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Sail66正在开发CLDN6阳性固体癌症
A prominent academic journal in the field of cancer immunotherapy has adopted the non-clinical research results of SAIL66, which uses the Dual-Ig technology, a unique antibody engineering technology made by Chugai Pharmaceutical, Non-clinical research suggests that SAIL66 has high selectivity for CLDN6 (claudin 6), and that it may exhibit a higher antitumor effect compared to conventional T-cell engagers by costimulating CD3和CD137目前，正在对CLDN6阳性固体癌
美国首次投资 - 信号 - 高探调 -
NSPM借鉴了各种两党支持的各种建议，其中包括现任国务卿马可·卢比奥（Marco Rubio）在参议院任职期间提出的许多提案，以及其他由中国众议院选择委员会成员提出的。Although its direction to CFIUS to restrict Chinese investments in sensitive sectors largely aligns with how CFIUS currently assesses such transactions, the NSPM suggests that CFIUS may pare back its use of mitigation agreements — especially with investors from U.S. partners and allies — which had dramatically increased in recent years, in what may be an implicit recognition that CFIUS' more frequent use of these agreements in reviews of investments from partners盟友可能对大量良性外国投资产生了令人不寒而栗的影响。
神经元功能障碍和基因调节帕金森氏病和突触核酸的非编码RNA
Over the last few decades, emerging evidence suggests that non-coding RNAs (ncRNAs) including long-non-coding RNA (lncRNA), microRNA (miRNA) and circular-RNA (circRNA) contribute to the molecular events underlying progressive neuronal degeneration, and a plethora of ncRNAs have been identified significantly misregulated in many神经退行性疾病，包括帕金森氏病和突触性疾病。尽管在许多情况下尚未清楚地确定神经病理学与致病候选者之间的直接联系，但NCRNA对导致神经退行性疾病中细胞功能障碍的分子过程的贡献已经解决，这表明它们可能在这些疾病的病理学中起作用。本综述的目的是概述和讨论最近的文献，这些文献涉及帕金森病和突触核苷模型中神经病理学不同方面的基于RNA的机制的作用。
策略到支持 - 竞争性批评性 -
Vibrant Clean Energy's modeling of a regional transmission organization (RTO) in the Southeast United States suggests that introducing competition and regional optimization into electric grid planning, operations, and regulation can have significant benefits to customers– saving 29 percent on electricity costs and reducing emissions 37 percent below 2018 levels by 2040.，它还将通过增加最小成本清洁能源项目的近130（GW）来创造新的经济发展机会，并创造数十万个新工作机会，足以远远超过损失的煤炭和天然气工作。随着清洁能源的资源将昂贵的化石发电厂从系统中推开，东南客户将看到较低的电力速度，清洁的空气，减少的碳排放以及通过清洁能源部署的大量就业增长。
源自riluzole的新型萘基取代的氨基硫唑防止颞叶癫痫大鼠模型中的急性神经兴奋性损伤
结果：当在KA之前进行施用时，SKA-378（30mg/kg）并不能阻止癫痫持续状态（SE），但在3D后仍能阻止海马和其他边缘区域的神经损伤。在KA诱导的SE后1小时给予SKA-379，SKA-378，SKA-377，SKA-41或RILUZOLE时，也会减弱易受伤害的海马兴奋性（CA3/CA1）的神经损伤和抑制（HIRAR）神经元的神经元。对SKA-378和Riluzoles在体外运输阻滞的动力学分析表明，抑制是通过非竞争性的间接机制发生的。While sodium channel NaV1.6 antagonism blocks activity-regulated MeAIB transport and SKA- 378 is the most potent inhibitor of NaV1.6 (IC50=20µM) compared to NaV1.2 (IC50=118µM) in vitro , pharmacokinetic analysis suggests sodium channel blockade may not be the predominant mechanism of neuroprotection by these compounds in vivo .
对曾经每天达拉非的处方的位置声明...
