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Post-transplant Malignancies: Current Perspective on Risk Factors, Prevention, and Management
Post-transplant malignancies arise from a complex interplay of factors, with immunosuppression playing a pivotal role. Chronic immunosuppressive treatment compromises the recipient's immune system, rendering it less efficient at recog- nizing and eliminating malignant cells. Additionally, viral infections, especially Epstein–Barr virus and Human papilloma- virus, are major contributors to malignancy development. Lifestyle modifications, including smoking cessation and sun protection, are recommended for reducing certain cancer risks. Regular screening for malignancies may provide the early diagnosis as in the general population. After the diagnosis of cancer, tailoring immunosuppressive regimens to maintain graft function is crucial. Treatment options, such as chemotherapies, targeted therapies, and immunotherapies, should be selected with consideration of the patient's overall health and the potential impact on the transplanted organ. A multidis- ciplinary approach is required in order to provide optimal treatment to our kidney transplant recipients. With this review article, we aim to discuss pathophysiological mechanisms, review guidelines, and provide information on the incidence and management options for various cancers. Keywords: Immune checkpoint inhibitors, malignancy, prevention, kidney transplantation, screening
由Ross Gyre的扩张
角度和极化选择性自发发射在染料掺杂的金属/绝缘体/金属纳米腔中Vincenzo Caligiuri*，Giulia Biffi，Milan Palei，Beatriz Martin-Garcia，Renuka devi Pothuraju，YannBretonnièredecionalverional verional ver v. v. v. v. v. v. v. V. V. V. V. V. Caligiuri，G。Biffi，M。Palei博士，B。Martin-Garcia博士，P.R。doi，意大利理工学院R. Krahne博士，通过Morego 30，16163 Italy Genoa，意大利电子邮件：roman.krahne@iit.it; vincenzo.caligiuri@iit.it V. Caligiuri物理系，卡拉布里亚大学，87036年，意大利G. Biffi Rende，R。D。Pothuraju，R。D。Pothuraju，化学和工业化学系，Genoa，Genoa，viaecaneso，Dodecaneso，31146，ITALOA，ITALY ECOL Y. BRETONIN，BRITENON，BRETENON。 Superieure de Lyon, CNRS UMR 5182, University Claude Bernard Lyon 1, Laboratoire de Chimie, F69342, Lyon, France Keywords: Epsilon-Near-Zero, Polarized Spontaneous Emission, Push-Pull Chromanophores, Metal-insulator-Metal Cavities Directing and Polarizing the Emission of a Fluorophore is of FundaMental Importance in the
收割机割台高度调节技术
Keywords: BP neural network, fuzzy control, cutting platform height, multisensor ABSTRACT In this paper, BP neural network is used to collect header height, AMEsim is used to simulate and analyze header height adjustment hydraulic system, and fuzzy PID control is used to adjust header lifting hydraulic cylinder to stabilize header height. The experimental results of harvesting different crops show that under the header height automatic control system, the error between the actual height of crop harvesting and the set height is within 15 mm, and the harvesting effect is good, which can meet the automatic regulation requirements of the header height of the multi crop combine harvester. 摘要 为了提高调节的精度，采用 BP 神经网络多传感器融合处理技术采集割台实时高度，通过 AMEsim 软件对割台 高度调节液压系统进行仿真分析，最后采用模糊 PID 控制比例电磁阀调节割台升降液压缸从而稳定割台高度。 通过收获油菜、谷子和水稻的试验结果证明：在割台高度自动控制系统下，作物收获的实际高度与设定高度误
