方法,我们使用预防非洲肝纤维化和癌症的数据在冈比亚开发了一种自然历史模型,该模型是冈比亚的20岁个体的HBV感染队列。The algorithms included in the model were a conventional strategy using the European Association for the Study of the Liver (EASL) 2017 criteria, a simplified algorithm using hepatitis B e antigen and alanine aminotransferase (the Treatment Eligibility in Africa for the Hepatitis B Virus [TREAT-B] score), a Treat All approach for all HBV-infected individuals, and the WHO 2015 criteria.衡量有效性的结果是残疾调整的寿命(DALY)和挽救的寿命(YLS),这些寿命(YLS)被用来计算WHO 2015标准作为基础案例场景的增量成本效益比(ICER)。从修改后的社会角度评估了费用。还进行了预算影响分析。我们通过一系列灵敏度分析(包括概率灵敏度分析)测试了结果的鲁棒性。