摘要:2型糖尿病,以前称为“非胰岛素依赖性糖尿病”或“成人发作糖尿病”,占所有糖尿病的90-95%。这种类型涉及患有相对(而不是绝对)胰岛素缺乏症并患有外周胰岛素抵抗的人。本研究旨在通过评估肿瘤坏死因子α,apelin和visfatin水平来检测巴格达省新诊断的两型糖尿病性梅洛蒂斯患者的血清标记。在当前的研究中,(140)参与者被招募并分组为:患者组(70例新诊断为T2DM的患者,以及(70个显然是健康的对照组)。在当前的研究中,年龄和性别匹配的健康个体。结果表明,通过使用ELISA技术来估计TNF-α,Apelin和visfatin的血清水平。此外,T2DM患者中TNF-α,Apelin和visfatin的平均血清水平为366.08±76.99 pg/ml,96.61±46.61±46.62 pg/ml和9.59±3.62ng/ml,比健康的主题更高,该主题(175.86)(175.86) 15.67±1.74 pg/ml和2.15±0.33ng/ml,具有非常显着的差异(p <0.0001)。因此,可以将TNF-α,粘蛋白和阿位蛋白用于诊断生物标志物,并作为预测离子和预防DM并发症的有用工具。
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Johannes WM Osterrieth, James Rampersad, David Madden, Nakul Rampal, Luka Skoric, Bethany Connolly, Mark D. Allendorf, Vitalie Stavila, Jonathan L. Snider, Rob Ameloot, João Marreiros, Conchi Ania, Diana Azevedo, Enrique Vilarrasa-Garcia, Xinca F, Buan, Buan, Hanze, Hanze, Neil. R. Champness, Sarah L. Griffin, Banglin Chen, Rui-Biao Lin, Benoit Coasne, Seth Cohen, Jessica C. Moreton, Yamil J. Colón, Linjiang Chen, Rob Clowes, François-Xavier Coudert, Yong Cui, Bang Hou, Deanna M. D'Alessandro, Payne Dohen, Doen, Doe, Sun, Christian. Michael Thomas Huxley, Jack D. Evans, Paolo Falcaro, Raffaele Ricco, Omar Farha, Karam B. Idrees, Timur Islamoglu, Pingyun Feng, Huajun Yang, Ross S. Forgan, Dominic Bara, Shuhei Furukawa, Eli Sanchez, Jorge Gascon, Selvedin Telalović, Sukho Khamed, Khammed Murji, Murji Murji, Matthew R. Saum. diq, Patricia Horcajada, Pablo Salcedo-Abraira, Katsumi Kaneko, Radovan Kukobat, Jeff Kenvin, Seda Keskin, Susumu Kitagawa, Ken-ichi Otake, Ryan P. Lively, Stephen JA DeWitt, Phillip Llewellyn, Bettina V. Lotsch, Sebastian T. Ender, Alexander M. Pati M. Pati M. al, Javier García-Martínez, Noemi Linares, Daniel Maspoch, Jose A. Suárez del Pino, Peyman Moghadam, Rama Oktavian, Russel E. Morris, Paul S. Wheatley, Jorge Navarro, Camille Petit, David Danaci, Matthew J. Rosseinsky, Alexandros P., Kat Schunder, Martin Xu, Sergeant, Sergian, Sergeant. s Mouchaham, David S. Sholl, Raghuram Thyagarajan, Daniel Siderius, Randall Q. Snurr, Rebecca B. Goncalves, Shane Telfer, Seok J. Lee, Valeska P. Ting, Jemma L. Rowlandson, Takashi Uemura, Tomoya Iiyuka, Monique A. van der Revere, David Revere, Speed, M.J. and Lamaire, Krista S. Walton, Lukas W. Bingel, Stefan Wuttke, Jacopo Andreo, Omar Yaghi, Bing Zhang, Cafer T. Yavuz, Thien S. Nguyen, Felix Zamora, Carmen Montoro, Hongcai Zhou, Angelo Kirchon, and David Fairen-Jimenez*
