摘要:本研究论文探讨了将人工智能 (AI) 和机器学习 (ML) 集成到业务规则管理系统 (BRMS) 中以开启决策支持新时代的变革潜力。该研究重点关注下一代决策框架,深入研究了 AI 和 ML 技术的协同应用,旨在增强 BRMS 的适应性、预测能力和整体功效。通过全面的回顾、案例研究和对行业特定影响的分析,本文阐明了与这种集成相关的多方面优势和挑战。探讨了道德考虑、用户体验以及 BRMS 中 AI 和 ML 技术不断发展的前景,为革新决策支持系统的潜力提供了宝贵的见解。这项研究有助于持续讨论 BRMS 的发展,将 AI 和 ML 定位为跨不同行业决策过程创新的催化剂。
引言黑色素瘤与所有其他恶性肿瘤相比,在晚期疾病中形成脑转移(BRM)的倾向最高(1)。免疫检查点抑制剂(ICI)已成为晚期黑色素瘤的中央治疗方法,并且仅在过去5年内进行了II期临床试验,才表明这些药物的颅内功效(2)。结合ipilimumab和nivolumab的最有效的ICI方案的响应率接近58%,但59%的个体发展了3-4级严重的不良事件(3)。对于那些最初没有反应,治疗进展或发展限制治疗的毒性(例如水肿或辐射坏死)的人,迫切需要替代方法。那些活跃的,以前未经治疗的BRM的人具有进一步的治疗局限性,因为许多试验仅允许那些患有小的,异常的转移或以前受辐照病变的试验。对穿透血脑屏障(BBB)并改善ICI活动的替代策略有直接且未满足的需求,而不会加剧毒性。最近的证据表明双重ICI和血管生成靶向的协同作用(4,5)。肿瘤利用增强的VEGF信号传导来逃避免疫系统并通过增加血管生成来促进生长(6)。用高剂量IL-2或ipilimumab治疗的黑色素瘤患者的生存率降低与较高的VEGF水平有关,因此,这表明可溶性VEGF可以用作临床结果的生物标志物,并具有逆转免疫抑制性肿瘤微型微环境(TME)的潜在靶标(TME)(7,8)。VEGF促进了Treg和髓样衍生的抑制细胞(MDSC)膨胀,抑制DC成熟,减轻效果T细胞反应,并改变淋巴细胞的运输到肿瘤中(9-14)。相反,血管生成抑制剂会促进T细胞浸润并减少免疫抑制肿瘤相关的巨噬细胞(TAMS)(15,16)。
AFRISA African Institute for Strategic Animal Resource Services and Development AMIS Assessment Management Information System ART Anti-Retroviral Therapy BoQs Bills of Quantities BRMS Basic Requirements and Minimum Standards BSFL Black Soldier Fly Larvae BTVET Business and Technical Vocational Education Training CAP College of American Pathologists CBOs Community-Based Organisations CBTC Competency Based Training curricula CDC Centre for Disease Control CDOs Community Development Officers CEMRS Comprehensive Electronic Medical Records System CERC Contingency Emergency Response Component CLTS Community-Led Total Sanitation COU Church of Uganda COVID-19 Corona Virus Disease 2019 CPHL Central Public Health Lab CPs Community Polytechnics CSOs Civil Society Organizations CST Certificate in Science and Technology CUUL Consortium for Uganda University Libraries DBS Diploma in Business Studies DCDO District Community Development Officer DDEG Discretionary Development Equalization Grants DEO District Education Officer DES Directorate of Education标准DHI地区卫生检查员DHIC文凭DHIC文凭和机构餐饮DINU开发计划北部乌干达北部DIS DISS地区检查员DLG区域政府DLIS DLIS DLIS DLIS DLIS DLIS DLIS DLIS文凭DPLM DPLM DPLM物流和物流管理文凭
ACALISE African Centre of Excellence in Agro-Ecology and Livelihood Systems ASRH Adolescent Sexual Reproductive Health BoQs Bills of Quantities BRMS Basic Requirements and Minimum Standards BSFL Black Soldier Fly Larvae BTVET Business and Technical Vocational Education Training CBTC Competency Based Training curricula CDC Centre for Disease Control COU Church of Uganda COVID-19 Corona Virus Disease 2019 CPHL Central Public Health Lab CPs Community Polytechnics CUUL Consortium for Uganda University Libraries DBS Diploma in Business Studies DDEG Discretionary Development Equalization Grant DEO District Education Officer DES Directorate of Education Standards DIS District Inspector of Schools DLG District Local Government DLIS Diploma in Library and Information Science DPLM Diploma in Procurement and Logistics Management DRIM Diploma in Records and Information Management DSC District Service Commission DSIM Diploma in Secretarial and Information Management ECCE Early Childhood Care Education ECD Early Childhood Development EGM Early Grade Math EGR Early Grade Reading EMIS Education Management Information System ESA Education Service Agency ESC Education Service Commission ESIA Environmental and Social Impact Assessment ESP Expand Social Protection FCI Faculty of Computing and Informatics FY Financial Year GAVI Global Alliance for Vaccine Initiative GFS Gravity Flow Scheme GOU Government of Uganda HCDP Human Capital Development Project HEIs Higher Education Institutions HESFB Higher Education Students' Financing Board
美国股票周三关闭(19/2):道琼斯指数 +0.16%,标准普尔500 +0.24%,纳斯达克股票 +0.07%。市场上升,标准普尔触动了新的记录,因为投资者权衡了特朗普最新的关税威胁和美联储的会议记录。UST 10Y收益率下降了-0.42%(-0.019bps)至4.533%,而USD指数上涨 +0.13%至107.2。商品市场在周三(19/2)大部分关闭; WTI油 +0.56%至72.25/bbl,布伦特油 +0.34%至76.07/bbl,煤炭 +2.68%至107.40/吨/吨,CPO +3.66%至MYR 4,637,黄金-0.06%,至2,933/Oz。亚洲股票在周三(19/2)混合交易:Hang Seng -0.14%,Nikkei -0.27%和上海 +0.81%。JCI跌至6,794.9(-1.14%),外国投资者的总净销售额为11.12万亿;常规市场中的IDR 9636亿,在谈判市场中IDR 1662亿。常规市场中最大的外国流入量是由TLKM(IDR 1,162亿)记录的,其次是ASII(IDR 665亿)和INDF(INDF(IDR 497亿))。普通市场中最大的外国流出量是由BBCA(IDR 6903亿)记录的,其次是BMRI(IDR 2185亿)和Bren(IDR 2100亿)。最高领先的推动者是TPIA,DCII,BRMS,而顶级落后的移动器是BMRI,BBCA,BBRI。KOSPI今天早上下跌-0.35%,Nikkei(-0.58%)也是如此。我们预计,鉴于全球和区域市场的情感混杂,JCI今天将侧向移动。