Nesta

评估人类未成熟牙髓干细胞（Nestacell®）通过静脉内给药的生物分布：一种非临床研究

我们使用专门的DP外植物方法成功地掌握了DPSC的分离，从而通过连续的DP机械转移来促进细胞增殖，从而产生了人类未成熟的牙髓基质/干细胞（HIDPSC）[8,11]。我们的发现支持了这一独特的成年MSC子集的潜力，该子集是从六到十二岁的儿童的落叶牙中分离出来的，作为治疗神经退行性疾病的有希望的候选者[2,8,10,12-15]。This promise stems from their ectomesenchymal origin (neural crest), which inherently triggers hIDPSCs to produce and release various neural factors, including nestin (a marker of neural stem/progenitor cells) [16,17] and high level of brain- derived neurotrophic factor (BDNF, which is depleted in patients with Huntington's disease – HD) [3,11,18].尽管观察到来自各种组织和HIDPSC的MSC之间的差异，但它们明确地符合国际细胞治疗学会定义多能MSC的所有标准[19,20]。