Johannes WM Osterrieth, James Rampersad, David Madden, Nakul Rampal, Luka Skoric, Bethany Connolly, Mark D. Allendorf, Vitalie Stavila, Jonathan L. Snider, Rob Ameloot, João Marreiros, Conchi Ania, Diana Azevedo, Enrique Vilarrasa-Garcia, Xinca F, Buan, Buan, Hanze, Hanze, Neil. R. Champness, Sarah L. Griffin, Banglin Chen, Rui-Biao Lin, Benoit Coasne, Seth Cohen, Jessica C. Moreton, Yamil J. Colón, Linjiang Chen, Rob Clowes, François-Xavier Coudert, Yong Cui, Bang Hou, Deanna M. D'Alessandro, Payne Dohen, Doen, Doe, Sun, Christian. Michael Thomas Huxley, Jack D. Evans, Paolo Falcaro, Raffaele Ricco, Omar Farha, Karam B. Idrees, Timur Islamoglu, Pingyun Feng, Huajun Yang, Ross S. Forgan, Dominic Bara, Shuhei Furukawa, Eli Sanchez, Jorge Gascon, Selvedin Telalović, Sukho Khamed, Khammed Murji, Murji Murji, Matthew R. Saum. diq, Patricia Horcajada, Pablo Salcedo-Abraira, Katsumi Kaneko, Radovan Kukobat, Jeff Kenvin, Seda Keskin, Susumu Kitagawa, Ken-ichi Otake, Ryan P. Lively, Stephen JA DeWitt, Phillip Llewellyn, Bettina V. Lotsch, Sebastian T. Ender, Alexander M. Pati M. Pati M. al, Javier García-Martínez, Noemi Linares, Daniel Maspoch, Jose A. Suárez del Pino, Peyman Moghadam, Rama Oktavian, Russel E. Morris, Paul S. Wheatley, Jorge Navarro, Camille Petit, David Danaci, Matthew J. Rosseinsky, Alexandros P., Kat Schunder, Martin Xu, Sergeant, Sergian, Sergeant. s Mouchaham, David S. Sholl, Raghuram Thyagarajan, Daniel Siderius, Randall Q. Snurr, Rebecca B. Goncalves, Shane Telfer, Seok J. Lee, Valeska P. Ting, Jemma L. Rowlandson, Takashi Uemura, Tomoya Iiyuka, Monique A. van der Revere, David Revere, Speed, M.J. and Lamaire, Krista S. Walton, Lukas W. Bingel, Stefan Wuttke, Jacopo Andreo, Omar Yaghi, Bing Zhang, Cafer T. Yavuz, Thien S. Nguyen, Felix Zamora, Carmen Montoro, Hongcai Zhou, Angelo Kirchon, and David Fairen-Jimenez*
Johannes WM Osterrieth, James Rampersad, David Madden, Nakul Rampal, Luka Skoric, Bethany Connolly, Mark D. Allendorf, Vitalie Stavila, Jonathan L. Snider, Rob Ameloot, João Marreiros, Conchi Ania, Diana Azevedo, Enrique Vilarrasa-Garcia, Xinca F, Buan, Buan, Hanze, Hanze, Neil. R. Champness, Sarah L. Griffin, Banglin Chen, Rui-Biao Lin, Benoit Coasne, Seth Cohen, Jessica C. Moreton, Yamil J. Colón, Linjiang Chen, Rob Clowes, François-Xavier Coudert, Yong Cui, Bang Hou, Deanna M. D'Alessandro, Payne Dohen, Doen, Doe, Sun, Christian. Michael Thomas Huxley, Jack D. Evans, Paolo Falcaro, Raffaele Ricco, Omar Farha, Karam B. Idrees, Timur Islamoglu, Pingyun Feng, Huajun Yang, Ross S. Forgan, Dominic Bara, Shuhei Furukawa, Eli Sanchez, Jorge Gascon, Selvedin Telalović, Sukho Khamed, Khammed Murji, Murji Murji, Matthew R. Saum. diq, Patricia Horcajada, Pablo Salcedo-Abraira, Katsumi Kaneko, Radovan Kukobat, Jeff Kenvin, Seda Keskin, Susumu Kitagawa, Ken-ichi Otake, Ryan P. Lively, Stephen JA DeWitt, Phillip Llewellyn, Bettina V. Lotsch, Sebastian T. Ender, Alexander M. Pati M. Pati M. al, Javier García-Martínez, Noemi Linares, Daniel Maspoch, Jose A. Suárez del Pino, Peyman Moghadam, Rama Oktavian, Russel E. Morris, Paul S. Wheatley, Jorge Navarro, Camille Petit, David Danaci, Matthew J. Rosseinsky, Alexandros P., Kat