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2025; 21（4）：1730-1748。 doi：10.7150/ijbs.105575研究论文二硫兰兰/铜/铜触发CGAS-sting先天免疫途径通过ROS诱导的DNA Dama
免疫检查点阻滞（ICB）已成为治疗晚期恶性肿瘤的主要策略；但是，它们的临床功效通常受到原发性或获得性抗性的限制。利用先天免疫信号传导增加淋巴细胞浸润到肿瘤中已被认为是一种增强抗癌免疫反应的有希望的方法。二硫仑（DSF）是一种用于慢性酒精中毒的FDA批准的药物，已显示出有效的抗肿瘤作用，尤其是与铜（CU）结合使用时。在这里，我们证明了DSF和CU（DSF/CU）的组合处理，可牢固地激活癌细胞中的CGAS-CGAS-sting依赖性的先天免疫信号通路。进一步的研究表明，DSF/CU通过诱导过量的活性氧（ROS）产生而引起线粒体和核DNA损伤以及胞质DSDNA的释放，从而触发先天的免疫力并增强抗肿瘤作用。此外，DSF/CU显着提高了CD8 +细胞毒性淋巴细胞和天然杀伤（NK）细胞的肿瘤内浸润，并增强了鼠类肿瘤模型中PD-1检查点阻断的治疗效果。总体而言，我们的发现提供了DSF/CU的抗癌和免疫调节功能的基本原理，并突出了重新利用DSF的潜力，以改善癌症患者对ICB的反应。
Patrick T. Garcia，美国种子监管事务负责人 野生肠慢性浪费疾病管理和反应活动2024合作协议2024项目执行摘要
帕特里克·T·加西亚（Patrick T.Box 7062 Johnston, IA 50131 RSR number 24-172-01rsr RE: Regulatory Status Review of corn developed using genetic engineering for expression of a resistance (R) protein that recognizes effector protein secreted by Setosphaeria turcica and signals a hypersensitive response that destroys infected tissue through programmed cell death, expression of a wall-associated kinase protein that triggers检测到setosphaeria turcica后的下游免疫反应，非典型模式识别受体（PRR）蛋白的表达，只有一个富含亮氨酸的重复区域，可触发下游免疫反应，在检测到L型晶状体酶蛋白蛋白蛋白蛋白蛋白蛋白蛋白蛋白蛋白蛋白质酶的表达后，该反应是trake kin酶蛋白的表达 zeae-maydis , expression of a protein that recognizes effector protein secreted by Colletotrichum graminicola and signals a hypersensitive response that destroys infected tissue through programmed cell death, and expression of a protein that recognizes effector protein secreted by Puccinia polysora and signals a hypersensitive response that destroys infected tissue through programmed cell death Dear Mr. Garcia: Thank you for your letter dated 2024年8月16日，要求对使用基因工程（改良玉米）开发的玉米进行监管状态审查（RSR）。In your letter, you described that the corn was modified to impart resistance to northern corn leaf blight, resistance to gray leaf spot, resistance to anthracnose stalk rot, and resistance to southern corn rust via expression of a resistance (R) protein that recognizes effector protein secreted by Setosphaeria turcica and signals a hypersensitive response that destroys infected tissue through programmed cell death, expression of a wall-associated kinase protein that triggers downstream immune responses after detecting Setosphaeria turcica , expression of an atypical pattern recognition receptor (PRR) protein, with only a leucine rich repeat region that triggers downstream immune responses after detecting Cercospora zeae-maydis , expression of an L-type lectin receptor kinase protein that triggers downstream immune responses after detecting Cercospora zeae- maydis , expression of a protein that recognizes effector protein secreted by Colletotrichum graminicola and signals a hypersensitive response that destroys infected tissue through programmed cell death, and expression of a protein that recognizes effector protein secreted by Puccinia polysora and signals a hypersensitive response that destroys infected tissue through programmed cell death.
