LaIT6: A Novel Insect-Selective K+-Channel Toxin from Liocheles australasiae Scorpion Venom
lait6：一种新型的昆虫选择的K+ - 通道毒素，来自澳大利亚大蝎子的葡萄球菌Scorptractscorpion毒液中含有各种杀虫肽。以前，通过对澳大利亚的毒液腺体的转录组分析，我们确定了几种肽的前体序列，它们共享类似于在K+通道上作用的序列的序列。在这项研究中，我们化学合成了毒液中发现的五种肽，并评估了它们针对板球的杀虫活性。这表明其中一种名为LAIT6的肽表现出显着的杀虫活性而没有哺乳动物的毒性。为了鉴定对Lait6杀虫活性重要的氨基酸残基，主要通过将酸性，碱性和芳族残基与丙氨酸取代，从而合成了九种类似物。这表明C末端区域的两个基本残基和一个芳族残基对活动很重要。在作用于K+通道的肽中
Housing August 11th Weekly Update: Inventory down 0.8% Week-over-week; Down 10% from 2019 Levels
ALTOS报告说，积极的单户库存下周下降了0.8％。候选人现在比一月份的季节性底层增长了37.6％。通常，库存比本周本周的季节性低约21％。 So, 2025 was a larger than normal increase in inventory.The first graph shows the seasonal pattern for active single-family inventory since 2015. Click on graph for larger image.The red line is for 2025. The black line is for 201
S&P 500 Healthcare Weighting At Multi-Decade Lows
S＆P 500医疗保健加权在多十年的低谷收入季节已经结束了大型生物制药的股票，随着医疗保健行业在标准普尔500中的权重跌至多年级低点，许多名称的巨大抛售。在特朗普政府最受欢迎的国家（MFN）医疗补助的定价建议和药品关税的前景中，这一领域的悲观主义提升。 Here are some of the highlights of the note titled "Global Healthcare: Pharmaceuticals: Friday Fodder: Slimmer Positioning Into The August Lull": Earnings season ended with
American AI Companies Open Up To Counter China
American AI Companies Open Up To Counter ChinaAuthored by Catherine Yang via The Epoch Times (emphasis ours),OpenAI on Aug. 5 released two open-weight language models, the company’s first such release since GPT-2 in 2019.This illustration photograph shows screens displaying the logo of DeepSeek, a C
News Wrap: Army sergeant accused of shooting 5 soldiers at Fort Stewart
In our news wrap Wednesday, an Army sergeant is accused of shooting five soldiers at Fort Stewart in Georgia, U.S. envoy Steve Witkoff met with Russian President Putin for what a Kremlin aide called 'useful and constructive' talks, Gaza health officials say at least 38 people were killed while tryin
Shale Giant Diamondback Slashes CapEx Again Ahead Of Crude Supply Flood
页岩巨头响尾蛇在几个月前的原油供应洪水之前再次削减了资本支出，当时的响尾蛇特拉维斯·斯蒂斯（Travis Stice）的首席执行官宣布美国页岩油的产量达到了顶峰，这一预测使整个行业震惊。 It was also accurate (for now): since then, domestic crude drilling activity has dropped by 12% to the lowest in almost four years.The CEO also took the rational and prudent step of slashing the Permian sha
Ugly, Tailing 3Y Auction Sees Worst Foreign Demand Since 2023
Ugly, Tailing 3Y Auction Sees Worst Foreign Demand Since 2023One week after the Treasury's refunding announcement unveiled no major changes to the coupon auction schedule for the next few months, instead punting everything to Bills and leading to the following headline this morning:*US TREASURY TO A
Ukraine Claims Drone Strike On 5 Russian Fighter Jets At Crimean Base
乌克兰声称，在克里米亚基地的安全部门（SBU）对5架俄罗斯战斗机的无人机罢工宣布，在一夜之间，在克里米亚的一座城市萨基（Saky）的俄罗斯空军中，成功进行了无人机袭击。这是在周末袭击俄罗斯内部的袭击之后，袭击了石油炼油厂和一家与军事联系的电子工厂。SBU声称在该基地的五架俄罗斯军用飞机上直接击中，据报道，该飞机摧毁了一架Su-30SM战斗机，并损坏了另一架。乌克兰还表示，其无人机击中了另外三架SU-24轰炸机，以及对存储航空弹药的仓库的袭击。SU-30SM飞机，通过RBC乌克兰Saky Airfield长期以来一直是黑海地区俄罗斯军事活动的关键枢纽。 SBU称这次罢工为“重要” - 鉴于单个
Repeat home sales and leading apartment rent indexes both point to lower shelter inflation ahead
- 通过新的民主党，FHFA和S＆P Case Shiller的早晨的重复家庭销售报告对卖家来说不是好消息 - 但对于未来的消费者通货膨胀读数而言，非常好消息，在季节性调整的基础上，在5月的三个月平均至5月的平均值，Case -Shiller National Index（下图下图中的淡蓝色）拒绝了-0.3％，而FHFHFA则拒绝了-2％。就FHFA指数而言，这是连续第二个下降。在CASE-SHILLER索引中，第三个。 This is on par with the declines we last saw in the summer of 2023 (note: as per usual,
