Results: Among 5 RCTs included with 456 ALD patients who received probiotics, the therapeutic pooled effects in the experimental group were the followings: ALT (MD = − 7.16.95% CI: 10.71~-3.60; p < 0.0001) 、 AST (MD = − 25.11.95% CI: 30.57~- 19.47; p < 0.00001) 、 GGT (MD = - 6.72.95%CI:11.91〜-1.53; P = 0.01)、IL- 6(SMD = - 0.82.95%CI:1.10〜-0.54; P <0.00001),它们在安慰剂或标准治疗组中的显着好处,分别是安慰剂或标准治疗组中的0.6%,同时差异0.09,smd = smd = smd = smd = smd = s, - 0.16; p = 0.59),TNF-α(SMD = - 0.53.95%CI:1.57 - 0.50; p = 0.31)在两组中并不重要。在实验组中,肠道MTT治疗后,肠双杆菌的数量显着增加(MD = 0.79.95%CI:0.00 - 1.58; P = 0.05)。但是,两组的大肠杆菌数量均无显着变化(SMD = - 0.29.95%CI:0.92 - 0.34; p = 0.36)。