•在SWL中不支持他每天（特别是低剂量）的Tadalafil处方。分配平板电脑无牌使用，不建议使用。•审查每天开出的tadalafil/cialis®规定的现有患者，如果按照通常的指导在临床上进行治疗，则更改为每周/PRN tadalafil。•在任何新患者中不要每天开始一次达拉非2。• Choose the PDE-5 inhibitor with the lowest acquisition cost (currently generic sildenafil) as the evidence suggests that sildenafil, tadalafil and vardenafil have similar efficacy in treating ED 2,3,4,5 • If previous PDE-5 inhibitor on-demand treatment has not been satisfactorily effective, consider: o If the patient received relevant counselling advice on appropriate use of PDE-5抑制剂3。o患者是否知道PDE-5抑制剂需要性刺激才能工作3。o如果患者以最大剂量接受了6-8剂的PDE-5抑制剂
抑郁症和冠心病：机制，干预和治疗
冠心病（CHD）是一种对人类健康和生命构成重大威胁的心血管疾病，对世界造成了巨大的经济负担。然而，与常规的危险因素相比，抑郁症成为冠心病的新型和独立的危险因素。这种情况会影响冠心病的发作和进展，并提高已经受CHD影响的人的不良心血管预后事件的风险。结果，抑郁症引起了全球关注的越来越多。尽管人们的意识越来越不断提高，但抑郁症促进冠心病发展的特定机制仍不清楚。Existing research suggests that depression primarily in fl uences the in fl ammatory response, Hypothalamic- pituitary-adrenocortical axis (HPA) and Autonomic Nervous System (ANS) dysfunction, platelet activation, endothelial dysfunction, lipid metabolism disorders, and genetics, all of which play pivotal roles in CHD development.此外，抗抑郁病患者抗抑郁治疗的有效性和安全性及其对冠心病患者预后的潜在影响已成为有争议的受试者。有必要进行进一步的调查，以解决这些尚未解决的问题。
免疫原性细胞死亡诱导剂在癌症免疫治疗中的临床应用：让冷肿瘤变热
Immunotherapy has emerged as a promising cancer treatment option in recent years. In immune “ hot ” tumors, characterized by abundant immune cell in fi ltration, immunotherapy can improve patients ' prognosis by activating the function of immune cells. By contrast, immune “ cold ” tumors are often less sensitive to immunotherapy owing to low immunogenicity of tumor cells, an immune inhibitory tumor microenvironment, and a series of immune-escape mechanisms. Immunogenic cell death (ICD) is a promising cellular process to facilitate the transformation of immune “ cold ” tumors to immune “ hot ” tumors by eliciting innate and adaptive immune responses through the release of (or exposure to) damage-related molecular patterns. Accumulating evidence suggests that various traditional therapies can induce ICD, including chemotherapy, targeted therapy, radiotherapy, and photodynamic therapy. In this review, we summarize the biological mechanisms and hallmarks of ICD and introduce some newly discovered and technologically innovative inducers that activate the immune system at the molecular level. Furthermore, we also discuss the clinical applications of combing ICD inducers with cancer immunotherapy. This review will provide valuable insights into the future development of ICD- related combination therapeutics and potential management for “ cold ” tumors.
新闻稿Valby，2024年3月5日Lundbeck提出了LU AF82422试验的令人鼓舞的结果
Press release Valby, 5 March 2024 Lundbeck presents encouraging results from the Lu AF82422 trial for Multiple System Atrophy at the international AD/PD 2024 conference on neurodegenerative disorders The AMULET trial strengthens the case for Lundbeck's Lu AF82422, as initial clinical data suggests that the anti-alpha-synuclein monoclonal antibody (mAb) has a潜力减慢临床进展。H. lundbeck A/S（Lundbeck）在AFAF82422的双盲阶段宣布了临床数据。演示文稿将从下午4:35开始。lu af82422是一种人类单克隆抗体（MAB），识别并结合了所有主要形式的细胞外α-核蛋白，因此据信可以防止摄取和抑制聚集的播种。lu AF82422可以通过靶向MSA的潜在疾病病理并旨在减缓临床进展，从而提供潜在的治疗选择。基于令人鼓舞的护身符试验成果，伦德贝克计划在与卫生当局进行进一步对话后启动III期研究。“我们很高兴能提供数据，该数据可以推进解决重大未满足需求的可能选择。我们期待进一步了解该计划对MSA患者的利益的潜力。lundbeck的科学演示，AD/PD 2024
中央银行对印度储备银行的洞察力的物理气候风险的处理
日益增加对气候变化影响的全球认可导致中央银行，金融当局及其协会，以评估受监管实体（RES）的物理气候风险暴露的原则，准则和方法论方法。______________________________________________________ Practical experience from selected central banks suggests a phased approach with clear timelines to implement physical climate risk assessment policies.这种方法允许在政策制定的早期阶段提高对气候问题的积极意识，提高监管期望以及范围内的技术能力和数据可用性。在实施阶段，大多数新兴市场中央银行认为采用比例原则，以表彰技术能力的差异和RES的系统性重要性。__________________________________________________中央银行指出，关于数据可用性，建模风险和不同能力的RES的挑战。在这种情况下，当前的政策努力旨在增强重新管理物理气候风险的能力，而不是修改资本要求。______________________________________________________ The Reserve Bank of India (RBI) has taken critical steps to raise awareness among REs on climate issues, and it is important not to lose this momentum.本文根据基于分阶段的方法提供了风格化的路线图，并采用了RBI可能会考虑的实用步骤，以制定雄心勃勃的时间表，以进行气候分析，压力测试和披露要求。