EU Slashes $1.7BN In Aid To Ukraine Over Corruption Concerns: 'Exasperation From Biggest Donors'
欧盟削减了17亿美元的援助乌克兰的腐败问题：“最大的捐助者的愤怒我们已经到达Zelensky的尽头？这个咒语是普京和俄罗斯的比赛和胜利吗？以下是《纽约时报》（New York Times）的硬新闻页面非常罕见的：美国反腐败专家詹姆斯·瓦斯斯特罗姆（James Wasserstrom）在接受采访时说：“光泽肯定会脱颖而出” Zelensky先生在提供财政援助的政府中的战时领导才能。 He added, “There is exasperation at Zelensky in the donor community.”Early last week, there were unexpected
Some interesting links that I Tweeted about in the last week (I also post these on Mastodon, Threads, Newsmast, and Bluesky):The "fair use" defence of AI companies scraping the web for training data is not valid in the EU: https://www.theregister.com/2025/07/14/eu_genai_fair_use/For safety, we need
US New Home Sales Disappoint In June As Prices Plunge
US New Home Sales Disappoint In June As Prices PlungeFollowing yesterday's disappointing existing home sales print, this morning sees new home sales confirm the disappointment with a mere 0.6% MoM rise (well below the 4.3% MoM rebound expected after tumbling 11.6% MoM the month prior)...Source: Bloo
PMI Surveys Show Manufacturing Slump, Services Jump In July
PMI Surveys Show Manufacturing Slump, Services Jump In JulyAfter rallying to multi-year highs in June, the preliminary July print for S&P Global's US Manufacturing PMI tumbled to 49.5 - its lowest level of the year.At the same time, US Services soared to 55.2 - its highest since Dec 2024Source: Bloo
It's The Meme Craze Of 2021 All Over Again: Here Are The Most-Shorted Stocks That Could Soar
这是2021年的模因热潮再次：这是所有这些股票最多的股票，可以为所有这些地下室零售商交易者飙升，他们的生活中的一个梦想是重现臭名昭著的gameStop名人的咆哮小猫，并短暂地挤压了他们的名声和有钱人（在昨天造成了一些很棒的东西）（我们的范围很棒） unprecedented, historic gamma squeeze in Opendoor Technologies (OPEN) stock (and Chamath SPAC), which saw a record surge in call option activity...... concurrently with an expl
Nike Averts 'Bud Light' Moment With Pro-Family Ad Pivot Amid Overton Window Shift
Nike避免了“芽灯”的时刻，在Overton Window的窗口中，在overton Window中移动了overton窗口，即在美国，社会上可接受的东西已急剧转移到中央右翼 - 十年后人工固定在遥远的左边。诸如儿童的拖拉皇后故事小时，身体积极性和其他唤醒的玛克斯主义趋势之类的进步事业，这些趋势可以说是退化的社会，并且在足够长的时间表上被视为杀死民族，现在被拒绝了。在一定程度上要感谢埃隆·马斯克（Elon Musk）的X和特朗普总统的玛格（Maga）运动，迪伊（Dei）和唤醒议程的崩溃为亲家族价值观，民族骄傲，国家安全增加和美洲的复兴铺平了道路。周一，互联网嗡嗡作响的是，在周日在皇家肖像的2
Tuesday: Fed Chair Powell, Richmond Fed Mfg
从马修·格雷厄姆（Matthew Graham）到抵押新闻：抵押贷款利率的移动略低，以开始新的周期贷款利率并没有在周一移动太多，但是他们朝着正确的方向移动，平均贷方平均贷方为上周五的30yr固定情况下降了0.03％。 That makes this the 4th straight business day with a modest gain and it gets us back in line with the lowest rates since July 3rd. [30 year fixed 6.78%]emphasis addedTuesday:• At 8:30 AM ET,
US Orders New Restrictions On Flights From Mexico Amid Aviation Dispute
美国在瑞安·摩根（Ryan Morgan）通过《时报》（Epoch Times）纠纷的航空中命令对从墨西哥飞行的新限制，美国运输部在7月19日对从墨西哥到美国的飞行运营施加了新的限制 operate large passenger or cargo charter flights between Mexico and the United States.In a July 19 statement, the U.S. Transportation Department said Mexico, since 2022, has not been in compliance with the Ai
LA Ports: Traffic Down 3% YoY in June
Container traffic gives us an idea about the volume of goods being exported and imported - and usually some hints about the trade report since LA area ports handle about 40% of the nation's container port traffic.The following graphs are for inbound and outbound traffic at the ports of Los Angeles a