Schunder, Martin Xu, Sergeant, Sergian, Sergeant. s Mouchaham, David S. Sholl, Raghuram Thyagarajan, Daniel Siderius, Randall Q. Snurr, Rebecca B. Goncalves, Shane Telfer, Seok J. Lee, Valeska P. Ting, Jemma L. Rowlandson, Takashi Uemura, Tomoya Iiyuka, Monique A. van der Revere, David Revere, Speed, M.J. and Lamaire, Krista S. Walton, Lukas W. Bingel, Stefan Wuttke, Jacopo Andreo, Omar Yaghi, Bing Zhang, Cafer T. Yavuz, Thien S. Nguyen, Felix Zamora, Carmen Montoro, Hongcai Zhou, Angelo Kirchon, and David Fairen-Jimenez*
Johannes WM Osterrieth, James Rampersad, David Madden, Nakul Rampal, Luka Skoric, Bethany Connolly, Mark D. Allendorf, Vitalie Stavila, Jonathan L. Snider, Rob Ameloot, João Marreiros, Conchi Ania, Diana Azevedo, Enrique Vilarrasa-Garcia, Xinca F, Buan, Buan, Hanze, Hanze, Neil. R. Champness, Sarah L. Griffin, Banglin Chen, Rui-Biao Lin, Benoit Coasne, Seth Cohen, Jessica C. Moreton, Yamil J. Colón, Linjiang Chen, Rob Clowes, François-Xavier Coudert, Yong Cui, Bang Hou, Deanna M. D'Alessandro, Payne Dohen, Doen, Doe, Sun, Christian. Michael Thomas Huxley, Jack D. Evans, Paolo Falcaro, Raffaele Ricco, Omar Farha, Karam B. Idrees, Timur Islamoglu, Pingyun Feng, Huajun Yang, Ross S. Forgan, Dominic Bara, Shuhei Furukawa, Eli Sanchez, Jorge Gascon, Selvedin Telalović, Sukho Khamed, Khammed Murji, Murji Murji, Matthew R. Saum. diq, Patricia Horcajada, Pablo Salcedo-Abraira, Katsumi Kaneko, Radovan Kukobat, Jeff Kenvin, Seda Keskin, Susumu Kitagawa, Ken-ichi Otake, Ryan P. Lively, Stephen JA DeWitt, Phillip Llewellyn, Bettina V. Lotsch, Sebastian T. Ender, Alexander M. Pati M. Pati M. al, Javier García-Martínez, Noemi Linares, Daniel Maspoch, Jose A. Suárez del Pino, Peyman Moghadam, Rama Oktavian, Russel E. Morris, Paul S. Wheatley, Jorge Navarro, Camille Petit, David Danaci, Matthew J. Rosseinsky, Alexandros P., Kat Schunder, Martin Xu, Sergeant, Sergian, Sergeant. s Mouchaham, David S. Sholl, Raghuram Thyagarajan, Daniel Siderius, Randall Q. Snurr, Rebecca B. Goncalves, Shane Telfer, Seok J. Lee, Valeska P. Ting, Jemma L. Rowlandson, Takashi Uemura, Tomoya Iiyuka, Monique A. van der Revere, David Revere, Speed, M.J. and Lamaire, Krista S. Walton, Lukas W. Bingel, Stefan Wuttke, Jacopo Andreo, Omar Yaghi, Bing Zhang, Cafer T. Yavuz, Thien S. Nguyen, Felix Zamora, Carmen Montoro, Hongcai Zhou, Angelo Kirchon, and David Fairen-Jimenez*
Johannes W. M. Osterrieth,James Ramper,David Madden,Nakul Rampal,Luke Skoric,Bethany Connolly,Mark。 Santos,Xian-He Sun,Hana Bunzen,Sateh C. Moreton,Jessica C. Moreton。 M. D'Alessandro,Patrick W. Dohenn,MirceaDincă,Chenyue Sun,Christian Doonan,Michael Thomas Huxley,Jack D. Evans,Paolo Falcaro。 Shuhei Furukawa, Eli Sanchez, Jorge Gascon, Selvedin Telalović, Sujit K. Ghosh, Soumya Mukherjee, Matthew R. Hill, Muhammed Munir Sadiq, Patricia Horcajada, Pablo Salcedo-Abraira, Katsumi Kaneko, Radovan Kukobat, Jeff Kenvin, Seda Keskin, Susumu北川。