12月20日,美国生物制药公司Aadi Bioscience, Inc.(“Aadi”)(纳斯达克股票代码:AADI)宣布,已与中国药明生物和杭州DAC生物技术有限公司达成一项独家许可协议,授权其开发三种临床前抗体-药物偶联物(ADC)。Aadi还宣布以1亿美元的价格将FDA批准的血管周围上皮样细胞肿瘤治疗药物FYARRO出售给日本专科制药公司KAKEN Pharmaceutical。截至2024年9月30日,FYARRO的营收为2500万美元。这些交易使Aadi成为一家专注于ADC的公司,预计资本将用于其2028年底前的运营,并通过临床开发推进其产品线
S.No CIN Name of Company/Entity 1 L99999GJ1987PLC009768 20 Microns Limited 2 U74140MH2008PLC177884 360 ONE WAM LIMITED 3 L24211MP1972PLC001131 3B BlackBio Dx Limited 4 L67120MH1993PLC074411 3i Infotech limited 5 L31300KA1987PLC013543 3M India Ltd. 6 L7499999999999999PLC013394 3P Land Holdings Ltd。 7 L74900MH2012PLC230802 3RD ROCK MULTIMEDIA LIMITED 8 L67190MH2007PLC289249 5PAISA CAPEDAL LIMITED 9 L29142TN1988PLC015555586 63 MOONS TECHNOGIES 63 MOONS TECHALLICES TECHNOGIES TECHNOGIES TECHNOGIES TECHNOGIES TECHNAGIES TECHNAGIES TECHNAGIES MOLIVITE L72900TG1991PLC013074 7SEAS Entertainment Limited 12 L25202GJ2011PLC065632 A和M Jumbo Bags Limited 13 U17111PB1997PLC02LC020118 A B COTSPIN I INDIOND INDIA L55101DL2005PLC140406 A B n Intercorp Limited 16 U25200DL2008PLC178400 A G通用有限公司17 L85110DL1984PLC018486 A.D.S.Diagnostics Ltd. 18 L18100DL1983PLC016354 A.F.Enterprises Limited 19 L17117RJ1994PLC008916 A.K.spintex Ltd. 20 L74899MH1993PLC274881 A.K.Capital Services Ltd. 21 L24119GJ2004PLC044011 A-1酸LIMITED 22 L749999999999HR2002002002PLC034805 A2Z INFRA ENGINETEN 24 L72100MH2000PLC128949 AAA Technologies Limited 25 L67120GJ1995PLC0244449 Aadhaar Ventures India India Limited 26 L25203MH1994PLC2LC206053 AADI Industries Aadi Industries Ltd 27 L65990MH1999991PLC066666631 AAGAMCODAIL 27 U23209GJ2007PLC049792 Aakash Exploration Services Limited 29 L17121TG2013PLC086564 AANANDA LAKSHMI旋转磨机30 L27106WB1996WB1996PLC076866 ANANCHAL ISPAT ISPAT ISPAT ISPAT ISPAT LIMICE ISPAT MAINDE ISPAT 31 L67120DL1983 PLL1983 PLC066666666666652平面L99999MH1990PLC056538 AAREY药物和药品33 L17100GJ1983PLC0289990 AARNAV FASHIONS LIMITED 34 U31908GJ20132013PLC07777777306 AARON INDUSTIRE L37060MH1984PLC055433 AARTI药物有限公司37 L24110GJ1984PLC007301 AARTI Industries LTD 38 L24100GJ2019PLC110964 AARTI PHARMALABS LIMITED L17110GJ1988PLC010504 Aarvee Denims & Exports Ltd. 41 U29290MH1987PLC045499 Aarvi Encon Limited 42 L85110GJ2012PLC072647 Aashka Hospitals Limited 43 L65923DL1972PLC317436 Aashrit Capital Limited 44 L65191TN1985PLC01151503 Aastamangalam Finance Limited 45 U85100GJ2014PLC079062 AATMAJ Healthcare Limited 46 L65922RJ2011PPLC034297 AAVAS FINASIOR L01119TN1986PLC013473 Aban Offshore Ltd.
