-week) Treatment Period Subject Disposition for Trial 1224*.......................95 Table 36.Summary of Subject Accountability and Study Disposition – All Randomized Subjects* ......................................................................................................................................................96 Table 37.Summary of Major Protocol Deviations – All Randomized Patients*...........................98 Table 38.Baseline Demographics for Trial 1224* ........................................................................99 Table 39.Baseline Disease Severity for Trial 1224* ...................................................................100 Table 40.Medical History Findings (≥5% of Patients in Any Treatment Group) by Primary System Organ Class and Preferred Term– SAF*......................................................................................101 Table 41.Atopic/Allergic Disease History – SAF* .......................................................................102 Table 42.Compliance with Background Moisturizer (Emollient)* .............................................103 Table 43.Rescue Medication Taken during the 16-Week Period – SAF*...................................105 Table 44.Rescue Medication Taken during the 52-Week Period*.............................................106 Table 45.在第16周联合试验中获得治疗成功的受试者的比例1224*.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................在第16周* ...............................................................................................................................................................................................................从基线到第16周的峰值每日瘙痒率≥4的每周峰值平均每周平均每周的受试者比例(减少)*...............................................................................................................................................................................................................Proportion of Subjects with at least 4-point change from baseline Weeks 2, 4, 16 for Trial 1224*..................................................................................................................................109 Table 49.Proportion of Subjects with IGA success(1) at Week 52 among those that were IGA responders(1) at Week 16 for Trial 1224*..................................................................................109 Table 50.Success on the IGA at Week 16 by Baseline IGA Severity for Trial 1224*...................110 Table 51.在研究第16周实现治疗成功的受试者的比例1224*... 112表55。效力(IgA 0或1)通过基线人口统计学研究1334和1416*..................................................................................................................................... 113表56。Proportion of Subjects Achieving Treatment Success at Week 16 for Monotherapy Studies 1334, 1416* ...................................................................................................................111 Table 52.Proportion of Subjects Achieving Treatment Success at Week 16 for Combination Study 1224*................................................................................................................................111 Table 53.Proportion of Subjects Achieving Treatment Success at Week 16 for Monotherapy Studies 1334, 1416* ...................................................................................................................112 Table 54.效力(IgA 0或1)通过基线人口统计学的试验1224*。IgA响应者由基线IgA严重程度1334和1416*........................................................................................................................................................................................................................................................................................................................................................................................................................................................... 114表58。研究在第16周的IGA成功,基线IgA严重程度研究1224*.............................................................................................................................................................................................................................................................................................................................................................................................................................................Efficacy Results of DUPIXENT Monotherapy at Week 16 (FAS) ..................................119 Table 60.Efficacy Results of DUPIXENT with Concomitant TCS a at Week 16.............................120 Table 61.按研究编号按样本量 - 初级安全池 - (所有注册受试者)*......... 123
5.2.1:过去 12 个月内,遭受现任或前任亲密伴侣实施的身体、性或心理暴力的 15 岁及以上有伴侣妇女和女童的比例,按暴力形式和年龄分列 5.2.2:过去 12 个月内,遭受非亲密伴侣实施的性暴力的 15 岁及以上妇女和女童的比例,按年龄和发生地点分列 16.1.3:过去 12 个月内遭受(a)身体暴力、(b)心理暴力和/或(c)性暴力的人口比例 16.2.3:18 岁前遭受过性暴力的 18-29 岁年轻女性和男性比例 16.3.1:过去 12 个月内遭受(a)身体暴力、(b)心理暴力和/或(c)性暴力的受害者中,向主管当局或其他官方认可的冲突解决机制报告受害情况的比例 0.g.负责全球监测的国际组织
吉普斯兰岛所有六个地方政府地区的代表性分布变化。参与量最高的LGA是Latrobe City,占总体35%,而Gippsland受访者中有37%比估计的25%的地区人口比例高约32.4%。同样,与吉普斯兰人口的估计比例相比,低音海岸郡的调查参与率高约33%。Baw Baw Shire和East Gippsland Shire的参与度较低,而估计人口比例的比例分别分别为44.4%和45.9%。LGA参与最不成比例的LGA是惠灵顿郡,调查参与比其总吉普斯兰总人口的估计比例低两倍。南吉普斯兰郡(South Gippsland Shire)在吉普斯兰(Gippsland)集水区的六个LGA的调查参与最为比例。南吉普斯兰郡(South Gippsland Shire)在吉普斯兰(Gippsland)集水区的六个LGA的调查参与最为比例。
红色粗体数据表示该比例明显低于其他受访者,相反,绿色粗体数据表示该比例明显高于其他受访者。
1.2021/2139 号授权条例附件 I 和 II 第 4.26 节中提到的分类法一致的经济活动的数量和比例,在适用的 KPI 分母中 a) 基于营业额 0 0 0 0 n/a n/a b) 基于资本支出 0 0 0 0 0 0 2.2021/2139 号授权条例附件 I 和 II 第 4.27 节中提到的分类法一致的经济活动的数量和比例,在适用的 KPI 分母中 a) 基于营业额 0 0 0 0 n/a n/a b) 基于资本支出 1 0 1 0 0 0 3.第 4.28 节中提到的分类法一致的经济活动的数量和比例授权条例 2021/2139 附件 I 和 II 中适用 KPI 分母中的金额 a) 基于营业额 5 0.1 5 0.1 不适用 不适用 b) 基于资本支出 8 0.2 8 0.2 0 0 4.授权条例 2021/2139 附件 I 和 II 第 4.29 节中提及的分类法相关经济活动的数量和比例,以适用 KPI 分母中的金额 a) 基于营业额 0 0 0 0 不适用 不适用 b) 基于资本支出 0 0 不适用 不适用 0 0 5.授权条例 2021/2139 附件 I 和 II 第 4.30 节中提及的分类法相关经济活动的数量和比例,以适用 KPI 分母中的金额适用 KPI 的分母 a) 基于营业额 0 0 0 0 n/a n/a b) 基于资本支出 0 0 0 0 0 0 6.适用 KPI 的分母中上述第 1 至第 6 行未提及的其他分类法相关经济活动的数量和比例 a) 基于营业额 0 0 0 0 n/a n/a b) 基于资本支出 0 0 0 0 0 0 7.适用 KPI 的分母中上述第 1 至第 6 行未提及的其他分类法相关经济活动的数量和比例 a) 基于营业额 51 1.2 51 1.2 0 0 b) 基于资本支出 64 1.6 64 1.6 0 0 8.适用 KPI 总计 a) 基于营业额 4 104 100 4 104 100 4 104 100 b) 基于资本支出 4 104 100 4 104 100 4 104 100
