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levemir®Flexpen®（胰岛素detemir（rys））解决方案...
胰岛素dletemir在血浆中与蛋白质结合的97％，而与性别无关。The results of in vitro studies do not suggest any clinically relevant albumin binding interactions between insulin detemir and fatty acids or other protein-bounds drugs (such as warfarin, frusemide, tolbutamide, diazepam, glibenclamide, nicardipine, repaglinide, aspirin or valproic acid) or other drugs known to bind to domains IIA and IIIA of the albumin molecule.由于每个胰岛素detemir分子的血浆中可用的白蛋白结合位点（约40万）过量（约400 000），因此很少有风险较低的白蛋白浓度较低，因此某些疾病状态（例如肾病综合征）（例如肾病综合征）可能会影响与游离胰岛素detemir或可能发生这种急性移位的比例。这得到了体外研究以及临床试验计划的亚组分析的支持。尽管如此，严重低藻症患者的数据有限。
Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death
The quest for targeted therapies is critical in the battle against cancer. The RAS/ MAP kinase pathway is frequently implicated in neoplasia, with ERK playing a crucial role as the most distal kinase in the RAS signaling cascade. Our previous research demonstrated that the interaction between ERK and MYD88, an adaptor protein in innate immunity, is crucial for RAS-dependent transforma- tion and cancer cell survival. In this study, we examine the biological con- sequences of disrupting the ERK-MYD88 interaction through the ERK D-recruitment site (DRS), while preserving ERK ' s kinase activity. Our results indicate that EI-52, a small-molecule benzimidazole targeting ERK-MYD88 interaction induces an HRI-mediated integrated stress response (ISR), resulting in immunogenic apoptosis speci fi c to cancer cells. Additionally, EI-52 exhibits anti-tumor ef fi cacy in patient-derived tumors and induces an anti-tumor T cell response in mice in vivo. These fi ndings suggest that inhibiting the ERK-MYD88 interaction may be a promising therapeutic approach in cancer treatment.
撤回 - 重新训练通道到降低 - pdf
该报告似乎主要使用文献中的一项饮食变化研究，并不当地使用它，以得出这样的结论：饮食变化对减少气候排放的贡献非常小（约为2-5％）。通过将可持续的饮食变化与全国推荐的饮食混为一谈，并使用不透明和不正确的方法与数据不完整的数据来得出这一结论。结果可能会给人一种错误的印象，即减少肉类消耗的减轻排放潜力是有限的，因此，牲畜的强化应该是主要的，即使不是排他性的目标。While the FAO's incorrect estimates suggest that dietary change can contribute only 0.19-0.53 Gt CO 2 eq ⋅ a −1 , researchers in Science found an opportunity of 3.10 Gt CO 2 eq ⋅ a −1 using robust and appropriate modeling (increasing to 6.22 Gt CO 2 eq ⋅ a −1 if the land that is spared is used to draw down carbon) 1 .这在IPCC汇总的较早估计的范围内：0.7-8 GT CO 2 eq·A -1。
PNC SEMINARS - Padova Neuroscience Center
The wiring of the nervous system follows a complex genetic plan during development. However, due to stochastic processes and environmental factors, genetically identical individuals seldom show the same phenotypic outcome. In poikilothermic animals like insects, temperature affects developmental speed, but whether this alters brain wiring and function was so far unclear. We have investigated the effect of temperature on brain wiring in Drosophila, showing that neuronal connectivity scales exponentially with temperature, with lower connectivity at higher temperatures. To explain this finding, we extended the metabolic theory of ecology to model the coordination between body and brain development. The theory predicts a temporal shift between body and brain development, which we have validated experimentally. Physiological analysis suggest that temperature-induced changes in brain wiring have circuit-specific consequences for function. We conclude that while some circuit computations are robust to the effects of developmental temperature on wiring, others exhibit phenotypic plasticity with possible adaptive advantages.
