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流行的勃起功能障碍药物与威胁视力的眼病有关
长期服用他达拉非（西力士）的人可能需要定期进行眼睛健康监测。他达拉非（西力士）是一种广泛用于治疗勃起功能障碍的药物，也用于治疗与前列腺肥大相关的尿急和尿频。 《英国眼科杂志》在线发表的一项大型比较研究发现，接受该药物的男性 [...]
来源:SciTech日报长期服用他达拉非（西力士）的人可能需要定期进行眼睛健康监测。
Tadalafil (Cialis), a medication widely known for treating erectile dysfunction, is also prescribed for urinary urgency and frequency associated with an enlarged prostate. A large comparative study published online in the British Journal of Ophthalmology has found that men receiving the drug for these symptoms had a higher likelihood of developing glaucoma, a serious eye condition that can damage vision.
The researchers say the findings support careful eye monitoring for patients who take tadalafil long term for this purpose, particularly those who already have glaucoma risk factors, including a family history of the disease or elevated pressure inside the eye (ocular hypertension).
他达拉非属于一组称为 5 型磷酸二酯酶抑制剂 (PDE5i) 的药物，其中还包括西地那非（伟哥）。 Previous research has associated these drugs with several eye conditions involving structures such as the optic nerve and the macula, the part of the retina responsible for sharp, detailed vision.
然而，具体将 PDE5i 药物与青光眼联系起来的证据仍然不一致且不确定。 The uncertainty is especially relevant for tadalafil when it is prescribed for lower urinary tract symptoms because treatment commonly involves taking the medication every day over long periods.
长期使用会引发安全问题
To investigate that possible connection, researchers examined whether tadalafil, a long-acting PDE5i, was associated with an increased risk of glaucoma when used to manage urinary symptoms caused by an enlarged prostate (benign prostatic hyperplasia).
The researchers compared the two groups over five years, examining the likelihood of developing glaucoma, ocular hypertension, or beginning treatment for glaucoma.
他达拉非使用者表现出更高的眼部风险
研究无法确定因果关系
DOI：10.1136/bjo-2026-329957