Johannes W. M. Osterrieth,James Ramper,David Madden,Nakul Rampal,Luke Skoric,Bethany Connolly,Mark。 Santos,Xian-He Sun,Hana Bunzen,Sateh C. Moreton,Jessica C. Moreton。 M. D'Alessandro,Patrick W. Dohenn,MirceaDincă,Chenyue Sun,Christian Doonan,Michael Thomas Huxley,Jack D. Evans,Paolo Falcaro。 Shuhei Furukawa, Eli Sanchez, Jorge Gascon, Selvedin Telalović, Sujit K. Ghosh, Soumya Mukherjee, Matthew R. Hill, Muhammed Munir Sadiq, Patricia Horcajada, Pablo Salcedo-Abraira, Katsumi Kaneko, Radovan Kukobat, Jeff Kenvin, Seda Keskin, Susumu北川。A. Dewitt,免费V. Lotsch。拉玛·奥克塔维安(Rama Octavian),俄罗斯莫里斯(Morris),保罗·圣惠特利(Paul St. Wheatley),纳瓦尔(Navarre Cyderius,Randall Q. Snurr,Rebecca B. Concalves,Shane Telfer,Seok J. Lee,Valska P. Ting,Van Speybroeck,Sven M. Rogge,Krista,Christ。 St. Luke W. Bingel,Stefan Wuttke,Andreo Jacopo,Omar Yaghi。
标题:简化和扩大使用机械化学作者合成的硼咪二唑酯框架(BIF)范围TomislavFriščićA,B * A McGill University的化学系,801 Sherbrooke St. W. H3A 0B8加拿大蒙特利尔。e-邮件:tomislav.friscic@mcgill.ca b frqnt Quebec高级材料中心(QCAM/CQMF),加拿大蒙特利尔,加拿大C CADADIFF大学,加拿大大学,公园大楼,加迪夫CF10 3AT公园广场,英国d,英国d,d pasciff cf10 3at,d pastef,d cf10 d。e Concordia大学生物化学与化学系,7141 Sherbrooke St. W. H4B 1R6加拿大蒙特利尔。 f国际纳米技术研究所,化学系西北大学,2145 Sheridan Road,60208 Sheridan Road,60208 Evanston,伊利诺伊州,伊利诺伊州,伊利诺伊州伊利诺伊州,主要文本机械化学1-7,已成为一种多功能方法,用于合成和高级材料的合成和材料,包括Nananoparticle Systems 8-10和金属eRebressing(包括金属型号)(包括金属型号)(Mofs-Er-Organigics)(Mofs-Erganigy),使用常规的基于解决方案的技术获得。 16–18的机械化学技术,例如球铣削,双螺钉挤出19和声学混合20,21,简化和先进了多种MOF范围的合成,允许使用简单的起始材料,例如金属氧化物,氢氧化物或碳酸盐或碳酸盐,氢氧化物或碳酸盐,在房间温度和较高的表面上,较高的表面上的较高的表面,均等的,均质的稳定性,均可稳定地及其稳定,并稳定地,稳定性,稳定性,稳定性,并稳定地及其稳定性,并在稳定的稳定性,并且稳定的范围是稳定的。同行。e Concordia大学生物化学与化学系,7141 Sherbrooke St. W. H4B 1R6加拿大蒙特利尔。f国际纳米技术研究所,化学系西北大学,2145 Sheridan Road,60208 Sheridan Road,60208 Evanston,伊利诺伊州,伊利诺伊州,伊利诺伊州伊利诺伊州,主要文本机械化学1-7,已成为一种多功能方法,用于合成和高级材料的合成和材料,包括Nananoparticle Systems 8-10和金属eRebressing(包括金属型号)(包括金属型号)(Mofs-Er-Organigics)(Mofs-Erganigy),使用常规的基于解决方案的技术获得。16–18的机械化学技术,例如球铣削,双螺钉挤出19和声学混合20,21,简化和先进了多种MOF范围的合成,允许使用简单的起始材料,例如金属氧化物,氢氧化物或碳酸盐或碳酸盐,氢氧化物或碳酸盐,在房间温度和较高的表面上,较高的表面上的较高的表面,均等的,均质的稳定性,均可稳定地及其稳定,并稳定地,稳定性,稳定性,稳定性,并稳定地及其稳定性,并在稳定的稳定性,并且稳定的范围是稳定的。同行。24,25机械化学在MOF合成和发现中的优势使我们解决了合成硼咪唑酸盐框架(BIF)的可能性,26一种是一种有趣但不足以开发的微孔材料,类似于Zeolitic imidazaly的框架(Zifs),27-29 – 27-29 – 29 – 29 – 29 – 29 – 29 – 29-硼(III)和单价Li +或Cu +阳离子作为节点。尽管BIFS提供了一个有吸引力的机会来访问分子量较低的微孔MOF,尤其是在基于Li+和B(III)中心的“超轻”系统的情况下,这种材料家族在很大程度上尚未探索 - 可能是由于需要在n -butylithium中使用溶液中的溶液环境,因此需要进行严格的综合条件。29现在,我们展示如何切换到机械化学环境使锂和铜(i)基于铜(i)的BIF迅速制备(即,一个小时或更短的时间),没有升高的温度或散装溶剂,以及易于获得的固体反应物,例如氢氧化物和氧化物。虽然机械化学准备的BIF表现出明显高的表面积面积,而机械化学则可以将这种类别的材料扩展到以前未报告的Ag +节点。与基于li +或Cu +的bifs同源性引入,但包括Ag +离子,可以对其稳定性进行定期密度功能功能理论(DFT)评估。这表明,随着四面体节点的稳定性(SODALITE拓扑结构(SOD)开放BIF相对于封闭式包装的Diaondoid(DIA)拓扑多形状,改善了较重的元素。