ABSTRACT: Gallium phosphide (GaP) is a III − V semiconductor with remarkable optoelectronic properties, and it has almost the same lattice constant as silicon (Si). However, to date, the monolithic and large-scale integration of GaP devices with silicon remains challenging. In this study, we present a nanoheteroepitaxy approach using gas-source molecular-beam epitaxy for selective growth of GaP islands on Si nanotips, which were fabricated using complementary metal − oxide semiconductor (CMOS) technology on a 200 mm n-type Si(001) wafer. Our results show that GaP islands with sizes on the order of hundreds of nanometers can be successfully grown on CMOS-compatible wafers. These islands exhibit a zinc-blende phase and possess optoelectronic properties similar to those of a high-quality epitaxial GaP layer. This result marks a notable advancement in the seamless integration of GaP- based devices with high scalability into Si nanotechnology and integrated optoelectronics. ■ INTRODUCTION
Rest of the World (estimated 2024) 4.395 123.646 119.251 4.328 115.185 110.857 Total 45.213 1.097.051 1.051.838 41.739 974.604 932.865 WWEA President Dr. Irfan Mirza: The first half of 2024 has showcased remarkable progress in the global wind energy sector.在十二个月中增加了123吉瓦的新容量,我们现在处于开创性的里程碑的门槛-1,2 terawatt按年底按安装风能的能力。这些成就不仅强调了我们行业的韧性,而且还强调了其在推动全球能源过渡中必不可少的作用。风能是一种强大的独立清洁能源来源,同时还可以补充其他可再生解决方案,以建立多功能和可持续的能源未来。它的灵活性使其成为应对全球能源和气候挑战的基石。在WWEA,我们仍然坚定地致力于支持我们的会员并促进合作,以加快全球可再生能源部署。本报告证明了继续在可持续未来的社区,政府和企业的集体努力。让我们以这种势头为基础,并共同努力,以确保风能的增长有益于所有人类。
Abstract: Advances in molecular tumor diagnostics have transformed cancer care. However, it remains unclear whether precision oncology has the same impact and transformative nature across all malignancies. We conducted a retrospective analysis of patients with human papillomavirus (HPV)-related gynecologic malignancies who underwent comprehensive molecular profiling and subsequent discussion at the interdisciplinary Molecular Tumor Board (MTB) of the University Hospital, LMU Munich, between 11/2017 and 06/2022. We identified a total cohort of 31 patients diagnosed with cervical (CC), vaginal or vulvar cancer. Twenty-two patients (fraction: 0.71) harbored at least one mutation. Fifteen patients (0.48) had an actionable mutation and fourteen (0.45) received a recommendation for a targeted treatment within the MTB. One CC patient received a biomarker- guided treatment recommended by the MTB and achieved stable disease on the mTOR inhibitor temsirolimus for eight months. Factors leading to non-adherence to MTB recommendations in other patient cases included informed patient refusal, rapid deterioration, stable disease, or use of alternative targeted but biomarker-agnostic treatments such as antibody–drug conjugates or checkpoint inhibitors. Despite a remarkable rate of actionable mutations in HPV-related gynecologic malignancies at our institution, immediate implementation of biomarker-guided targeted treatment recommendations remained low, and access to targeted treatment options after MTB discussion remained a major challenge.
本研究论文探讨了古代印第安人做出的显着科学贡献,涵盖了数千年的时期。从最早的吠陀时期到古普塔帝国,印度文明在各种科学领域都取得了显着进步,包括数学,天文学,医学和冶金学。本文强调了古代印度科学家的关键成就,其工作的持久影响以及他们留给后代的丰富知识分子遗产。我们国家丰富的遗产包括大量的古老科学知识,这些知识主要塑造了世界。从天文学和数学到医学和冶金学,很久以前生活的科学家做出了突破性的发现并设计出了非凡的理论。他们的智慧和见解继续激发和影响我们对世界的理解。
过去十年见证了机器学习(ML)方法的越来越多,包括物理科学在内[1]。The rise of deep learning (DL) [ 2 ] in early 2010 and the remarkable potential of deep neural networks (DNNs) in learning highly predictive models, mainly powered by convolutional [ 3 ] and recurrent [ 4 ] neural networks, emphasized with the ImageNet challenge [ 5 ] and developments in areas such as reinforcement learning [ 6 ], have boosted the application of artificial intelligence (AI) in nearly all domains and thus reshaped the AI的未来。DL革命之后是成功的变压器体系结构[7],其中“注意”的概念被添加到标准NN的体系结构中,以捕获数据特征之间的长期相关性。变形金刚是大语言模型(LLM)的基础,可以通过在大型数据集上预处理,从而在没有特定领域的知识的情况下学习上下文,从而解开了另一个AI的新时代。尽管AI的发展急剧发展,但大多数基于ML的物理科学应用程序[1]着重于学习非线性数值模型以完成特定任务(例如,数据分析,模拟等)实现新发现。这里出现了物理学家对应用ML的期望以及如何推进物理学的期望。只是一组革命性的数学工具,其性能克服了经典方法,从而取代了它们(例如,DL表现出色的促进决策树,用于针对事件选择任务,该任务针对粒子物理学的标准模型以外的理论[8]),或者是数据驱动的科学发现的能力[8])?