![arXiv:2304.02786v1 [cs.LG] 2023 年 4 月 5 日](/simg/6\6572104c226cb2e6beb8c0175c9011d97b43372c.webp)
arXiv:2304.02786v1 [cs.LG] 2023 年 4 月 5 日
后门攻击是对深度神经网络 (DNN) 模型的严重威胁，攻击者使用带有触发器的输入 (例如补丁) 来激活预先植入的恶意行为。触发器反演是识别后门模型和理解嵌入式对抗行为的有效方法。触发器反演的挑战在于构造触发器的方法有很多种。现有方法无法通过做出某些假设或特定于攻击的约束来推广到各种类型的触发器。根本原因是现有工作在制定反演问题时没有考虑触发器的设计空间。这项工作正式定义并分析了注入不同空间的触发器和反演问题。然后，它基于触发器的形式化和从我们的分析中识别出的后门模型的内部行为，提出了一个统一的框架来反演后门触发器。我们的原型 UNICORN 具有通用性，并且能够有效地反转 DNN 中的后门触发器。代码可在 https://github.com/RU-System-Software-and-Security/UNICORN 找到。
1994 年环境保护法规定的资源项目环境影响报告标准
以下触发因素被视为环境影响报告标准（第 3 节）的一部分，部门将使用它们来决定是否需要环境影响报告。如果满足其中一个触发因素，则需要制定环境影响报告。如果任何一个触发因素均不满足，并且部门在考虑了标准标准（附录 A）和第 3 节中列出的其他事项/标准后决定需要制定环境影响报告，则这并不意味着无需制定环境影响报告。例如，如果部门认为项目可能对环境产生重大影响，或者对可能的影响存在高度不确定性，或者公众对提案有很高的兴趣，则可能需要制定环境影响报告。
重症监护医学学会关于重症儿童和成人血糖控制的指南2024
METHODS: We conducted a systematic review for each Population, Intervention, Comparator, and Outcomes question related to glycemic management in criti- cally ill children ( ≥ 42 wk old adjusted gestational age to 18 yr old) and adults, including triggers for initiation of insulin therapy, route of administration, monitor- ing frequency, role of an explicit decision support tool for protocol maintenance, and methodology for glucose testing.我们确定了最好的证据，从统计上总结了证据，然后使用等级方法评估了证据质量。我们使用证据到决策框架来提出强烈或弱或作为好的实践陈述。此外，当可用的证据不足以支持建议时，还包括“在我们的实践中”声明，但是小组认为描述其实践模式可能是适当的。确定了其他主题以进行未来的研究。
Ori Bionature（M）SDN BHD 201401002514（1078588-D）Ori Bionature（M）SDN BHD 201401002514（1078588-D）
An ancient plant grown in the Tibetan Plateau Contains a unique combination of polyphenols, proanthocyanidins, and bioflavonoids, that provide extensive health benefits It offers a dual mechanism to help slow down the aging process by protect and repair mechanism The proanthocyanidins from sea buckthorn protect cells from oxidative damages that causes aging It triggers stem cell release and increases the number of circulating stem cells in the blood circulation These stem cells have the potential to transform into other more specialized cells, helping to repair damaged tissues and organs in our body Enhances collagen production, promotes collagen cross-linking and protects the skin from sunburn and photoaging Provides cardiovascular benefits lowers LDL, serum Triglyceride, increases HDL and promotes vascular repairing 5 times在保护眼睛免受可见光引起的视网膜变性
评估人类未成熟牙髓干细胞（Nestacell®）通过静脉内给药的生物分布：一种非临床研究
我们使用专门的DP外植物方法成功地掌握了DPSC的分离，从而通过连续的DP机械转移来促进细胞增殖，从而产生了人类未成熟的牙髓基质/干细胞（HIDPSC）[8,11]。我们的发现支持了这一独特的成年MSC子集的潜力，该子集是从六到十二岁的儿童的落叶牙中分离出来的，作为治疗神经退行性疾病的有希望的候选者[2,8,10,12-15]。This promise stems from their ectomesenchymal origin (neural crest), which inherently triggers hIDPSCs to produce and release various neural factors, including nestin (a marker of neural stem/progenitor cells) [16,17] and high level of brain- derived neurotrophic factor (BDNF, which is depleted in patients with Huntington's disease – HD) [3,11,18].尽管观察到来自各种组织和HIDPSC的MSC之间的差异，但它们明确地符合国际细胞治疗学会定义多能MSC的所有标准[19,20]。
