土著藏族已经开发了自适应生理机制,以应对Qinghai-Xizang高原的低氧环境。据报道,与缺氧诱导因子途径相关的内皮PAS蛋白1基因(EPAS1)内的遗传变异与藏族之间的低氧适应性有关。大脑在体内表现出最高的氧气消耗,特别容易受到高空缺氧的影响。我们研究了Qinghai-Xizang高原中藏族的结构和功能性脑网络的遗传影响。在这项研究中,招募了135名年轻土著藏族(62名男性和73名女性)作为实验组。 65名与相关特征相匹配的低地汉族人被招募为遗传变异分析的对照组。基于先前的报道,选择了EPAS1中的12个单核苷酸多态性基因座进行基因分型。随后,使用磁共振成像(MRI)获得了大脑的T1结构和静止状态功能图像。单倍型分析表明,藏族中GA和CAAA单倍型的频率明显高于低地汉族个体。藏人被认为是更高的适应性。因此,藏族被归类为遗传适应的藏族(GHA-tibetans)和遗传适应性较低的藏人(GLA-tibetans)。自适应的大脑变化也参与了自发的休息状态活动网络。与Gla-tibetans相比,Gha-tibetans在左中央回和右侧毛氨酸回去,右侧额叶和右后扣带回回去的皮质表面积明显更大,在左PericalCarine Gyrus和右PericalCarine Gyrus和右上角的皮质体积中,右侧额叶和右后扣回去。在多个网络中观察到功能连接显着提高,包括体育体网络,腹侧注意网络,视觉网络和默认模式网络。这项研究揭示了EPAS1遗传变异与土著藏族中大脑结构和功能网络的适应性之间的关系,表明大脑的适应性变化主要集中在与视觉感知,运动控制和相关功能网络相关的区域上。这些大脑变化可能有助于土著人口在极端环境中更好地调节其身体活动。
1. 以正楷填写全名及地址。应列明所有联名登记持有人的姓名。2. 请填写本代表委任表格所登记的本公司股份数目。如未填写任何数目,本代表委任表格将被视为与所有登记于您名下的股份有关。3. 如希望委任会议主席以外的任何代理人,请删除“会议主席”或并在所提供的空白处填写所需代理人的姓名及地址。对本代表委任表格的任何更改均须由签署人亲自签章。如未填写姓名,会议主席将担任代理人。4. 本决议仅作摘要说明。全文载于本公司会议通知。 5. 重要提示:如果您希望投票赞成某项决议,请在“赞成”方框中打勾。如果您希望投票反对某项决议,请在“反对”方框中打勾。如果未给出指示,您的代理人可以按照其认为合适的方式投票或弃权。您的代理人还有权自行决定对除召集会议通知中提及的决议之外的任何正式提交会议的决议进行投票。6. 本代理表格必须由您或经书面授权的您的律师签署,如果是公司,则必须在其公章下或由经正式授权签署该表格的官员、律师或其他人员签署。7. 有权出席会议并投票的任何公司股东均有权委任另一人作为其代理人,代替其出席会议并投票。持有两股或以上股份的股东可委任多于一名代表出席大会并代表其投票,但如委任多于一名代表,委任书须列明每名代表所代表的股份数目。代表无须为本公司股东,但必须亲自出席大会以代表阁下。8. 本委任表格连同签署本委任表格的授权书或其他授权文件(如有)或该等授权书或授权文件的经核证副本,须于大会或其任何续会指定举行时间前至少 48 小时送达本公司香港股份过户登记分处联合证券登记有限公司,地址为香港北角英皇道 338 号华懋交易广场二期 33 楼 3301-04 室,方为有效。 9. 就股份联名持有人而言,任何一名联名持有人均可亲自或委派代表就该股份投票,犹如他/她独自拥有该股份的投票权,但如果有多于一名联名持有人出席会议,则应接受优先投票人(无论是亲自或委派代表)的投票,而排除其他联名持有人的投票。就此而言,优先次序应按联名持股的公司股东名册上的姓名顺序确定。10. 填妥及交付本代表委任表格并不妨碍任何股东出席股东大会并亲自投票(如该股东愿意),在此情况下,本代表委任表格应被视为撤销。
致谢 ............................................................................................................................. 67
号质量,提高信噪比。特征提取根据特定的BCI范式所设计的心理活动任务相关的神经信号规律,采用时域、频域、空域方法或相 结合的方法提取特征。模式识别通过采用先进的模式识别技术或机器学习算法训练分类模型,针对特定的用户定制特征提取和解 码模型。 3. 控制接口:根据具体的通信或控制应用要求,控制接口把上述解码的用户意图所表征的逻辑控制信号转换为语义控制信号,并由
5 上海交通大学生物医学工程学院,上海,200030 【摘要】脑机接口(BCI)设备是进行神经刺激和记录的重要工具,在神经系统疾病的诊断和治疗中有着广阔的应用前景。此外,磁共振成像(MRI)是一种有效且非侵入性的全脑信号捕获技术,可以提供大脑结构和激活模式的详细信息。将BCI设备的神经刺激/记录功能与MRI的非侵入性检测功能相结合对脑功能分析具有重要意义。然而,这种结合对神经接口设备的磁和电性能提出了特定的要求。首先探讨了BCI设备与MRI之间的相互作用,随后对二者结合可能产生的安全风险进行总结和整理,从BCI设备的金属电极、导线等危害的来源入手,分析了存在的问题,并总结了目前的研究对策。最后,简要讨论了BCI磁共振安全性的监管问题,并提出了增强相关BCI设备磁共振兼容性的建议。
ISSN 1004‑9037,代码元SCYCE4数据采集与处理杂志卷。37,编号6,2022年11月,第pp。1401-1411 doi:10。16337/j。1004-9037。2022。06。020ⓒ2022撰写的数据采集与处理杂志
A.General .............................................................................................................................................. 5 1.Scope of Bid ..................................................................................................................................................................... 5 2.Source of Funds .............................................................................................................................................................. 5 3.Fraud and Corruption .................................................................................................................................................... 5 4.Eligible Bidders ................................................................................................................................................................ 6 5.Eligible Goods and Related Services ........................................................................................................................... 7 B.Contents of Bidding Document ........................................................................................................ 7 6.Sections of Bidding Document ................................................................................................................................... 7 7.Clarification of Bidding Documents ............................................................................................................................ 8 8.Documents Establishing the Eligibility of the Bidder ............................................................................................ 11 17.Amendment of Bidding Documents ........................................................................................................................... 8 C. Preparation of Bids ............................................................................................................................ 8 9.Cost of Bidding................................................................................................................................................................ 8 10.Language of Bid ............................................................................................................................................................... 8 11.Documents Comprising the Bid ................................................................................................................................... 8 12.Bid Submission Sheet and Price Schedules ................................................................................................................ 9 13.Alternative Bids ............................................................................................................................................................. 