混合充电拓扑的设计和开发
电气工程系阿姆鲁特瓦希尼工程学院，印度桑加纳摘要：拟议的混合充电拓扑旨在通过将智能控制机制与包括电源，solar和储物电池等多个能源集成的智能控制机制来解决现有多功能源（MPS）系统中的关键效率低下。微控制器单元（MCU）构成了系统的核心，根据可用性和需求，协调能源之间的无缝过渡。系统通过动态调整充电参数以匹配电池电压，从而优化太阳能利用率，从而最大程度地提高光伏面板的效率。此外，它结合了多个充电水平，以确保电池健康和寿命最佳。此外，该系统具有配备盈余太阳能为小型直流负载供电的输出功率系统，从而增强了整体能源利用率。Through rigorous testing in diverse environmental conditions, the proposed hybrid charging topology demonstrates reliability and efficiency, offering promising avenues for sustainable energy utilization and advancing power electronics technology Keywords: Hybrid charging, Renewable energy, Intelligent control, Energy optimization, Sustainable technology
BS计算机科学
Course Content: Introduction to problem solving, Programing techniques, Problem solving techniques, Introduction to flowchart, Introduction to algorithms, Introduction to programming, Programing languages, Role of interpreter, compiler, assembler, Basic data types, keywords, Identifiers, Variables and constants, structure of a program, Operator and its types (assignment, increment/ decrement, arithmetic, relational, pointer and logical operators),有条件语句的输入/输出语句，条件语句和执行流，重复语句和执行流，用于重复语句，功能，阵列，指针/引用，字符串处理和字符串操作，结构，静态和动态内存分配，文件I/O操作。教学方法：讲座，书面作业，实践实验室，学期项目，演讲课程评估：会议考试，家庭作业，测验，项目，演示文稿，最终考试参考材料：1。从第4版，托尼·加迪斯（Tony Gaddis）开始。2。从编程逻辑和戴金开始，第4版，托尼·加迪斯（Tony Gaddis），3。C编程语言，第2版，Brian W. Kernighan，Dennis M. Ritchie 4。Robert Lafore 5。使用Python的计算和编程简介：应用于理解
内皮到间充质转变：在心血管健康和疾病的轴上
抽象的内皮细胞（ECS）将血管的腔表面列出，并通过充当屏障，感知循环因子和内在/外在信号，在血管（PATHO） - 物理学中起主要作用。EC具有经历内皮到间质转变（ENDMT）的能力，这是一个复杂的分化过程，在胚胎发育期间和成年期都具有关键作用。EndMT可以导致EC激活和与适应性组织反应有关的人类疾病中的功能失调的改变。在EndMT期间，EC逐渐发生变化，导致间充质标记的表达，同时抑制EC谱系特异性性状。这种典型和功能开关在很大程度上存在于连续体中，其特征是过渡阶段。在本报告中，我们讨论了过程可塑性和潜在的可逆性，并假设不同的EndMT衍生的细胞种群可能在疾病进展或分辨率中起不同的作用。此外，我们回顾了EndMT领域的进步，当前的技术挑战以及心血管生物学背景下的治疗选择和机会。- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Keywords Endothelial-to-mesenchymal transition (EndMT) • Development • Human disease • Endothelial cell biology • Cellular plasticity and heterogeneity • Therapeutic options
运动报告中的具体
keywords: scat6 - CRT6 - Sub -communational impacts - Neurodegenerative diseases - Traumatic chronic encephalopathy - Amyotrophic lateral sclerosis Keys Words: Scat6 - CRT6 - Subconcussive Impacts - Neurodegenerative Diseases - Chronic Traumatic Encepthy - Amyotrophic - Amyotrophic Lateral Sclerosis摘要混合物（CC）占与运动有关的所有创伤的5％至9％，但根据运动类型而有很大的可变性。为了开发业余和休闲运动的实践而实施的政策，这种普遍性数据很可能在很大程度上被低估了。存在许多流行病学论据认为CC会引起神经退行性疾病，慢性创伤性脑病，肌萎缩性侧向硬化症或阿尔茨海默氏病。对于亚交流性颅骨影响，在训练或竞争中的彩排是肌萎缩性侧面硬化症（SLA）或阿尔茨海默氏病死亡的原因，而不是一般人群中的重要性。这是预防策略的实施对于降低这些神经退行性病理发展的风险至关重要的原因。这种策略必须基于保护设备的改进（头盔，某些运动中的燃烧内保护措施），运动员的身体和技术准备更好以及适应运动法规。
