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专科医疗福利药品清单
Antineoplastic Agents Abraxane, Adcetris, Adstiladrin, Alimta, Aliqopa, Alymsys, Anktiva, Arzerra, Asparlas, Avastin, Avzivi, Azedra, Beleodaq, Belrapzo, Bendeca, Besponsa, Blenrep, Blincyto, Columvi, Cyramza, Danxel, Darzale, Elzale, Elzala, Eprozahere rexfio, Elzonris, Empliciti, Enhertu, Epkinly, Erbitux, Erwinaze, Faslodex, Firmagon, Folotyn, Gazyva, Halaven, Hepzato Kit, Herceptin, Herceptin Hylecta, Hercessi, Herzuma, Imdelltra, Imjudo, Imlygic, Intron-A, Istomy, Jela, Jel, Katjin, Khapzory, Kimmtrak, Kyprolis, Lunsumio, Margenza, Monjuvi, Mvasi, Mylotarg, Ogivri, Oncaspar, Ontruzant, Opdualag, Padcev, Pemfexy, Pemrydi RTU, Perjeta, Phesgo, Pluvicto, Polivy, Portrazza, Poteligeo, Provence, Rioxila, Hyunce, Rtu Rix vant, Rylaze, Sarclisa, Synribo, Talvey, Tecvayli, Temodar, Tivdak, Trazimera, Treanda, Trodelvy, Truxima, Vegzelma, Vivimusta, Vyxeos, Xofigo, Yervoy, Zepzelca, Zevalin, Zirabev, Zynlonta
需要预先认证的服务
Alimta, Alymsys (except for ophthalmological conditions), Anktiva, Avastin (except for ophthalmological conditions) 5 , Avzivi, Azedra 2 , Blincyto, Columvi, Cyramza, Darzalex, Darzalex Faspro, datapotamab deruxtecan 6 , Elaux, Herbi, Erbithere, Erbithere, 5 in Hylecta, Hercessi, Herzuma, Imjudo, Kadcyla, Kimmtrak, Kyprolis, Margenza, Monjuvi, odronextamab 6 , Ogivri, Ontruzant, Opdualag, Padcev, patritumab deruxtecan 6 , Pemfexy, Perjeta, Phesgo, Pluvicto, Polio, Rio, Rio, Provence, 5 , Rituxan Hycela, Ruxience, Rybrevant, Rylaze, Sarclisa, Taclantis, Talvey, Tecvayli, Tivdak, trastuzumab duocarmazine 6 , Trodelvy, Vegzelma (except for ophthalmological conditions), Xofigo 2 , Yervoy, zanidat 6, Zepzelca, Zepzelca , Zynlonta • Anti-PD-1/PD-L1 human monoclonal antibodies: 4
专科医疗福利药品清单
Antineoplastic agents Abraxane, Adcetris, Adstiladrin, Alimta, Aliqopa, Alymsys, Anktiva, Arzerra, Asparlas, Avastin, Avzivi, Azedra, Beleodac, Belrapzo, Bendeca, Besponsa, Blenrep, Blincyto, Columvy, Cyram, Darzale, Darzale, Esa, Esa, Fax antibiotic, Elrexfio, Elzonris, Empliciti, Enhertu, Epkinly, Erbitux, Erwinaze, Faslodex, Firmagon, Folotyn, Gazyva, Halaven, Hepzato Kit, Herceptin, Herceptin Hylecta, Hercessi, Herzuma, Imdelltra, Imjudo, Imlygic, Instoron-A, Jelato, Jelato, Jena, Kanjinti, Khapzory, Kimmtrak, Kyprolis, Lunsumio, Margenza, Monjuvi, Mvasi, Mylotarg, Ogivri, Oncaspar, Ontruzant, Opdualag, Padcev, Pemfexy, Pemrydi RTU, Perjeta, Phesgo, Pluvicto, Polivy, Portrazza, Potelige, Provence, Hyundai, Hyundai, Rioxila , Rybrevant, Rylaze, Sarclisa, Synribo, Talvey, Tecvayli, Temodar, Tivdak, Trazimera, Treanda, Trodelvy, Truxima, Vegzelma, Vivimusta, Vyxeos, Xofigo, Yervoy, Zepzelca, Zevalin, Zirabev, Zynlonta >
