yiqi yangyin jiedu配方的临床功效与tislelizumab结合在治疗驱动器 - 元素阴性晚期NSCLC及其对外围免疫指标
摘要 摘要目的目的:评价小剂量阿帕替尼联合替吉奥联合健脾补肾解毒方治疗二线及以上治疗失败的转移性结直肠癌(mCRC)患者的疗效和安全性,为二线及以上综合治疗方案治疗失败的转移性结直肠癌(mCRC)患者提供更多的治疗选择。方法 方法:2019年4月至2020年9月,从一项单臂开放标签临床研究中选取了13名患者。患者分别接受低剂量阿帕替尼(250 mg,每天一次)和S-1(20 mg,每天一次)治疗。2020年9月至2020年9月,从一项单臂开放标签临床研究中选取了13名患者。患者分别接受低剂量阿帕替尼(250 mg,每天一次)和S-1(20 mg,每天一次)治疗。
NOTES: MOE, Ministry of Education; NSFC, National Science Foundation of China; SAFEA, State Administration of Foreign Expert Affairs; CLGCTW, Central Leading Group for the Coordination of Talent Work. (a) The 100 Talents Plan initially included part-time participants, but the CAS changed this policy around 2004. Too many individuals accepted the award, but rarely appeared at the CAS (Hao Xin, 2006). (b) “Two-decade Development of the Hundred Talent Program” (Chinese Academy of Sciences, n.d.) reported that 90 percent of the 2,145 total awardees were from abroad, yielding 1,930 program participants. (c) Liu Bin, Qiao Lili, and Zhang Yi, “An Analysis of the Funding Status and Achievement Impact of National Science Fund for Distinguished Young Scholars in the Life Sciences” (in Chinese), Science Funds in China , No. 2 (2016): 122−131. (d) The Spring Light Program brought more than 300 delegations to China by the end of 2009. These consisted of 15,000 overseas mainlanders who established more than 1,000 projects 赵峰 , 苗丹国 , 魏祖 钰 , 程希 (Zhao Feng, Miao Danguo, Wei Zuyu, Cheng Xi), eds., 留学大事概 览 , 1949–2009 (An Overview of Overseas Study, 1949–2009). 北京: 现代出版社 , 2010, 86. From 2006 to 2018, the Chunhui Award ( 春 晖杯 ) had shortlisted 2,528 projects, of which 448 (17 percent) relocated to China. By 2023, 3,424 “excellent” projects had been selected. See Andrew Spear, “Serve the Motherland while working overseas,” in William C. Hannas and Didi Kirsten Tatlow, eds., China's Quest for Foreign Technology: Beyond Espionage (London: Routledge, 2021 ) 30-31. (e) SAFEA was closed in 2018 and reconstituted under the MOST. See 2017 Budget of the Former State Administration of Foreign Experts Affairs , CSET, Washington, DC, https://cset.georgetown.edu/publication/2017-budget-of-the-former-state-administration-of-foreign-experts- affairs/. (f) The names of the 111 Program project bases are posted at https://opportunities- insight.britishcouncil.org/news/market-news/introduction-china%E2%80%99s-%E2%80%9C111- project%E2%80%9D-0 (British Council, 2017). (g) There were 4,128 TTP awardees at the end of 2014, with an additional 1,028 participants joining TTP in 2015. China's TTP has attracted 5,206 high-end oversea talents' [Zhongguo “qianrenjihua” yinjin 5206 ming haiwai gaocengci rencai], accessed March 10, 2020, http://www.gqb.gov.cn/news/2016/0107/37723.shtml. The Chinese media estimated 8,000 total TTP awardees in 2018. “Shengdu jiedu: guojia ‘qianrenjihua' rencai xiangmu shenbao” [‘In-depth interpretation: 2018 national TTP application'], accessed October 2, 2019,
在2019年12月,在湖北省武汉市发现了许多病毒性肺炎病例。到2020年2月,全国范围内有20,000多例2019年冠状病毒疾病(Covid-19),有425例患者死亡。在这次暴发中,西方医学在不识别病原体的情况下进行有针对性的治疗很难,但是传统中药(TCM)可以通过综合征分化和治疗迅速确定原因(Zeng等,2020)。covid-19属于TCM中“流行病”类别,其病理变化首先出现在间质肺中(Yang and Fan,2021)。主要症状是发烧,干性咳嗽和疲劳。在严重的情况下,可能会发生肺合并(Miao等,2020; Xiong,2020; Zhan等,2020)。鉴于这些症状,应用了许多处方,例如金胡乌拉甘格颗粒,Shufeng Jiedu胶囊,Jingfang颗粒和Jinbei口服液体(JB。l),并在诊所显示出明显的治愈作用。在其中,JB。L在2020年2月在山东省(第二版)的新型冠状病毒肺炎的中药诊断和治疗计划中列出,我们随后的临床数据分析表明,JB的效果。L优于单一化学疗法组(Li等,2021)。JB。它具有补充气和滋养阴,驱除血液停滞和去除痰液的作用。因此,在本实验中,JB的化学组成。L is composed of Astragali radix , Codonopsis radix , Angelica sinensis , Glehniae radix , Scutellariae radix , Fritillariae cirrhosae bulbus , Chuanxiong rhizoma , Salvia miltiorrhiza radix , Pinelliae rhizoma praeparatum cumalumine , Lonicerae japonicae fl os , Forsythiae Fructus和Glycyrrhizae radix。尽管TCM处方具有一定的理论和临床应用基础,但复合TCM处方的材料基础很复杂,而动作机制是多种多样的,这给TCM的有效性带来了基本材料研究。近年来,连字符技术是对复杂矩阵中未知化合物的快速定性分析的强大工具,尤其是超出性液态色谱,以及四极杆的时间串联串联质量光谱法(UPLC-Q-Q-TOF-MS),这是有益于其高分辨率和敏感性的。这些方法已被证明是对TCM制剂快速分析的有效和高度敏感的工具(Gao等,2014; Zhang等,2017a; li等,2018; Wang等,2018; Sun等,2021)。此外,UPLC与三极四极质量光谱法(UPLC-QQQ-MS/MS)可以很好地应用于通过多个反应监测(MRM)模式对TCM多个化学成分的定量分析,这在TCM的现代化中具有很大的意义(Wu et and an e et al。 )。研究TCM效率的材料基础是解决TCM有效作用原理的先决条件,而确定TCM的有效组成部分是主要任务。l通过UPLC-Q-TOF-MS/MS定性确定,并且主要功能组件通过UPLC-MS/MS定量分析。这是关于JB化学成分的系统分析的第一个报告。l,为质量控制和对其药效学的深入研究提供了基础。