抽象天然产品已用于治疗多种疾病已有数千年的历史,并用作改善生计的药物铅化合物的来源。本文介绍了从八种植物物种土著到坦桑尼亚分离的选择天然产物的生物医学潜力的综述。审查涵盖了2010年至2023年之间发表的研究工作,并确定了33种具有来自坦桑尼亚植物的药理特性的天然产品。这些生物活性天然产物与其他类似的化合物讨论了从相同或不同植物物种其他地方隔离的其他类似化合物,以进一步了解现代医学中潜在应用的信息,该信息基于从在线搜索的不同数据库中获得的信息,包括化学摘要,Google Scholar,Medline,PubMed,PubMed和Science直接使用不同的关键单词或短语。审查包括来自Erythrina Schliebenii(Fabaceae)的抗结核,抗癌和神经保护性类黄酮,抗结尾和抗氧化代谢物来自三种红树林物种Heritiera Littoralis(sterculiaceae)(sterculiaceae),木质酸脂肪酸脂肪酸(Meliaceaeae)(Meliaceaeae)(Meliaceaeaeeaeaeaeaeaeaeaeae)(Meliaceae)(Meliaceaeae)(son)(son)。该综述还涵盖了来自Morinda Asteroscepa(Rubiaceae)的抗血状s虫类固醇和虹膜,,来自两个OCHNA物种(OCHNACEAE)的抗菌双脱藻类动物,抗病毒和抗血管疾病的抗血统二甲苯二苯甲酸酯,来自Croton kloton klorbiaceaeeee klorbiaceaeeee anthorbiaceaeeee and euphorbiaceee和其他其他构成。这些植物中的大多数在坦桑尼亚罕见,流行或接近流行。必须阐明铅化合物的作用模式,并针对有针对性的疾病治疗进行临床研究。Of these natural products, the catechinoid 13 (IC 50 4.5 µg/mL) was four times more active than the positive control towards radical scavenging, the biflavonoid 31 (MIC 2.2 μM) was more potent in antibacterial assay than the standard drug, whereas diterpenoids 34-36 demonstrated strong anti-proliferative effect against the malaria parasite Plasmodium falciparum (80-100%,50μm),使他们有望进行药物开发。审查论证了与实现生物医学剂的全部潜力相关的挑战,例如可伸缩性,毒性,溶解度和生物利用度,从而呼吁协同的研究努力解决它们,以解决他们在自然产物中占有依靠药物开发的潜力。关键词:坦桑尼亚植物群;抗原;抗癌;抗氧化剂;抗病毒物质;抗菌;神经保护;抗炎简介
。CC-BY-NC-ND 4.0 国际许可,根据 未经同行评审认证)是作者/资助者,他已授予 bioRxiv 永久展示预印本的许可。它是 由 此预印本的版权持有者(此版本于 2020 年 5 月 27 日发布。 ; https://doi.org/10.1101/2020.05.26.117390 doi: bioRxiv preprint
nephritis, interstitial (acute intestitial nephritits (AIN) is the cause of acute kidney disease (Acute Kidney Injury) that is not very common. It was found that the drug in the NSAIDS group is the cause of the InSerstitial Peritis. Selective Cox-2 Inhibitors NSAIDs also reported that it can also cause nephritis in this article. Reported a 63 -year -old male patient who has been连续药物治疗的脊椎病在大约1周后,医生分析了急性肾脏衰竭的原因。没有必要进行透析nephritis, interstitial (acute intestitial nephritits (AIN) is the cause of acute kidney disease (Acute Kidney Injury) that is not very common. It was found that the drug in the NSAIDS group is the cause of the InSerstitial Peritis. Selective Cox-2 Inhibitors NSAIDs also reported that it can also cause nephritis in this article. Reported a 63 -year -old male patient who has been连续药物治疗的脊椎病在大约1周后,医生分析了急性肾脏衰竭的原因。没有必要进行透析