体育锻炼对神经系统的影响 作者：PETRONELA PARASCHIV “Gheorghe Asachi” 雅西理工大学，体育与运动科学系
THE INFLUENCES OF PHYSICAL EXERCISES ON THE NERVOUS SYSTEM BY PETRONELA PARASCHIV “Gheorghe Asachi” Technical University of Iaşi, Department for Teacher Training - Physical Education Sport Department Received: November 19, 2024 Accepted for publication: December 12, 2024 Abstract. Exercise is fundamental to a healthy life, positively influencing not only the body but also the mind. In addition to the obvious benefits for physical health, sporting activities have a significant impact on the brain, contributing to the development and maintenance of neuronal functions. The relationship between physical exercise and the nervous system is bidirectional: on the one hand, movement stimulates neurogenesis and brain plasticity, and on the other hand, neural adaptations optimize physical performance. In an increasingly sedentary world, knowledge of these benefits is becoming essential to prevent both physical and mental health problems. Keywords: engineering, students, neuronal system, health. 1. Introduction Physical exercises are fundamental to a healthy life, positively influencing not only the body but also the mind. Beyond the obvious benefits to Corresponding author; e-mail : petronela.paraschiv@academic.tuiasi.ro © 2024 Petronela Paraschiv This is an open access article licensed under the Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
中风康复中无创脑刺激的叙述性回顾
中风是一种具有高发病率和残疾率的疾病，导致神经网络和Corti Coilti Coid-Subbordical兴奋性以及各种功能障碍的变化。本研究的目的是讨论研究和局限性的当前状态以及潜在的脑刺激（NIB）在中风后患者中的应用。本文献评论的重点是临床研究和评论。Literature retrieval was conducted in PubMed, Cochrane, Scopus, and CNKI, using the following keywords: Repeated tran scranial magnetic stimulation, Transcranial direct current stimulation, Transcranial alternating current stimu lation, Transcranial alternating current stimulation, Transcranial focused ultrasound, Noninvasive vagus nerve stimulation, Stroke, and Rehabilitation.我们从1985年至2022年选择了200个相关出版物。概述了有关在势后患者中使用Nibs的最新研究，包括其机制，治疗性的体系，效果和安全性。发现笔尖对运动，感觉，认知，语音，吞咽和中风后的运动功能障碍具有积极的治疗作用，但仍缺乏标准化的刺激程序。文献表明，RTMS和TDC对中风后患者更有益，而TFUS和TVNS目前的研究后进行后恢复后康复更少，但也是潜在的干预措施。
在德国实现100％可再生能源系统
德国发布了新的气候目标，以便到2045年达到气候中立。本文展示了到2050年的德国电力电网成本最佳能源供应系统的途径。对区域性的特殊考虑，该系统基于年度近视优化，并采用了所需的能源系统转换措施和相关的系统成本。结果指出，能源存储系统（ESS）是可再生能源集成的基础，以便进行可行的能量过渡。此外，对存储技术的投资增加了太阳能和风能技术的使用。太阳能投资高度伴随着短期电池存储的安装。长期存储技术（例如H2）伴随着风力技术的高安装。结果指出，如果氢投资的成本继续大幅降低，预计氢投资将覆盖短期电池。此外，在能量系统中ESS的强烈存在，预计将完全排除生物质能量。With the current emission reduction strategy and without a strong presence of large scale ESS into the system, it is unlikely that the Paris agreement 2° C target by 2050 will be achieved, let alone the 1.5° C Keywords: Energy Market, Energy Planning, 1.5-Degree- target, Energy Storage Systems, Grid Integration, Energy System Optimization