MassHealth ACO/MCO专业药物清单
品牌名称genic名称adamimumab-adbm（cf）pen adamimumab-adbm adlimumab-fkjp（cf）adamimumab-fkjp adallimab-fkjp（cf）pen adbkjp adbkjp adbkjp adbryumbryumbryab-dtrmdab-dtrmdab-dtrmdab-dtrmdab-dcjp布伦毒蛋白vedotin adcirca tadalafil adempas riociguat adrimycin adribiubicin hcl adrucil fuororouracilacilacilacilacilacilacilacilacilacilacialacialacialacialacialacialacialacialacialacialacialacibamab-avwa向抗imophil.fviiiii ad Adynoviii danynovate antynovate antiynovate antihemoi.fviiii.fviii， Disperz verolymus afstyla antihem.fviii,sin-chn,b-dm tram autovig autoinjector Ereumab-aooe Ajovy Freezumab-Vrm Ajovy Autoinjector Fremanezumab-Vffrm akeegae Alduathaseasee auturarib-Vrm Alectinib HCl Alferon n Interferon alfa-n3 alimta potetrexed disodium aliqopa copanlib di-hcl Alkeran alkeran melphaan melphalan melphalan melphalan melphalan melphalan hlphaan hcl alphanate抗孕妇抗孕妇抗孕妇抗孕酸抗孕妇抗雌激素/vwfαααα-ααα- rec，fc-vwf-xten，bddddddddl unbriginbarginib alviz altrombopag胆碱
医疗益处肿瘤药物类政策
药物名称受益HCPCS Alimta（Pemetrexed）医疗J9305 Bizencutuzumab-ZBCO医疗J3590 Daanyelza（Naxitamab-GQGK） Soravtanne-Gynx）医疗J9063 Elahere Medical J9063 Elahere Medical J9063 Elahere Medical J9063 Elahere Medical J9063 Elahere Medical J9063 Elahere Medical J9063 Elahere Medical J9063 Elahere Medical Medical Medical J9063 Elezonris（Tagraxoffusp-erbit-imim j9069）ERETIM J90699269969699696969692696969696969692699696969696969696969696969969696969.26669666963号。 J9055 Fyarro（Sirumus蛋白启动颗粒）医疗J9331 J9331 J9331 J9331 J9331 J9331 J9331 J9331 J9281 Kimmtrak（Tebentafusp-tebn） vedotin-ejfv）医疗J9177 Pemetrexed Medical J9296，J9294，J9297，J9314，J9323，J9323，J9322，J9292 PEMFXY（PEMETREXED）（PEMETREXED） vedotin-piq）医疗J9309 Rybrevant（Amivaantamab-vmjw）医疗J9061 Sarclisa（isatuximab-irfc）医疗J9227 Tivdak（Tisotutututututututututututututututututututututututututututututututututututututututututututututututututututututftv） （zolbetuximab-clzb）医疗J3590 Yondelis（TrabectedIn）Medical J9352 Zihera（Zanidamab-hr）Medical J3590 Zynlonta（Loncastuxituximab tesirine-lpyl）
复杂药物产品的冻干：配方挑战和扩大规模
冻干（也称为冷冻干燥）是一种通过水或其他溶剂的升华和解吸将液体转化为固体的过程。该过程包括三个高度相互关联的阶段：冷冻、初级干燥（升华）和二次干燥（解吸）。冻干通常用于稳定在液体或冷冻形式下不稳定的活性药物成分 (API) 和配方。由于冻干不需要加热，因此它是热敏感 API 和生物制剂（如蛋白质和肽）的理想干燥方法。当使用冻干制造肠外药物产品时，所得粉末被密封在小瓶、药筒或注射器内。在给药前，将冻干粉重新配制或与液体稀释剂混合，以形成用于注射的均匀溶液或悬浮液。冻干粉的高表面积允许在床边快速重新配制（即补液）和注射，这对于紧急产品特别有用。这些产品高度稳定，保质期通常超过两年。冻干也可用于生产中间粉末，然后进一步加工成最终剂型。例如，可将具有高残留溶剂含量和热敏感性的粉末冻干，以在进行进一步加工之前除去溶剂。冻干也可用于生产稳定、可流动的粉末，以进行研磨或直接压片。在需要非常小的填充量的粉末填充中，将粉末溶解在液体中并冻干有助于控制重量，因为控制液体填充的体积更容易。冻干最重要的特性或许是它与无菌操作的兼容性，使其成为从开发开始的肠外给药的可靠选择。 2013 年至 2015 年，获批的注射和输注药物中，有一半是冻干产品，而 1990 年至 1981 年，冻干产品仅占 10%。这其中包括价值数十亿美元的小分子药物 Alimta®，以及 Lupron Depot®、Keytruda® 和 Herceptin® 等重磅生物制剂。随着复杂配方和水稳定性较差的生物制剂变得越来越普遍，冻干药物产品的增长预计只会持续下去。