气候改变地理的新方向
摘要此评论反映了人类地理对气候变化研究的贡献，以及对气候变化的人类地理工作的未来方向。我建议该领域的关键成就之一是使气候变化一个边界对象：一个实体，其解释性的挠性性允许它成为一个共同的知识对象，原则上可以促进跨不同实践社区的协作。但是，该贡献的方式并成为可能，其在其他地方的影响。While the subfield of political ecology and its historiographical methods have played vital roles in laying the intellectual foundations for human geographic work on climate change, and thus its ability to construct climate change as a boundary object in the first place, I suggest that they and other neo- Marxian approaches to the study of the (climate- changing) environment tend to diminish human geographic engagement with the future as an object of scholarly inquiry.要解决这一限制并有助于将气候变化的地理在新颖的方向上推动，我建议气候变化的期货从事问题。i然后以讨论关键的经验领域的讨论（主体的克利姆特赔偿和气候适应）进行了讨论。
霉酚酸莫菲蒂在免疫管理中 -
•霉酚酸酯莫夫蒂尔是一种有效的，选择性的，不竞争的和可逆的肌苷一磷酸脱氢酶（IMPDH）的抑制剂，这又导致抑制鸟苷核苷酸核苷酸合成的从头途径。t-和b淋巴细胞增殖取决于该途径，因此霉酚酸酯莫菲蒂是淋巴细胞增殖的有效抑制剂。霉酚酸酯莫菲蒂一直用于急性同种异体移植排斥。Off licence it has been used as a steroid sparing agent for the treatment of rheumatic diseases and to treat immune-related adverse events (irAEs) from treatment with checkpoint inhibitors, most commonly IR-hepatitis • The ESMO guidelines suggest the use of mycophenolate as a steroid sparing agent in immune mediated hepatitis, interstitial lung disease, rheumatological toxicity,神经肌肉毒性和心肌炎。在这些条件下，有关于霉酚酸酯使用的案例报告。也用于类固醇难治性疾病•该文件旨在用作专着，以提供开处方和监测建议后，一旦决定启动霉酚酸酯莫菲蒂。这不是临床指南，而是用于伊拉斯时使用霉酚酸酯莫弗蒂尔的共识观点。应与任何本地政策/程序/准则一起使用，并应根据信托临床治理流程批准使用。
全基因组关联研究研究谷物蛋白，千核重量和面包小麦（Triticum aestivum L.）的归一化差异指数
摘要：研究谷物蛋白含量（GPC），1000个核重量（TKW）和归一化差异植被指数（NDVI）的基因组区域，以280种面包小麦类型类型进行了研究。使用35K公理阵列对全基因组关联（GWAS）面板进行了基因分型，并在三个环境中进行了表型。在覆盖面包小麦的A，B和D亚基因组的18个染色体上检测到总共26个标记性属性关联（MTA）。GPC显示最大MTA（16），其次是NDVI（6）和TKW（4）。最多10 mTA位于B亚基因组上，而在A和D亚基因组上映射了8个MTA。In silico analysis suggest that the SNPs were located on important putative candidate genes such as NAC domain superfamily, zinc finger RING-H2-type, aspartic peptidase domain, folylpolyglutamate syn- thase, serine/threonine-protein kinase LRK10, pentatricopeptide repeat, protein kinase-like domain superfamily,细胞色素P450和扩张蛋白。发现这些候选基因具有不同的作用，包括调节胁迫耐受性，养分重液，蛋白质积累，氮利用率，光合作用，谷物填充，线粒体功能和核心发育。新鉴定的MTA的影响将在不同的遗传背景中得到验证，以进一步利用标记育种。
i西波利斯塔卫生卫生大会
