糖尿病性心肌病(DCM)是糖尿病的常见并发症之一,作为特定的心肌病,在心脏的结构和功能上具有异常。随着糖尿病患病率的增加,DCM在全球范围内具有高发病率和死亡率。最近的研究发现,作为一种程序性细胞死亡,伴有炎症反应,加剧了DCM的生长和起源。这些研究为探索DCM的潜在处理提供了理论基础。Therefore, this review aims to summarise the possible mechanisms by which pyroptosis promotes the development of DCM as well as the relevant studies targeting pyroptosis for the possible treatment of DCM, focusing on the molecular mechanisms of NLRP3 in fl ammasome-mediated pyroptosis, different cellular pyroptosis pathways associated with DCM, the effects of pyroptosis occurring in different cells on DCM和针对NLRP3炎症/热胞菌的相关药物用于治疗DCM。本评论可能为开发DCM的治疗剂提供了新的视角和基础。
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