参考:1。Majithiya等。癌症Res 2023; 83(7_suppl):摘要312。Presenting author disclosures: Participated in advisory boards for: Aadi, AstraZeneca, Aravive, Alkemeres, Blueprint Pharma, Caris, Clovis, Duality, Eisai, Eli Lilly, EMD Serono, GlaxoSmithKline/Tesaro, Genetech/Roche, Hengrui, Immunogen, IMab, Merck, Mereo, Myriad, Mersana,Novartis,Novocure,Oncxerna,Onconova,Pannavance,Tarveda,VBL Therapeutics,Verastem,Zentalis; GOG Partners的副主任;主席:NRG卵巢癌;董事会成员:ASCO,GOG基金会;来自:最新的特许权使用费; Prinicpal研究人员:Artios,Astra Zeneca,Bolt,Daiichi Sankyo,Duality,Eli Lilly,Glaxosmithkline/ Tesaro,Tesaro,Immunogen,PTC Therapeutics,Regeneron,Regeneron,Verastem,Verastem。致谢:我们要感谢参加了这项研究的患者,他们的家人,研究地点和研究人员。我们还要感谢Costello Medical Creative Team的设计支持,以及Costello Medical BSC的Erin Clarkson提供编辑援助;对执行CTDNA分析的护卫健康和用于执行CTC分析的医学精确度。这项研究由Artios资助。与此海报的开发相关的所有费用均由Artios资助。ART0380是通过MDACC和Shangpharma之间的合作来确定的。该化合物在2019年被Artios固定。
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S.No CIN Name of Company/Entity 1 L99999GJ1987PLC009768 20 Microns Limited 2 U65990MH1994PLC080646 360 ONE Prime Limited 3 L74140MH2008PLC177884 360 ONE WAM Limited 4 L67120MH1993PLC074411 3i Infotech limited 5 L31300KA1987PLC013543 3M印度有限公司。 6 L74999MH1999PLC013394 3P Land Holdings Ltd。 7 L74900MH2012PLC230802 3RD ROCK MULTIMEDIA LIMITED 8 L67190MH2007PLC289249 5PAISA CAPEDAL LIMITED 9 L29142TN1988PLC015555586 63 MOONS TECHNOGIES 63 MOONS TECHALLICES TECHNOGIES TECHNOGIES TECHNOGIES TECHNOGIES TECHNAGIES TECHNAGIES TECHNAGIES MOLIVITE L72900TG1991PLC013074 7SEAS Entertainment Limited 12 L28113GJ2013PLC075662 A&M FebCon Limited 13 L25202GJ2011PPLC065632 A和M JUMBO BAGS LIMITED L45202MH2011PLC214834 A B INFRABUILD LIMITED 16 L55101DL2005PLC140406 A B N INTERCORP LIMITED 17 L85110DL1984PLC018486 A.D.S.Diagnostics Ltd. 18 L18100DL1983PLC016354 A.F.Enterprises Limited 19 U51900MH2006PLC214277 A.K.Capital Finance Ltd. 20 L17117RJ1994PLC008916 A.K.Spintex Ltd. 21 L74899MH1993PLC274881 A.K.Capital Services Ltd。 22 L24119GJ2004PLC044011 A-1 ACIC LIMITED 23 L7499999HR2002PLC034805 A2Z INFRA ENGINEERING LIMITED 24 U74900MH2016PLC274726 AA AA PLUS TRACHELINK PLUS TRADELINK有限公司L67120GJ1995PLC024449 Aadhaar Ventures India Limited 27 U65922KA2010PLC096680 AADAHAR HOUSING FINANACE LIMITED 28 AADHAR HOADHAR HOADHAR HOUD FINANCE LTD 29 L25203MH19994PLC20606053 AADIDI INDUSTRION Aagam Capital Limited 31 L23209GJ2007PLC049792 Aakash Exploration Services Limited 32 L17121TG2013PLC086564 AANANDA LAKSHMI SPINNNING MILLS LIMITED 33 L27106WB1996WB1996PLC076866 AACHALL COLLACTIT Limited 35 L67120DL1983PLC015266 AAR SHYAM印度投资公司有限公司36 L999999990PLC056538 AAREY DRUGS& Pharmaceuticals Ltd 37 L17100GJ1983PLC028990 AARNAV FASHIONS LIMITED 38 L31908GJ2013PLC077306 Aaron Industries Limited 39 L31200MP1982PLC002030 Aartech Solonics Limited 40 L37060MH1984PLC055433 Aarti Drugs Limited 41 L24110GJ1984PLC007301 AARTI Industries Ltd 42 L24100GJ2018PLC102891 AARTI表面活性剂有限公司43 L17110GJ1988PLC0101044 AARVEE DENIMS&amp&amp& Exports Ltd. 44 L29290MH1987PLC045499 AARVI ENCON LIMITED 45 U85110GJ2012PLC072647 AASHKA HOSSHITALS LIMITED