224。多态性-579G＆＃8594; DNA基因甲基转移酶3B（DNMT3B）的T和降低Patricia y Barbosa综合征1,2的母亲风险； Cristiani C Mendes 2; Bruna L Zampieri 2; Joice M Biselli 2； ENY M GOLONI-BERTOLLO 2; ÉrikaCPavarino 2 1 Famerp Medicine课程的学术课程； 2 FAMERP FAMPING MOLECULAR RESEARCH AND BIOLOGY (UPGEM) RESEARCH UNIT: PIBIC - CNPq/FAMERP Introduction: Down syndrome (SD) is more frequent human chromosomopathy and studies suggest that the occurrence of this syndrome, regardless of maternal age, is related to DNA hypomethylation as a consequence of abnormal metabolism of the foolate.这种代谢途径负责S-腺苷（SAM）的合成，这是DNA甲基化反应最大的甲基甲基供体。甲基转移酶（DNMTS）酶催化甲基转移，DNMT3B基因中的多态性会影响DNMT3B酶活性对DNA甲基化的活性。目的：研究多态性DNMT3B -579G＆＃8594; t是SD的产妇风险因素。方法：将评估90个患有SD（病例组）和100名没有综合征儿童（对照组）的女性的母亲。多态性DNMT3B -579G的分子分析＆＃8594; t将通过实时通过聚合酶链反应（PCR）的艾莉卡歧视技术进行。数据将通过测试最大似然比，物流回归和卡方检验来分析数据。预期结果：预计将确定多态性DNMT3B -579G＆＃8594; t在孕产妇对SD的风险。
新的生物化学专业
LECTURES BIOSC # Course Name Pre-req Cr 1070 Honors Human Physiology BIOSC 0160 + CHEM 0120 3 1120 Biostatistics STAT 1000 3 1130 Evolution BIOSC 0350 3 1250 Human Physiology BIOSC 0160 + CHEM 0120 3 1275 Genomics BIOSC 0350 3 1280 Microbial Genetics BIOSC 0350 + 1850 3 1455 Human Endocrinology BIOSC 1250 3 1500 Cell Biology BIOSC 1000 or 1810 3 1520 Developmental Biology BIOSC 0350 3 1540 Computational Biology BIOSC 0160 3 1730 Virology BIOSC 0350 + 1000/1810 + 1850 3 1760 Immunology BIOSC 0350, suggest 1000/1810 3 1850 Microbiology BIOSC 0160 3 1865 Microbial Physiology BIOSC 0350 + 1000/1810 3 1945 Advance分子生物学BIOSC 1940 3 CHEM 1830合成生物学BIOSC 1000或1810 3 LABS BIOSC＃课程名称Pre-Req CR 0351 Genetics Lab biosc 006X，（C）0350 1 0352 MOREC简介。遗传学实验室BIOSC 006X，0350 1 1285基因组实验室BIOSC 006X，0350 1 1290微生物遗传学实验室（C）BIOSC 1850; BIOSC 006X 1 1510细胞生物学实验室BIOSC 006X，（C）1500 1 1530发育生物实验室BIOSC 006X，（C）1520 1 1855 Microbiology Lab Biosc 006X介绍，（C）1850 1
脑科学
摘要：由于中风患者的个体间变异性很高，中风结果的预测是具有挑战性的。我们最近提出了对大脑储备概念（BR）的改编，以改善中风结果的预测。这个概念最初是与一个用于神经变性的认知储备一起开发的，并形成了一个有价值的理论框架，以捕获中风患者的高个体间变异性。In the present work, we suggest and discuss (i) BR- proxies—quantitative brain characteristics at the time stroke occurs (e.g., brain volume, hippocampus volume), and (ii) proxies of brain pathology reducing BR (e.g., brain atrophy, severity of white matter hyperintensities), parameters easily available from a routine MRI examination that might improve the prediction of stroke outcome.尽管这些参数对中风结果的影响已被部分报道，但它们的独立和综合影响尚未确定。从概念上讲，BR是一项连续的措施，确定可用于减轻和补偿中风损害的大脑结构的数量，从而反映了神经资源的个体差异以及在中风后保持性能和恢复的能力。我们建议中风结果可以定义为当时中风和病变负荷之间的BR之间的相互作用。中风中的BR可能会受到改变心血管危险因素的影响。除了BR概念的潜在力量在对中风结果中个体间变异性的机械理解和建立个性化的治疗方法中，它还可能有助于增强中风，神经变性和健康衰老的预防措施的协同作用。