具有富含镍的阴极的锂金属电池(LMB)是下一代高能密度电池的有前途的候选者,但是缺乏能力保护性的电极/电解质相互作用(EEIS)限制了其周围性。在此,提出了三氧基苯苯作为局部浓缩离子液体电解质(LCILES)的助理,以增强EEIS。通过对纯离离子液体电解质(ILE)和三个使用纤维苯,三甲基苯基苯或三氧基苯苯的比较研究电导率和功能,以及通过调节1-乙基-3-甲基咪唑醛酸阳离子(EMIM +)和BIS(FuroSulfonyl)酰亚胺阴离子的贡献,EEIS的组成。Trifluoromethoxybenzene, as the optimal cosolvent, leads to a stable cycling of LMBs employing 5 mAh cm − 2 lithium metal anodes (LMAs), 21 mg cm − 2 LiNi 0.8 Co 0.15 Al 0.05 (NCA) cathodes, and 4.2 μ L mAh − 1 electrolytes for 150 cycles with a remarkable capacity retention 71%,这要归功于LMA上富含无机物种的固体电解质相,尤其是富含EMIM +衍生物种的NCA阴极上的均匀阴极/电解质相间。相比之下,在相同条件下的容量保留率分别仅为16%,46%和18%,而基于氟苯和苯并二烯氟化物的LCLE分别为16%,46%和18%。
JOINT MEDIA STATEMENT 1. The Fifty-Sixth ASEAN Economic Ministers (AEM) Meeting was held in Vientiane, Lao PDR on 17 September 2024. The Meeting, which was chaired by Lao PDR under the theme “Enhancing Connectivity and Resilience” was preceded by a preparatory meeting of the ASEAN Senior Economic Officials (SEOM) and joint meetings with the 38 th ASEAN Free Trade Area (AFTA) Council and the 27 th ASEAN Investment Area (AIA) Council. Responding to Regional and Global Developments 2. The Meeting was encouraged by the sustained growth momentum across the region which, despite broader challenges facing the global economy, has shown remarkable resilience over the past two years. The Meeting noted that ASEAN continues to shine as a bright spot in the global economy in 2024, with prospects outpacing the global outlook. 3. The Meeting reiterated ASEAN's unwavering commitment to regional economic integration, acknowledging the formidable challenges posed by global economic fragmentation, heightened geopolitical tensions, and the increasingly stringent trade regulations related to decarbonisation. The Meeting recognized that the ASEAN economy expanded by 4.1 in 2023 and is projected to experience a robust growth of 4.6% in 2024 and 4.7% in 2025. The growth is expected to be driven by a solid improvement in both domestic and external demand. 1 The resurgence in key sectors such as semiconductors and electronics are the main catalysts to the resurgence in the overall demand 2 . The Meeting emphasized ASEAN's focus on promoting transformative sectors, such as the digital and green economy, to reinforce ASEAN's position as the epicenter of growth.
Marine invertebrate stem cells (MISCs) represent a distinct category of pluripotent and totipotent cells with remarkable abilities for self-renewal and differentiation into multiple germ layers, akin to their vertebrate counterparts.这些独特的细胞在整个生物体的成年生活中持续存在,并且在各种成年海洋无脊椎动物门中都被观察到。MISC在许多生物学过程中起着至关重要的作用,包括针对海洋无脊椎动物的发育生物学现象,例如衰老,延迟衰老,全身再生和无性繁殖。此外,它们是研究干细胞生物学的宝贵模型。尽管有很大的能力,但有关MISC的信息仍然很少,并且在科学文献中散布了。在这篇综述中,我们通过阅读研究和检测各种海洋无脊椎动物生物中的MISC的文章,仔细地收集并汇总了有关杂项检测的有价值信息。审查开始于定义杂项并突出与脊椎动物相比的独特特征。然后,它讨论了无脊椎动物和脊椎动物研究中使用的杂项检测和体外技术的共同标记。这项全面的综述为研究人员和科学家提供了有关海洋无脊椎动物生物中的MISC特征,检测方法和相关生物学现象的凝聚和简洁概述。我们旨在为对海洋无脊椎动物干细胞感兴趣的研究人员和科学家提供宝贵的资源,从而更好地理解其对生物学的广泛意义。随着科学技术的持续进步和对海洋无脊椎动物物种的持续探索,我们预计进一步的发现将扩大我们对MISC的知识及其对生物学的广泛意义。