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参考文献 1. Zhou S 等人。Front Immunol。2023;14:1129465。2. Schoenfeld AJ 等人。Cancer Discov。2024;14:1389–402。3. Garon B 等人。N Engl J Med。2015;37:2018–28。缩写 AE,不良事件;BOR,最佳总体缓解;CI,置信区间;CR,完全缓解;CY,环磷酰胺;DCR,疾病控制率;DOR,缓解持续时间;ECOG,东部肿瘤协作组;EGFR,内皮生长因子受体;EOA,评估结束;EOS,研究结束;EOT,治疗结束;FLU,氟达拉滨;GMP,良好生产规范;ICI,免疫检查点抑制剂;IL-2,白细胞介素-2;NE,不可评估; NR,未达到;NSCLC,非小细胞肺癌;ORR,客观缓解率;PD,进展性疾病;PD-L1,程序性细胞死亡-1配体;PR,部分缓解;PS,体能状态;Q3W,每 3 周一次;Q6W,每 6 周一次;RECIST,实体肿瘤疗效评价标准;SD,疾病稳定;SOD,直径总和;TEAE,治疗中出现的不良事件;TIL,肿瘤浸润淋巴细胞;TKI,酪氨酸激酶抑制剂;TPS,肿瘤比例评分;wt,野生型。披露 Benjamin C Creelan:Achilles Therapeutics plc、Aptitude Health、AstraZeneca、Boehringer-Ingelheim、DAVA Oncology、ER Squibb & Sons, LLC、G1 Therapeutics, Inc、Hoffman LaRoche、Iovance Biotherapeutics、Jannsen、Johnson&Johnson、MJH Healthcare Holdings, LLC、OmniHealth Media、Regeneron、VJ HemeOnc;Kai He:AbbVie、Adaptimmune、Amgen、AstraZeneca、BioNTech SE、Bristol Myers Squibb、Genentech/Roche、GSK、Iovance Biotherapeutics、Lyell Immunopharma、Mirati Therapeutics、Obsidian Therapeutics、OncoC4、Perthera; Edward Garon:A2 Bio、AbbVie、ABL-Bio、Arcus、Arrivent、AstraZeneca、Atreca、Black Diamond Therapeutics、BridgeBio、Bristol Myers Squibb、Daiichi-Sankyo、Eli Lilly、EMD Serono、Genentech、Gilead、Hookipa、I-Mab、Iovance Biotherapeutics、iTeos、LianBio、Merck、Merus、Mirati、Novartis、Nuvalent、Pfizer、Prelude、Regeneron、Sanofi、Seagan、Sensei、Sumitomo、Strata、Summit、Synthekine、TILT Biotherapeutics;Jason Chesney:无可披露;Sylvia Lee:Bristol Myers Squibb、Iovance Biotherapeutics、Kite Pharma、Lyell Immunopharma、Seagen; Jorge Nieva:Aadi Biosciences、Affyimmune、ANP Technologies、AstraZeneca、BioAtla、Cansera、Epic Sciences、G1 Therapeutics、Genentech、Indee Bio、Kalivir、Merck、MindMed、Naveris、Sanofi;Adrian Sacher:AdaptImmune、Amgen、AstraZeneca、BridgeBio、Bristol Myers Squibb、CRISPR Therapeutics、Genentech、Genentech-Roche、GSK、HotSpot Therapeutics、Iovance Biotherapeutics、Lilly、Merck、Pfizer、Spectrum;Friedrich Graf Finckenstein:专利、版权费、其他知识产权:Bristol Myers Squibb;就业情况:Iovance Biotherapeutics。股票或股票期权:Iovance Biotherapeutics; Brian Gastman、Jeffrey Chou、Rana Fiaz、Melissa Catlett、Guan Chen:Iovance Biotherapeutics;Adam Schoenfeld:Achilles Therapeutics、Affini-T Therapeutics、安进、阿斯利康、百时美施贵宝、cTRL therapy、Enara Bio、GSK、Harpoon Therapeutics、Heat Biologics、Immunocore、Iovance Biotherapeutics、Johnson&Johnson、KSQ Therapeutics、Legend Biotech、Legend Therapeutics、Lyell Immunopharma、Merck、Obsidian Therapeutics、Oppenheimer and Co、PACT Pharma、Perceptive Advisors、Prelude Therapeutics、Regeneron、Synthekine、Umoja Biopharma。致谢 • 本研究由 Iovance Biotherapeutics, Inc.(美国加利福尼亚州圣卡洛斯)赞助 • 医学写作和编辑支持由 OPEN Health 公司 Peloton Advantage, LLC 提供,并由 Iovance 资助 • 特别感谢 IOV-COM-202 研究患者及其家属