组织居民巨噬细胞(TRM)是适应局部微环境的专业髓样细胞,并执行核心巨噬细胞功能,例如吞噬和免疫监测,以及组织特异性的作用(Troutman等人,2021年)。The identity of TRMs is established by a combination of their ontogeny (or lineage) and the surrounding tissue environment that provides distinct signaling cues to educate TRMs toward more specialized functions, such as synaptic pruning by microglia ( Butovsky and Weiner, 2018 ; Prinz et al., 2019 ; Troutman et al., 2021 ; Paolicelli et al., 2022 ).在机械上,信号诱导的转录因子活性导致组织特异性的染色质重塑和增强子激活叠加在核心巨噬细胞基因表达程序上(Lavin等,2014; Troutman等,2021)。然而,基于人类细胞的实验系统,用于探测TRM的个体亚型,例如脑巨噬细胞的亚型,以及描绘TRM专业化的分子机制,在很大程度上缺乏。在这种意见中,我们提出了一个诱导多能干细胞(IPSC)衍生的神经免疫器官的平台,以建立基于人类细胞的脑TRM模型的多样性,并研究其在组织稳态和疾病中的作用。
•带有条形图和双重阅读显示显示•自动背光(可以禁用)•50V,100V,100V,250V,500V,1000V,1000V-最高200G-极化指数(PL) - 介电吸收比(DAR) - 定时测试(IJP至40分钟)•连续bondusigrandmame(连续)(连续)(连续)(0.0), - Automatic bi-directional test (show the higher one) • 600V DC & AC (TRMS) measurement - Low-pass Filter (LPF) • 0.1nF to 10gF Capacitance measurement • COMPARE (Pass/Fail) Function - Available for Insulation Test and Earthbond Resistance - 2 color LED Indicator (Green / Red) & Sounds (Continuous Beep / Beep twice) • Store / Recall Function - 1500 records for each function • Bluetooth与Powerprope®链接应用程序的连接