抑郁症是寻求帮助的主要情绪状况。沮丧的人经常报告持续的反省,这涉及分析和生活中复杂的社会问题。分析通常是解决复杂问题的有用方法,但是它需要缓慢,持续的处理,因此破坏会干扰解决问题。The analytical rumination hypothesis proposes that depression is an evolved response to complex problems, whose function is to minimize disruption and sustain analysis of those problems by (a) giving the triggering problem prioritized access to processing resources, (b) reducing the desire to engage in distracting activities (anhedonia), and (c) producing psychomotor changes that reduce exposure to distracting stimuli.由于处理资源是有限的,对触发问题的持续分析会降低专注于其他事物的能力。该假设得到了许多层次的证据,例如基因,神经递质及其受体,神经生理学,神经解剖学,神经术,药理学,药理学,认知,行为和治疗功效。此外,该假设为抑郁症文献中令人困惑的发现提供了解释,这挑战了抑郁症中5-羟色胺传播较低的信念,并且对治疗有影响。