10 14.Bid Prices and Discounts ............................................................................................................................................. 10 15.Currencies of Bid .......................................................................................................................................................... 11 16.Documents Establishing the Eligibility of Goods and Related Services............................................................. 11 18.12 19。文件,确定商品及相关服务的合规性。Documents Establishing the Qualifications of the Bidder .................................................................................... 12 20.Period of Validity of Bids ............................................................................................................................................ 12 21.Bid Security .................................................................................................................................................................... 12 22.Format and Signing of Bid .......................................................................................................................................... 13 D. Submission and Opening of Bids .................................................................................................... 13 23.Sealing and Marking of Bids ........................................................................................................................................ 14 24.Deadline for Submission of Bids ................................................................................................................................ 14 25.Late Bids ......................................................................................................................................................................... 14 26.撤回,替代和修改出价...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................Bid Opening ................................................................................................................................................................... 15 E. Evaluation and Comparison of Bids ............................................................................................... 15 28.Confidentiality ................................................................................................................................................................ 15 29.Clarification of Bids ...................................................................................................................................................... 16 30.Responsiveness of Bids ................................................................................................................................................ 16 31.不合格,错误和遗漏............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 16 32。Preliminary Examination of Bids ............................................................................................................................... 17 33.审查条款和条件;技术评估...............................................................................Conversion to Single Currency ................................................................................................................................... 17 35.Margin of Preference .................................................................................................................................................... 17 36.Evaluation of Bids ......................................................................................................................................................... 18 37.Comparison of Bids ...................................................................................................................................................... 19 38.Post-qualification of the Bidder .................................................................................................................................. 19 39.Procuring and Disposal Entity's Right to Accept Any Bid, and to Reject Any or All Bids ............................ 19 F. Award of Contract............................................................................................................................ 19 40.Award Criteria ................................................................................................................................................................ 19 41.Procuring and Disposal Entity's Right to Vary Quantities at Time of Award ................................................... 19 42.Notification of Award .................................................................................................................................................. 19 43.Signing of Contract ....................................................................................................................................................... 20 44.Performance Security.................................................................................................................................................... 20